Ferritin and hemosiderin in pathological tissues

1992 ◽  
Vol 5 (2) ◽  
pp. 209-229 ◽  
Author(s):  
Theodore C. Iancu
Keyword(s):  
Author(s):  
Valentina Russo ◽  
Roberto Setola

The aim of this chapter is to provide an overview about models and methodologies used for the Dynamic Contrast Enhancement (DCE) analysis. DCE is a non-invasive methodology aimed to diagnostic the nature of a lesion on the base of the perfusion’s dynamic of specific contrast agents. The idea at the base of DCE is that, in several pathological tissues, including tumors and inflammatory diseases, the angiogenic process is abnormal, hence the characterization of vascularisation structure may be used to support the diagnosis. In this chapter, we will describe the basic DCE procedures and introduce some of its most innovative evolution based on the pharmacokinetic analysis technique (PK), and the empirical model (EM). Even if DCE is still a medical research topic, there is large interest for this type of approach in biomedical applications as witnessed by the availability of specific tools in the last generation top-class US, CT and MR machines.


1966 ◽  
Vol 52 (4) ◽  
pp. 283-293
Author(s):  
Salvatore Di Bella ◽  
Umberto Pinchierri ◽  
Gabriella Richetta

The oxidation rate of citrate, d,1-isocitrate, glucose-6-phosphate and phosphogluconate proceeded two fold more rapidly in slices of rat skin with tumors induced by 7,12-dimethylbenz[a]anthracene than in normal skin. Citrate oxidation was stimulated by addition either of Fe++ or of cysteine, which, when both present in the system, are able to avoid the aconitase inactivation in the tissue. Mn++, NADP, FMN and cytocrome c may activate the oxygen uptake both in normal and pathological tissues, using as substrates respectively citrate, d,1-isocitrate, glucose-6-phosphate or phosphogluconate. The isocitric-dehydrogenase activity of the extracts of tumor induced rat skin resulted lower than that observed in normal rat skin; glucose-6-phosphate and respectively phosphogluconate-dehydrogenase enzymatic levels were two fold higher in the neoplastic than in the normal skin rat extracts. The results presented show an increase of the oxidative carbohydrate metabolism and pentosephosphate shunt, during carcinogenesis in the rat skin.


2019 ◽  
Vol 16 (156) ◽  
pp. 20190023 ◽  
Author(s):  
Taisiya Sigaeva ◽  
Michel Destrade ◽  
Elena S. Di Martino

The opening angle method is a popular choice in biomechanics to estimate residual stresses in arteries. Experimentally, it means that an artery is cut into rings; then the rings are cut axially or radially allowing them to open into sectors; finally, the corresponding opening angles are measured to give residual stress levels by solving an inverse problem. However, for many tissues, for example in pathological tissues, the ring does not open according to the theory into a neat single circular sector, but rather creates an asymmetric geometry, often with abruptly changing curvature(s). This phenomenon may be due to a number of reasons including variation in thickness, microstructure, mechanical properties, etc. As a result, these samples are often eliminated from studies relying on the opening angle method, which limits progress in understanding and evaluating residual stresses in real arteries. With this work, we propose an effective approach to deal with these non-trivial openings of rings. First, we digitize pictures of opened rings to split them into multiple, connected circular sectors. Then we measure the corresponding opening angles for each sub-sector. Subsequently, we can determine the residual stresses for individual sectors in a closed-ring configuration and, thus, approximate the circumferential residual bending effects.


1979 ◽  
Vol 6 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Yoshiaki Hori ◽  
Shichiro Miyazawa ◽  
Shigeo Nishiyama ◽  
Mikio Miyata ◽  
Satoshi Ishikawa

1997 ◽  
Author(s):  
Ousama M. A'Amar ◽  
Francois H. Guillemin ◽  
Henri Begorre ◽  
Edouard Yvroud

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