Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

Titania layer was fabricated on the titanium substrates with chemical treatment with 20ml or 40ml of hydrogen peroxide solution and subsequent heat treatment at 400°C, coded as CHT20 and CHT40, respectively. CHT20 spontaneously deposited apatite on the surface in a simulated body fluid (SBF), while CHT40 did not. TF-XRD patterns showed that the diffraction intensity of anatase of CHT20 was higher than that of CHT40. It was suggested that the thicker titania layer indicated in vitro apatite forming ability. The cell proliferation of CHT20 and CHT40 were lower than NT and HT. Since the surface of titania layers became hydrophobic after autoclaving, we can suppose that the cell proliferation on CHT20 and CHT40 were lower than NT and HT due to their surface hydrophobicity.

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Role of Intracellular pH in Mammalian Cell Proliferation

Cellular Physiology and Biochemistry ◽

10.1159/000154638 ◽

1992 ◽

Vol 2 (3-4) ◽

pp. 159-179 ◽

Cited By ~ 38

Author(s):

R.J. Gillies ◽

R. Martinez-Zaguilan ◽

E.P. Peterson ◽

R. Perona

Keyword(s):

Cell Proliferation ◽

Intracellular Ph ◽

Mammalian Cell

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Mammalian Cell Proliferation is Regulated by the Synergistic Actions of Multiple Growth Factors

Advances in Experimental Medicine and Biology - Hormones and Cancer ◽

10.1007/978-1-4615-7192-6_16 ◽

1982 ◽

pp. 287-300

Author(s):

W. J. Pledger ◽

C. A. Hart ◽

W. R. Wharton

Keyword(s):

Cell Proliferation ◽

Growth Factors ◽

Mammalian Cell

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The 7-Deazaguanine Derivative, Queuine, Regulates Mammalian Cell Proliferation Depending on the Metabolic State

Advances in Experimental Medicine and Biology - Chemistry and Biology of Pteridines and Folates ◽

10.1007/978-1-4615-2960-6_51 ◽

1993 ◽

pp. 251-254

Author(s):

Werner Langgut ◽

Marianne Haupt ◽

Thomas Reisser

Keyword(s):

Cell Proliferation ◽

Mammalian Cell ◽

Metabolic State

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Long-range memory of growth and cycle progression correlates cell cycles in lineage trees

10.1101/373258 ◽

2018 ◽

Cited By ~ 5

Author(s):

Erika E Kuchen ◽

Nils Becker ◽

Nina Claudino ◽

Thomas Höfer

Keyword(s):

Cell Cycle ◽

Cell Proliferation ◽

Cell Growth ◽

Mammalian Cell ◽

Latent Variable ◽

Cycle Length ◽

Growth Control ◽

Minimum Size ◽

Cell Cycles ◽

Lineage Trees

Mammalian cell proliferation is controlled by mitogens. However, how proliferation is coordinated with cell growth is poorly understood. Here we show that statistical properties of cell lineage trees – the cell-cycle length correlations within and across generations – reveal how cell growth controls proliferation. Analyzing extended lineage trees with latent-variable models, we find that two antagonistic heritable variables account for the observed cycle-length correlations. Using molecular perturbations of mTOR and MYC we identify these variables as cell size and regulatory license to divide, which are coupled through a minimum-size checkpoint. The checkpoint is relevant only for fast cell cycles, explaining why growth control of mammalian cell proliferation has remained elusive. Thus, correlated fluctuations of the cell cycle encode its regulation.

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