Cocaine self-administration in rats influenced by environmental conditions: implications for the etiology of drug abuse

1987 ◽  
Vol 81 (1-2) ◽  
pp. 227-231 ◽  
Author(s):  
Susan Schenk ◽  
Gary Lacelle ◽  
Kathleen Gorman ◽  
Zalman Amit
Keyword(s):  
Drug Abuse ◽  
Environmental Conditions ◽  
Self Administration

scholarly journals THE COMPARATIVE STUDY OF CHILD DRUG ABUSE CASES

2021 ◽  
Vol 8 (2) ◽  
pp. 218
Author(s):  
Ibnu Taqwim ◽  
Pagar Hasibuan ◽  
Zulkarnain Zulkarnain
Keyword(s):  
Drug Abuse ◽  
Law Enforcement ◽  
Comparative Study ◽  
Environmental Conditions ◽  
Islamic Law ◽  
Drinking Alcohol ◽  
Islamic Perspective ◽  
The Family ◽  
Approach Method ◽  
The Comparative Study

The inconsistency of law enforcement in implementing the substance of the narcotics law has led to a polemic in the community, especially against cases of drug abuse committed by minors, it becomes unclear, the approach method used in this study uses a normative juridical approach. The research found that children as perpetrators of narcotics crimes, if they are not proven to be dealers, which can be dangerous as a basis for imprisonment for children, it is necessary to be rehabilitated as regulated in the narcotics law. Considering that children who are perpetrators of narcotics crimes are only users and are affected by bad environmental conditions both in the family and the environment. Narcotics in the Islamic perspective is analogous to the prohibition of drinking alcohol. This prohibition is carried out because narcotics cause hatred, hostility, disaster and dangerous disasters, both for users, families, communities and the nation and state. Narcotics are prohibited in Islamic law and producers, dealers and users will be subject to Had or Ta’zir sanctions.

Contingency management approaches to drug self-administration and drug abuse: Efficacy and limitations

1981 ◽  
Vol 6 (3) ◽  
pp. 241-252 ◽  
Author(s):  
George E. Bigelow ◽  
Maxine L. Stitzer ◽  
Roland R. Griffiths ◽  
Ira A. Liebson
Keyword(s):  
Drug Abuse ◽  
Contingency Management ◽  
Self Administration ◽  
Management Approaches

Less frequent causes of SCD (commotio cordis): non-cardiac causes (drug abuse, hyperpyrexia, rhabdomyolysis, sickle cell anaemia)—Part 1

2019 ◽  
pp. 328-332
Author(s):  
Erik Ekker Solberg ◽  
Paolo Emilio Adami
Keyword(s):  
Cardiac Arrest ◽  
Drug Abuse ◽  
Clinical Features ◽  
Sickle Cell ◽  
Environmental Conditions ◽  
Health Personnel ◽  
Sickle Cell Trait ◽  
Aortic Rupture ◽  
Sudden Cardiac Arrest ◽  
Commotio Cordis

It is important to be aware of the clinical features of less frequent causes of SCD in Europe (e.g. commotio cordis and aortic rupture) and non-cardiac causes (e.g. drug abuse, hyperpyrexia, rhabdomyolysis, sickle cell trait, asthma, and extreme environmental conditions). Lay people and health personnel may not understand the mechanisms leading to sudden cardiac arrest and therefore not act properly. This chapter describes these conditions and their relation to sudden cardiac arrest, and provides advice for prevention and action in actual cases.

Reinstatement of punishment-suppressed opioid self-administration in rats: an alternative model of relapse to drug abuse

2002 ◽  
Vol 168 (1-2) ◽  
pp. 229-235 ◽  
Author(s):  
Leigh V. Panlilio ◽  
Eric B. Thorndike ◽  
Charles W. Schindler
Keyword(s):  
Drug Abuse ◽  
Alternative Model ◽  
Self Administration

scholarly journals Do Prenatally Methamphetamine-Exposed Adult Male Rats Display General Predisposition to Drug Abuse in the Conditioned Place Preference Test?

2012 ◽  
pp. S129-S138
Author(s):  
R. ŠLAMBEROVÁ ◽  
M. POMETLOVÁ ◽  
B. SCHUTOVÁ ◽  
L. HRUBÁ ◽  
E. MACÚCHOVÁ ◽  
...  
Keyword(s):  
Drug Abuse ◽  
Pregnant Women ◽  
Conditioned Place Preference ◽  
Adult Male ◽  
Place Preference ◽  
Male Rats ◽  
Self Administration ◽  
Adult Rats ◽  
Drug Seeking ◽  
Seeking Behavior

Drug abuse of pregnant women is a growing problem. The effect of prenatal drug exposure may have devastating effect on development of the offsprings that may be long-term or even permanent. One of the most common drug abused by pregnant women is methamphetamine (MA), which is also the most frequently abused illicit drug in the Czech Republic. Our previous studies demonstrated that prenatal MA exposure alters behavior, cognition, pain and seizures in adult rats in sex-specific manner. Our most recent studies demonstrate that prenatal MA exposure makes adult rats more sensitive to acute injection of the same or related drugs than their controls. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult male rats tested in the Conditioned place preference (CPP). Adult male rats were divided to: prenatally MA-exposed (5 mg/kg daily for the entire prenatal period), prenatally saline-exposed (1 ml/kg of physiological saline) and controls (without maternal injections). The following drugs were used in the CPP test in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg), cocaine (5 and 10 mg/kg), morphine (5 mg/kg), MDMA (5 mg/kg) and THC (2 mg/kg). Our data demonstrated that prenatally MA-exposed rats displayed higher amphetamine-seeking behavior than both controls. MA as well as morphine induced drug-seeking behavior of adult male rats, however this effect did not differ based on the prenatal MA exposure. In contrast, prenatal MA exposure induced rather tolerance to cocaine than sensitization after the conditioning in the CPP. MDMA and THC did not induce significant effects. Even though the present data did not fully confirmed our hypotheses, future studies are planned to test the drug-seeking behavior also in self-administration test.

scholarly journals Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice

2013 ◽  
Vol 16 (7) ◽  
pp. 1559-1567 ◽  
Author(s):  
Yijin Yan ◽  
Yoshiaki Miyamoto ◽  
Atsumi Nitta ◽  
Shin-ichi Muramatsu ◽  
Keiya Ozawa ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Drug Abuse ◽  
Locomotor Activity ◽  
Gene Transfer ◽  
Mouse Models ◽  
Clinical Settings ◽  
Self Administration ◽  
Adeno Associated Virus ◽  
Gdnf Gene ◽  
The Brain

Abstract Relapse of drug abuse after abstinence is a major challenge to the treatment of addicts. In our well-established mouse models of methamphetamine (Meth) self-administration and reinstatement, bilateral microinjection of adeno-associated virus vectors expressing GDNF (AAV-Gdnf) into the striatum significantly reduced Meth self-administration, without affecting locomotor activity. Moreover, the intrastriatal AAV-Gdnf attenuated cue-induced reinstatement of Meth-seeking behaviour in a sustainable manner. In addition, this manipulation showed that Meth-primed reinstatement of Meth-seeking behaviour was reduced. These findings suggest that the AAV vector-mediated Gdnf gene transfer into the striatum is an effective and sustainable approach to attenuate Meth self-administration and Meth-associated cue-induced relapsing behaviour and that the AAV-mediated Gdnf gene transfer in the brain may be a valuable gene therapy against drug dependence and protracted relapse in clinical settings.

Less frequent causes of SCD (aortic rupture): non-cardiac causes (asthma, extreme environmental conditions (heat, cold, altitude))—Part 2

2019 ◽  
pp. 332-338 ◽  
Author(s):  
Erik Ekker Solberg ◽  
Paolo Emilio Adami
Keyword(s):  
Cardiac Arrest ◽  
Drug Abuse ◽  
Clinical Features ◽  
Sickle Cell ◽  
Environmental Conditions ◽  
Health Personnel ◽  
Sickle Cell Trait ◽  
Aortic Rupture ◽  
Sudden Cardiac Arrest ◽  
Commotio Cordis

It is important to be aware of the clinical features of less frequent causes of SCD in Europe (e.g. commotio cordis and aortic rupture) and non-cardiac causes (e.g. drug abuse, hyperpyrexia, rhabdomyolysis, sickle cell trait, asthma, and extreme environmental conditions). Lay people and health personnel may not understand the mechanisms leading to sudden cardiac arrest and therefore not act properly. This chapter is the second part of this topic and continues to describes these conditions their relation to SCA, and provides advice for prevention and action in actual cases.

Sign in / Sign up

Export Citation Format

Share Document