scholarly journals A COMPARATIVE EVALUATION OF SINGLE DOSE TRANSDERMAL PATCH OF DICLOFENAC VERSUS KETOPROFEN FOR POST OPERATIVE ANALGESIA IN ABDOMINAL HYSRETECTOMY.

2020 ◽  
pp. 1-2
Author(s):  
Gaurav Panchal ◽  
Bhavna Sojitra ◽  
Divyang Shah
Keyword(s):  
Social Sciences ◽  
Single Dose ◽  
Comparative Evaluation ◽  
Diclofenac Sodium ◽  
Abdominal Hysterectomy ◽  
Transdermal Patch ◽  
Efficacy And Safety ◽  
Rescue Analgesia ◽  
Number Of Patients ◽  
To Receive

Introduction: Transdermal patch is very simple and painless method for providing postoperative analgesia. The aim of the study was to compare the efficacy and safety of transdermal patch of ketoprofen in comparion to diclofenac for post operative analgesia. It is randomized observational study. Method: Thirty six patients of 18 to 60 years were randomly allocated to receive either ketoprofen or diclofenac transdermal patch at the end of surgery under spinal anaethesia. Stastical analyasis used, data were analysed using statistical package for social sciences version 15.0 and open EPI software version 2.3. The primary end point is VAS score and total requirement of rescue analgesic first 24 hours of surgery. The secondary end points are time to rescue analgesic and adverse effects like nausea and vomiting. Conclusion: Single dose transdermal patch of Ketoprofen provided better post operative analgesia as compared to diclofenac sodium patch in abdominal hysterectomy (infraumblical surgeries) and less number of patients required rescue analgesia in ketoprofen group.

scholarly journals Comparative efficacy and safety of intra-articular analgesics after knee arthroscopy: a Bayesian network meta-analysis protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035346
Author(s):  
Yuchen He ◽  
Hongyi He ◽  
Dong-Xing Xie ◽  
Xiaoxiao Li ◽  
Yilun Wang
Keyword(s):  
Single Dose ◽  
Pain Relief ◽  
Bayesian Network ◽  
Knee Arthroscopy ◽  
Meta Analysis ◽  
Arthroscopic Surgery ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Comparative Efficacy ◽  
Number Of Patients

IntroductionMost of the patients who received arthroscopic knee surgery will suffer moderate to severe pain, which can delay the rehabilitation process and increase the risk of postoperative complications. Therefore, seeking a safe and effective postoperative analgesia is necessary for promoting the application of arthroscopic surgery. This protocol aims to detail a planned systematic review and meta-analysis on the comparative efficacy and safety of single-dose intra-articular injection of analgesics for pain relief after knee arthroscopy.Method and analysisPubMed, Embase, Web of Science and Cochrane Library will be searched from inception to 1 June 2020 to retrieve randomised controlled trials (RCTs) that compared the commonly used single-dose intra-articular analgesics (ie, morphine; bupivacaine (including levobupivacaine); ropivacaine and magnesium alone or in combination) with placebo or between each other for postoperative pain relief among patients who had received knee arthroscopy. The primary outcome is pain intensity at 2-hour and 24-hour postoperatively; the secondary outcomes include side effects (eg, knee effusion, nausea, vomiting and flushing), the number of patients requiring supplementary analgesia and the time to first analgesic request. The methodological quality of the included RCTs will be assessed based on the Cochrane risk of bias table. The Bayesian network meta-analysis will be conducted using WinBUGS V.1.4.3.Ethics and disseminationSince no private or confidential patient data will be contained in the reporting, approval from an ethics committee is not required. Our study raises no ethical issue, and the results will be published in a peer-reviewed journal.PROSPERO registration numberCRD42019130876.

scholarly journals Prospective, randomized, and comparative study of efficacy of ivermectin, benzyl benzoate 25%, permethrin 5% and gamma benzene hexachloride 1% in the treatment of uncomplicated scabies

2020 ◽  
Vol 9 (5) ◽  
pp. 712
Author(s):  
K. Chitra ◽  
Swathi Ratnam R. ◽  
J. Sudha ◽  
G. Suryanarayana
Keyword(s):  
Single Dose ◽  
Treatment Modalities ◽  
Efficacy And Safety ◽  
Single Application ◽  
Benzyl Benzoate ◽  
Chi Square ◽  
Medical College ◽  
Number Of Patients ◽  
Intergroup Comparison ◽  
Benzene Hexachloride

Background: Scabies is an infectious and contagious human skin disease. The aim of the study was to study the efficacy and safety of four different treatment modalities in clinically diagnosed cases of scabies of single dose of oral ivermectin and commonly used topical scabicidal agent’s benzyl benzoate 25% (BB), permethrin 5% and gamma benzene hexachloride 1% (GBHC).Methods: This study was carried out in the Department of Dermatology, Andhra Medical College, Visakhapatnam. 200 patients diagnosed of scabies were included in the study during the period from August 2013 to July 2014. The percentage of improvement was compared between four groups. Intergroup comparison between two groups was done Chi square test.Results: In the present study a greater number of patients were students (54.5%). Subsidence of lesion and itching with oral ivermectin given as a single dose (200 μg/kg body weight) was 45 (90%) and 44 (88%), with topical permethrin 5% lotion single application 48 (96%), 47 (94%), with topical GBHC 1% lotion 40 (80%) patients, 38 (76%). Topical application of BB lotion 25% was 38 (76%), and 36 (72%) at fourth week.Conclusions: In the present study permethrin 5% cream was found to be more effective among topical agents. Both BB and GBHC 1% lotion are being inexpensive and they can be used as an alternative treatment in developing country like India.

scholarly journals Evaluation of granisetron as an antiemetic in patients undergoing abdominal hysterectomy under spinal anaesthesia

2017 ◽  
Vol 5 (4) ◽  
pp. 1331
Author(s):  
Siddharth Uttam Nikam ◽  
Prakash N. Khandelwal ◽  
Ujwala B. Gawali
Keyword(s):  
Side Effects ◽  
Spinal Anaesthesia ◽  
Complete Response ◽  
Abdominal Hysterectomy ◽  
Efficacy And Safety ◽  
Post Surgery ◽  
Number Of Patients ◽  
Group B ◽  
Combined Spinal Epidural Anesthesia ◽  
Spinal Epidural

Background: PONV most common complications related to surgery and anaesthesia despite major advances in spinal, epidural and combined spinal-epidural anesthesia techniques IONV are still present in a significant number of patients. Ondansetron, used for controlling PONV induced by chemotherapy or radiation. Recently 5HT3 receptor antagonist granisetron has more potent, selective and longer acting activity than ondansetron. Granisetron is more active for control of PONV in cisplatin induced vomiting than ondansetron. It also reduces PONV in strabismus repair, tonsillectomy, and general surgeries, it has less side effects as compared to ondansetron. Objective of the study was to study efficacy and safety of granisetron and compare it with ondansetron for prevention of IONV and PONV.Methods: 80 ASA grade I and II women undergoing abdominal hysterectomy under spinal anaesthesia were studied. Patients in group A received injection granisetron 2 mg and group B injection ondansetron 4 mg,10 minutes prior to induction of spinal anaesthesia. Main outcome measures were occurrence of nausea, retching or vomiting in intraoperative and postoperative period at 6, 12, 18 and 24 hours’ post-surgery. The response of patient to therapy and side effects were evaluated in both groups. The results were analyzed by ‘z’ test (p<0.5) considered significant.Results: Demographic characteristics of both groups were comparable patients in granisetron (80%) had more complete response as compared to ondansetron (47.5%). Adverse effects were lower in granisetron group.Conclusions: Granisetron 2 Mg has better efficacy and safety profile than ondansetron 4 Mg.

Efficacy and Safety of Epoetin beta 30 000 IU Once Weekly in Anemic Patients with Non-Myeloid Malignancies Receiving Chemotherapy.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4281-4281
Author(s):  
Gandhi Damaj ◽  
Reda Garidi ◽  
Philippe Rodon ◽  
Dominique Bordessoule ◽  
Dominique Spaeth ◽  
...  
Keyword(s):  
Thromboembolic Event ◽  
Hematological Malignancies ◽  
Performance Status ◽  
Efficacy And Safety ◽  
Open Label ◽  
Myeloid Malignancies ◽  
Lymphoid Malignancies ◽  
Epoetin Beta ◽  
Number Of Patients ◽  
To Receive

Abstract Background: Once weekly (QW) epoetin beta (NeoRecormon®) 30 000 IU rapidly increases hemoglobin (Hb) levels and prevents transfusions in patients with lymphoid malignancies (Cazzola et al 2003). The aim of this study was to evaluate the efficacy and safety of epoetin beta 30 000 IU QW in patients with non-myeloid malignancies. Methods: Adult anemic patients (Hb 8–12 g/dl) with non-myeloid malignancies, WHO performance status 0–2 and who were scheduled to receive chemotherapy (CT) entered into this multicenter, open-label, single-arm study. Patients received epoetin beta 30 000 IU QW for 16 weeks. Primary efficacy endpoint was the % of Hb responders during epoetin beta therapy. Hb response was defined to account for the Hb level at baseline: Hb level of 13 g/dl achieved in patients with baseline Hb 11–12 g/dl or Hb increase of 2 g/dl and/or Hb level of 12 g/dl achieved in those with baseline Hb &lt; 11g/dl. Results: This analysis reports data of the first 98 patients (mean age 63.4 ± 12.4 years; 61% solid; 39% hematological malignancies). Overall, 67% of patients responded to epoetin beta treatment, with a greater number of patients with hematological malignancies (78.9%) obtaining a Hb response. Median time to response was 43 days. Mean Hb level at baseline was 10.1 ±1.04 g/dl. Hb levels increased to a mean of 12.8 ±1.75 g/dl over a median treatment period of 14 weeks with epoetin beta. Median Hb increase of 1.5 g/dl and 2 g/dl at 7 and 10 weeks, respectively, were recorded. A greater number of patients receiving non-platinum (Pt)-based CT responded (73.5%) than those receiving Pt-based CT (51.7%). At least one thromboembolic event (TEE) was observed in 5% of the patients. Only one TEE was considered to be related to the study treatment. Conclusions: Epoetin beta 30 000 IU QW is an effective and safe treatment of anemia in patients with non-myeloid malignancies, regardless of CT type and appears particularly effective in patients not receiving Pt-based CT or with hematological malignancies.

Comparative evaluation of efficacy and safety of etodolac and diclofenac sodium injection in patients with postoperative orthopedic pain

2011 ◽  
Vol 27 (11) ◽  
pp. 2107-2115 ◽  
Author(s):  
Anil Pareek ◽  
Nitin Chandurkar ◽  
Anil Gupta ◽  
Yatin Desai ◽  
Hiranya Kumar S. ◽  
...  
Keyword(s):  
Comparative Evaluation ◽  
Diclofenac Sodium ◽  
Efficacy And Safety

Comparison of two high doses of subcutaneous buprenorphine in cats undergoing ovariohysterectomy

2019 ◽  
Vol 24 (10) ◽  
pp. 504-514
Author(s):  
Rosa Leedham ◽  
Kate L White ◽  
David Yates ◽  
Lauren Brown
Keyword(s):  
Clinical Study ◽  
Acute Pain ◽  
Pain Scale ◽  
Rescue Analgesia ◽  
Physiological Variables ◽  
Blinded Observer ◽  
High Doses ◽  
Induction Of Anaesthesia ◽  
To Receive

Objectives: The aim of the study was to evaluate the analgesia and recovery effects of two doses (0.12 mg/kg and 0.24 mg/kg) of subcutaneous buprenorphine in cats undergoing ovariohysterectomy. Methods: This was an assessor-blinded, randomised, clinical study. A total of 83 cats were recruited and randomly allocated to receive 0.12 mg/kg buprenorphine or 0.24 mg/kg buprenorphine subcutaneously, followed 30 minutes later by 40 μg/kg medetomidine intramuscularly. Anaesthesia was induced with intravenous alfaxalone to effect and maintained with isoflurane in oxygen. All cats received meloxicam before surgery. Temperament score, quality of sedation, induction of anaesthesia, dose of alfaxalone and recovery were scored using simple descriptive scales. Atipamazole was administered following surgery. Physiological variables during anaesthesia were recorded. Cats were assessed postoperatively by the same blinded observer at 2, 4 and 24 hours using a modified Colorado Feline Acute Pain scale. The presence or absence of mydriasis was noted. Results: No significant differences were identified between groups. Three cats in the 0.12 mg/kg group and four in the 0.24 mg/kg group required rescue analgesia. Mydriasis persisting for at least 24 hours was evident in 75 cats. Conclusions and relevance: No differences in analgesia were detected between groups with these protocols; mydriasis was common in both groups.

Guide to Africa Bibliography

2020 ◽  
Vol 2019 ◽  
pp. xxix-xxx
Keyword(s):  
Social Sciences ◽  
Natural Sciences ◽  
Development Studies ◽  
Environmental Sciences ◽  
African Government ◽  
The Social ◽  
To Receive ◽  
Cover Material

This bibliography records publications on Africa of interest to students of Africa, principally in the social and environmental sciences, development studies, humanities and arts. Some items from the medical, biological and natural sciences are included. The criterion used is potential relevance to a reader from a social sciences/arts background. The whole continent and associated islands are covered, with selective coverage of the diaspora. This volume aims to cover material published in 2019 together with items from earlier years not previously listed. The editor is always very glad to hear of any items omitted so that they may be included in future volumes. He would be particularly pleased to receive notification of new periodicals, print or online. African government publications and works of creative literature are not normally listed.

scholarly journals A Comparison of Orally Administered Misoprostol With Vaginally Administered Misoprostol For Cervical Ripening And Labour Induction

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 668-672 ◽  
Author(s):  
Sohana Siddique ◽  
Muhammad Jahangir Howlader ◽  
Joysree Saha ◽  
Kazi Shahnaz Begum
Keyword(s):  
Mode Of Delivery ◽  
Cervical Ripening ◽  
Labour Induction ◽  
Efficacy And Safety ◽  
Cross Sectional ◽  
Oral Misoprostol ◽  
Number Of Patients ◽  
Oral Group ◽  
Vaginal Misoprostol ◽  
Duration Of Pregnancy

Objective: To compare efficacy and safety of oral misoprostol over vaginal misoprostol for labour induction.Materials and Methods: This is a cross sectional interventional hospital based comparative study which was carried in the department of Obstetrics and Gynecology in DMCH from 01.07.2008 to 31.12.2008.Results: Almost equal number of patients delivered vaginally spontaneously in both group, there is no association between route of administration and mode of delivery. Nausea,vomiting occurred more in oral group and uterine hypertonicity more in vaginal group.Conclusion: In this study, 50 patients were randomly selected for oral group and 50 patients for vaginal group. There were no significant differences regarding age, duration of pregnancy, Bishop's score and indication of induction of labour.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 668-672

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