Effect of dietary ascorbic acid (vitamin C) supplementation on the performance of broiler chickens in a tropical environment

Ziel der Studie war es, die Auswirkungen der Aufnahme von drei verschiedenen Vitamin C-Mengen (0, 200 und 400 mg / kg) in die Ernährung auf das Fettsäureprofil im Broilerbrustfleisch zu bewerten. Die Studie wurde in 3 Zyklen und 4 Wiederholungen in Dauer von 42 Tagen durchgeführt, an einer vollständig randomisierten Probe von 10 Hühnern pro Käfig, insgesamt 120 männliche Hühner im Alter von einem Tag des kommerziellen Hybrids Ross 308. Die Datenanalyse wurde unter Verwendung des statistischen SAS-Analyseprogramms vorgenommen, während der Vergleich der Mittelwerte mit dem Duncan multiplen Vergleichstest mit einer Fehlerwahrscheinlichkeit von 5% durchgeführt wurde. Die Ergebnisse zeigten, dass die Zugabe von Vitamin C in einer Menge von 200 mg / kg den Prozentsatz an gesättigten Fettsäuren wie Myristinsäure, Palmitinsäure und Stearinsäure verringert, wobei die Menge an ungesättigten Fettsäuren zunahm und die Menge an gesättigten Fettsäuren abnahm

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Effect of Vitamin C Supplementation on Serum Ascorbic Acid Level and Liver Function Profile in Healthy Individuals

Asian Journal of Medicine and Health ◽

10.9734/ajmah/2020/v18i930235 ◽

2020 ◽

pp. 28-39

Author(s):

Iffat Nayila

Keyword(s):

Ascorbic Acid ◽

Liver Function ◽

Vitamin C ◽

Total Bilirubin ◽

Acid Supplementation ◽

Vitamin C Supplementation ◽

Group A ◽

Group B ◽

Function Profile ◽

Ascorbic Acid Supplementation

This study was conducted to explore the effects of ascorbic acid supplementation on serum liver function tests in healthy individuals. A total of 200 subjects were selected randomly. 100 were given ascorbic acid supplementation for 30 days. The other 100 were not given ascorbic acid supplementation, and serum ascorbic acid level and liver function profile was observed before and after intake of ascorbic acid in group A and without intake in group B. The liver function parameters determined were aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum total bilirubin, direct bilirubin, indirect bilirubin and serum protein (total protein, albumin and globulin). These parameters along with serum ascorbic acid were measured before and 30 days after vitamin C supplementation. Various parameters of liver function profile were improved swiftly when compared to other group which was not given ascorbic acid supplementation. While comparing the two treatment groups for 30 days, statistically significant improvement was seen in serum ascorbic acid levels (p<0.001) along with improvement in some components of liver function profile such as serum ALT (p<0.01), AST (p<0.01), Total Bilirubin (p<0.01) and Direct bilirubin (p<0.001), Total Proteins (p<0.01) and Albumin (p<0.001) in group A as compared to Group B (without vitamin C supplementation intake). Conclusively, Liver Functions were significantly improved with vitamin C supplementation, giving the supportive evidence of the use of vitamin C as an antioxidant.

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The effect of grape seed extract and vitamin C feed supplementation on some blood parameters and HSP70 gene expression of broiler chickens suffering from chronic heat stress

Italian Journal of Animal Science ◽

10.4081/ijas.2015.3273 ◽

2015 ◽

Vol 14 (3) ◽

Cited By ~ 13

Author(s):

Hosna Hajati ◽

Ahmad Hassanabadi ◽

Abolghasem Golian ◽

Hassan Nassiri-Moghaddam ◽

Mohammad Reza Nassiri

Keyword(s):

Gene Expression ◽

Heat Stress ◽

Vitamin C ◽

Broiler Chickens ◽

Stress Condition ◽

Grape Seed ◽

Blood Parameters ◽

Feed Supplementation ◽

Vitamin C Supplementation ◽

Heat Stress Condition

In this experiment, the effect of hydroalcoholic grape seed extract (GSE) and vitamin C feed supplementation on some blood parameters and heat shock protein 70 (<em>HSP70</em> gene) expression of broiler chickens suffering from chronic heat stress was investigated. Experimental diets included control diet (with no additive), 3 levels of GSE (150, 300, 450 mg/kg), and one level of vitamin C (300 mg/kg). Each diet was fed to 5 replicates of 12 male chicks each, from d 1 to 42. The birds suffered from chronic daily heat stress under 34±1°C temperature with 65 to 70% relative humidity for 5 h from 29 to 42 d of age. Results showed that 300 mg/kg GSE supplementation increased body weight of broilers both before and after heat stress condition (at 28 and 42 d, respectively). Also, birds fed 300 mg GSE/kg diet had higher European production efficiency factor during the whole period of the experiment. Supplementation of GSE decreased the concentration of serum glucose at 28 and 42 d; at 42 d (during heat stress condition) and at 450 mg/kg diet it decreased cholesterol, triglyceride, lowand very low density lipoprotein concentration of serum blood. Vitamin C supplementation decreased serum cholesterol concentration of broilers suffering from heat stress. <em>HSP70</em> gene expression in heart and liver of broilers reduced by GSE and vitamin C supplementation pre- and during chronic heat stress condition.

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Effect of different periods of chronic heat stress with or without vitamin C supplementation on bone and selected serum parameters of broiler chickens

Avian Pathology ◽

10.1080/03079457.2017.1401212 ◽

2017 ◽

Vol 47 (2) ◽

pp. 197-205 ◽

Cited By ~ 3

Author(s):

Najmeh Mosleh ◽

Tahoora Shomali ◽

Fahimeh Nematollahi ◽

Zahra Ghahramani ◽

Mohammad Saeid Ahrari Khafi ◽

...

Keyword(s):

Heat Stress ◽

Vitamin C ◽

Broiler Chickens ◽

Serum Parameters ◽

Vitamin C Supplementation

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Vitamin C supplementation in relation to inflammation in individuals with atrophic gastritis: a randomised controlled trial in Japan

British Journal Of Nutrition ◽

10.1017/s0007114512002954 ◽

2012 ◽

Vol 109 (6) ◽

pp. 1089-1095 ◽

Cited By ~ 5

Author(s):

Enbo Ma ◽

Shizuka Sasazuki ◽

Satoshi Sasaki ◽

Yoshitaka Tsubono ◽

Shunji Okubo ◽

...

Keyword(s):

Ascorbic Acid ◽

Randomised Controlled Trial ◽

Vitamin C ◽

Atrophic Gastritis ◽

Stomach Cancer ◽

Controlled Trial ◽

Dosage Group ◽

Vitamin C Supplementation ◽

Randomised Controlled ◽

Group 1

Evidence has shown that both C-reactive protein (CRP) and serum amyloid component A (SAA) are increased in individuals with gastritis and stomach cancer. Controlling the level of these biomarkers by inhibiting the gastric infection with high doses of ascorbic acid may reduce the risk of carcinogenesis. A population-based double-blind randomised controlled trial in a Japanese population with atrophic gastritis in an area of high stomach cancer incidence was conducted between 1995 and 2000. Daily doses of 50 or 500 mg vitamin C were given, and 120 and 124 participants completed the 5-year study, respectively. Although serum ascorbic acid was higher in the high-dosage group (1·73 (sd 0·46) μg/l) than in the low-dosage group (1·49 (sd 0·29) μg/l, P< 0·001), at the end of the study, no significant difference was observed for CRP between the low- and high-dosage groups (0·39 (95 % CI 0·04, 4·19) mg/l and 0·38 (95 % CI 0·03, 4·31) mg/l, respectively; P= 0·63) or for SAA between the low- and high-dosage groups (3·94 (95 % CI 1·04, 14·84) μg/ml and 3·85 (95 % CI 0·99, 14·92) μg/ml, respectively; P= 0·61). Vitamin C supplementation may not have a strong effect on reducing infections in individuals with atrophic gastritis.

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Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.00300.2011 ◽

2012 ◽

Vol 303 (1) ◽

pp. L20-L32 ◽

Cited By ~ 80

Author(s):

Bernard J. Fisher ◽

Donatas Kraskauskas ◽

Erika J. Martin ◽

Daniela Farkas ◽

Jacob A. Wegelin ◽

...

Keyword(s):

Ascorbic Acid ◽

Acute Lung Injury ◽

Lung Injury ◽

Vitamin C ◽

Epithelial Barrier ◽

Epithelial Permeability ◽

Alveolar Fluid Clearance ◽

Coagulation Abnormalities ◽

Junction Protein ◽

Vitamin C Supplementation

Bacterial infections of the lungs and abdomen are among the most common causes of sepsis. Abdominal peritonitis often results in acute lung injury (ALI). Recent reports demonstrate a potential benefit of parenteral vitamin C [ascorbic acid (AscA)] in the pathogenesis of sepsis. Therefore we examined the mechanisms of vitamin C supplementation in the setting of abdominal peritonitis-mediated ALI. We hypothesized that vitamin C supplementation would protect lungs by restoring alveolar epithelial barrier integrity and preventing sepsis-associated coagulopathy. Male C57BL/6 mice were intraperitoneally injected with a fecal stem solution to induce abdominal peritonitis (FIP) 30 min prior to receiving either AscA (200 mg/kg) or dehydroascorbic acid (200 mg/kg). Variables examined included survival, extent of ALI, pulmonary inflammatory markers (myeloperoxidase, chemokines), bronchoalveolar epithelial permeability, alveolar fluid clearance, epithelial ion channel, and pump expression (aquaporin 5, cystic fibrosis transmembrane conductance regulator, epithelial sodium channel, and Na+-K+-ATPase), tight junction protein expression (claudins, occludins, zona occludens), cytoskeletal rearrangements (F-actin polymerization), and coagulation parameters (thromboelastography, pro- and anticoagulants, fibrinolysis mediators) of septic blood. FIP-mediated ALI was characterized by compromised lung epithelial permeability, reduced alveolar fluid clearance, pulmonary inflammation and neutrophil sequestration, coagulation abnormalities, and increased mortality. Parenteral vitamin C infusion protected mice from the deleterious consequences of sepsis by multiple mechanisms, including attenuation of the proinflammatory response, enhancement of epithelial barrier function, increasing alveolar fluid clearance, and prevention of sepsis-associated coagulation abnormalities. Parenteral vitamin C may potentially have a role in the management of sepsis and ALI associated with sepsis.

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