Effects of vitamin C supplementation on plasma ascorbic acid and oxalate concentrations and meat quality in swine1

2004 ◽  
Vol 82 (7) ◽  
pp. 2004-2012 ◽  
Author(s):  
S. J. Pion ◽  
E. van Heugten ◽  
M. T. See ◽  
D. K. Larick ◽  
S. Pardue
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Meat Quality ◽  
Plasma Ascorbic Acid ◽  
Vitamin C Supplementation

scholarly journals Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study

Diabetologia ◽  
2019 ◽  
Vol 63 (2) ◽  
pp. 278-286 ◽  
Author(s):  
Markus Mattila ◽  
◽  
Iris Erlund ◽  
Hye-Seung Lee ◽  
Sari Niinistö ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Type 1 Diabetes ◽  
Vitamin C ◽  
Data Availability ◽  
Islet Autoimmunity ◽  
Plasma Ascorbic Acid ◽  
Background Population ◽  
Increased Risk ◽  
Nested Case Control

Abstract Aims/hypothesis We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes. Methods We used a risk set sampled nested case–control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched for family history of type 1 diabetes, clinical centre and sex. Plasma ascorbic acid concentration was measured at ages 6 and 12 months and then annually up to age 6 years. SNPs in vitamin C transport genes were genotyped using the ImmunoChip custom microarray. Comparisons were adjusted for HLA genotypes and for background population stratification. Results Childhood plasma ascorbic acid (mean ± SD 10.76 ± 3.54 mg/l in controls) was inversely associated with islet autoimmunity risk (adjusted OR 0.96 [95% CI 0.92, 0.99] per +1 mg/l), particularly islet autoimmunity, starting with insulin autoantibodies (OR 0.94 [95% CI 0.88, 0.99]), but not with type 1 diabetes risk (OR 0.93 [95% Cl 0.86, 1.02]). The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]). Conclusions/interpretation Higher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings. Data availability The datasets generated and analysed during the current study will be made available in the NIDDK Central Repository at https://www.niddkrepository.org/studies/teddy.

L-Ascorbic acid (vitamin C) supplementation to optimize health and reproduction in cattle

2012 ◽  
Vol 32 (3-4) ◽  
pp. 145-150 ◽  
Author(s):  
R. Ranjan ◽  
A. Ranjan ◽  
G.S. Dhaliwal ◽  
R.C. Patra
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Vitamin C Supplementation ◽  
Optimize Health

Maternal Plasma Ascorbic Acid (Vitamin C) and Risk of Gestational Diabetes Mellitus

Epidemiology ◽  
2004 ◽  
Vol 15 (5) ◽  
pp. 597-604 ◽  
Author(s):  
Cuilin Zhang ◽  
Michelle A. Williams ◽  
Tanya K. Sorensen ◽  
Irena B. King ◽  
Mark M. Kestin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Ascorbic Acid ◽  
Gestational Diabetes ◽  
Vitamin C ◽  
Gestational Diabetes Mellitus ◽  
Maternal Plasma ◽  
Plasma Ascorbic Acid

scholarly journals Effect of Vitamin C Supplementation on Serum Ascorbic Acid Level and Liver Function Profile in Healthy Individuals

2020 ◽  
pp. 28-39
Author(s):  
Iffat Nayila
Keyword(s):  
Ascorbic Acid ◽  
Liver Function ◽  
Vitamin C ◽  
Total Bilirubin ◽  
Acid Supplementation ◽  
Vitamin C Supplementation ◽  
Group A ◽  
Group B ◽  
Function Profile ◽  
Ascorbic Acid Supplementation

This study was conducted to explore the effects of ascorbic acid supplementation on serum liver function tests in healthy individuals. A total of 200 subjects were selected randomly. 100 were given ascorbic acid supplementation for 30 days. The other 100 were not given ascorbic acid supplementation, and serum ascorbic acid level and liver function profile was observed before and after intake of ascorbic acid in group A and without intake in group B. The liver function parameters determined were aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum total bilirubin, direct bilirubin, indirect bilirubin and serum protein (total protein, albumin and globulin). These parameters along with serum ascorbic acid were measured before and 30 days after vitamin C supplementation. Various parameters of liver function profile were improved swiftly when compared to other group which was not given ascorbic acid supplementation. While comparing the two treatment groups for 30 days, statistically significant improvement was seen in serum ascorbic acid levels (p<0.001) along with improvement in some components of liver function profile such as serum ALT (p<0.01), AST (p<0.01), Total Bilirubin (p<0.01) and Direct bilirubin (p<0.001), Total Proteins (p<0.01) and Albumin (p<0.001) in group A as compared to Group B (without vitamin C supplementation intake). Conclusively, Liver Functions were significantly improved with vitamin C supplementation, giving the supportive evidence of the use of vitamin C as an antioxidant.

The Rate of Increase of Blood Plasma Ascorbic Acid after Ingestion of Ascorbic Acid (Vitamin C)

1942 ◽  
Vol 23 (3) ◽  
pp. 309-319 ◽  
Author(s):  
E. Neige Todhunter ◽  
Ruth C. Robbins ◽  
Jennie A. McIntosh
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Blood Plasma ◽  
Plasma Ascorbic Acid ◽  
Rate Of Increase

scholarly journals Vitamin C supplementation in relation to inflammation in individuals with atrophic gastritis: a randomised controlled trial in Japan

2012 ◽  
Vol 109 (6) ◽  
pp. 1089-1095 ◽  
Author(s):  
Enbo Ma ◽  
Shizuka Sasazuki ◽  
Satoshi Sasaki ◽  
Yoshitaka Tsubono ◽  
Shunji Okubo ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Randomised Controlled Trial ◽  
Vitamin C ◽  
Atrophic Gastritis ◽  
Stomach Cancer ◽  
Controlled Trial ◽  
Dosage Group ◽  
Vitamin C Supplementation ◽  
Randomised Controlled ◽  
Group 1

Evidence has shown that both C-reactive protein (CRP) and serum amyloid component A (SAA) are increased in individuals with gastritis and stomach cancer. Controlling the level of these biomarkers by inhibiting the gastric infection with high doses of ascorbic acid may reduce the risk of carcinogenesis. A population-based double-blind randomised controlled trial in a Japanese population with atrophic gastritis in an area of high stomach cancer incidence was conducted between 1995 and 2000. Daily doses of 50 or 500 mg vitamin C were given, and 120 and 124 participants completed the 5-year study, respectively. Although serum ascorbic acid was higher in the high-dosage group (1·73 (sd 0·46) μg/l) than in the low-dosage group (1·49 (sd 0·29) μg/l, P< 0·001), at the end of the study, no significant difference was observed for CRP between the low- and high-dosage groups (0·39 (95 % CI 0·04, 4·19) mg/l and 0·38 (95 % CI 0·03, 4·31) mg/l, respectively; P= 0·63) or for SAA between the low- and high-dosage groups (3·94 (95 % CI 1·04, 14·84) μg/ml and 3·85 (95 % CI 0·99, 14·92) μg/ml, respectively; P= 0·61). Vitamin C supplementation may not have a strong effect on reducing infections in individuals with atrophic gastritis.

Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid

2012 ◽  
Vol 303 (1) ◽  
pp. L20-L32 ◽  
Author(s):  
Bernard J. Fisher ◽  
Donatas Kraskauskas ◽  
Erika J. Martin ◽  
Daniela Farkas ◽  
Jacob A. Wegelin ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Vitamin C ◽  
Epithelial Barrier ◽  
Epithelial Permeability ◽  
Alveolar Fluid Clearance ◽  
Coagulation Abnormalities ◽  
Junction Protein ◽  
Vitamin C Supplementation

Bacterial infections of the lungs and abdomen are among the most common causes of sepsis. Abdominal peritonitis often results in acute lung injury (ALI). Recent reports demonstrate a potential benefit of parenteral vitamin C [ascorbic acid (AscA)] in the pathogenesis of sepsis. Therefore we examined the mechanisms of vitamin C supplementation in the setting of abdominal peritonitis-mediated ALI. We hypothesized that vitamin C supplementation would protect lungs by restoring alveolar epithelial barrier integrity and preventing sepsis-associated coagulopathy. Male C57BL/6 mice were intraperitoneally injected with a fecal stem solution to induce abdominal peritonitis (FIP) 30 min prior to receiving either AscA (200 mg/kg) or dehydroascorbic acid (200 mg/kg). Variables examined included survival, extent of ALI, pulmonary inflammatory markers (myeloperoxidase, chemokines), bronchoalveolar epithelial permeability, alveolar fluid clearance, epithelial ion channel, and pump expression (aquaporin 5, cystic fibrosis transmembrane conductance regulator, epithelial sodium channel, and Na+-K+-ATPase), tight junction protein expression (claudins, occludins, zona occludens), cytoskeletal rearrangements (F-actin polymerization), and coagulation parameters (thromboelastography, pro- and anticoagulants, fibrinolysis mediators) of septic blood. FIP-mediated ALI was characterized by compromised lung epithelial permeability, reduced alveolar fluid clearance, pulmonary inflammation and neutrophil sequestration, coagulation abnormalities, and increased mortality. Parenteral vitamin C infusion protected mice from the deleterious consequences of sepsis by multiple mechanisms, including attenuation of the proinflammatory response, enhancement of epithelial barrier function, increasing alveolar fluid clearance, and prevention of sepsis-associated coagulation abnormalities. Parenteral vitamin C may potentially have a role in the management of sepsis and ALI associated with sepsis.

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