A Double-Antibody Radioimmunoassay for Soluble and Cell-Surface Blood Group Ii Antigens

1979 ◽  
pp. 1095-1097
Author(s):  
Edwin Wood ◽  
Jacqueline Lecomte ◽  
Robert Childs ◽  
Ten Feizi
Keyword(s):  
Cell Surface ◽  
Blood Group ◽  
Double Antibody ◽  
Group Ii

scholarly journals Association of ABO blood groups with presentation and outcomes of confirmed SARS CoV-2 infection: A prospective study in the largest COVID-19 dedicated hospital in Bangladesh

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249252
Author(s):  
Reaz Mahmud ◽  
Mohammad Aftab Rassel ◽  
Farhana Binte Monayem ◽  
S. K. Jakaria Been Sayeed ◽  
Md Shahidul Islam ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Duration Of Symptoms ◽  
Presenting Symptoms ◽  
Blood Group A ◽  
Group I ◽  
Significant Difference ◽  
Group A ◽  
Group Ii

Background Globally, studies have shown conflicting results regarding the association of blood groups with SARS CoV-2 infection. Objective To observe the association between ABO blood groups and the presentation and outcomes of confirmed COVID-19 cases. Design, setting, and participants This was a prospective cohort study of patients with mild-to-moderately severe COVID-19 infections who presented in the COVID-19 unit of Dhaka Medical College Hospital and were enrolled between 01 June and 25 August, 2020. Patients were followed up for at least 30 days after disease onset. We grouped participants with A-positive and A-negative blood groups into group I and participants with other blood groups into group II. Results The cohort included 438 patients; 52 patients were lost to follow-up, five died, and 381 completed the study. The prevalence of blood group A [144 (32.9%)] was significantly higher among COVID-19 patients than in the general population (p < 0.001). The presenting age [mean (SD)] of group I [42.1 (14.5)] was higher than that of group II [38.8 (12.4), p = 0.014]. Sex (p = 0.23) and co-morbidity (hypertension, p = 0.34; diabetes, p = 0.13) did not differ between the patients in groups I and II. No differences were observed regarding important presenting symptoms, including fever (p = 0.72), cough (p = 0.69), and respiratory distress (p = 0.09). There was no significant difference in the median duration of symptoms in the two group (12 days), and conversion to the next level of severity was observed in 26 (20.6%) and 36 patients (13.8%) in group I and II, respectively. However, persistent positivity of RT-PCR at 14 days of initial positivity was more frequent among the patients in group I [24 (19%)] than among those in group II [29 (11.1%)]. Conclusions The prevalence of blood group A was higher among COVID-19 patients. Although ABO blood groups were not associated with the presentation or recovery period of COVID-19, patients with blood group A had delayed seroconversion.

scholarly journals Plasma blood group glycosyltransferase activities after bone marrow transplantation

Blood ◽  
1980 ◽  
Vol 55 (4) ◽  
pp. 699-701 ◽  
Author(s):  
A Yoshida ◽  
GM Schmidt ◽  
KG Blume ◽  
E Beutler
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Cell Surface ◽  
Blood Group ◽  
Marrow Transplantation ◽  
Primary Source ◽  
Blood Type ◽  
Red Cell ◽  
Complete Replacement ◽  
Group B

Human blood groups (ABO) are known to be determined by the terminal glycosyl residues attached to common carbohydrate chains of the red cell surface. N-acetylgalactosaminyltransferase (A-enzyme) in blood group A persons and galactosyltransferase (B-enzyme) in blood group B persons are responsible for producing A and B substances on the red cell surface, with both enzymes absent in blood group O persons. The plasma transferase (A - and B-) activity was assayed after the complete replacement of the bone marrow of patients with acute leukemia or aplastic anemia by transplantation bone marrow from donors with ABO blood group differing from the recipient. The patient's blood type completely changed from the recipient's type to the donor's type. However, the A- and B-enzyme activities of the patients changed only slightly after bone marrow transplantation. The results indicate that most of the A- and B-enzymes in the circulatory plasma is not derived from the bone marrow, lymphoid, or macrophage tissue. Other tissues must be the primary source of the enzymes in plasma.

Interaction ofVicia gramineaAnti-N Lectin with Cell Surface Glycoproteins from Erythrocytes with Rare Blood Group Antigens

1984 ◽  
Vol 365 (1) ◽  
pp. 469-478 ◽  
Author(s):  
Dominique BLANCHARD ◽  
Alain ASSERAF ◽  
Marie José PRiGENT ◽  
John J. MOULDS ◽  
Dasnayanee CHANDANAYINGYONG ◽  
...  
Keyword(s):  
Cell Surface ◽  
Blood Group ◽  
Blood Group Antigens ◽  
Cell Surface Glycoproteins ◽  
Surface Glycoproteins

scholarly journals Plasma blood group glycosyltransferase activities after bone marrow transplantation

Blood ◽  
1980 ◽  
Vol 55 (4) ◽  
pp. 699-701 ◽  
Author(s):  
A Yoshida ◽  
GM Schmidt ◽  
KG Blume ◽  
E Beutler
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Cell Surface ◽  
Blood Group ◽  
Marrow Transplantation ◽  
Primary Source ◽  
Blood Type ◽  
Red Cell ◽  
Complete Replacement ◽  
Group B

Abstract Human blood groups (ABO) are known to be determined by the terminal glycosyl residues attached to common carbohydrate chains of the red cell surface. N-acetylgalactosaminyltransferase (A-enzyme) in blood group A persons and galactosyltransferase (B-enzyme) in blood group B persons are responsible for producing A and B substances on the red cell surface, with both enzymes absent in blood group O persons. The plasma transferase (A - and B-) activity was assayed after the complete replacement of the bone marrow of patients with acute leukemia or aplastic anemia by transplantation bone marrow from donors with ABO blood group differing from the recipient. The patient's blood type completely changed from the recipient's type to the donor's type. However, the A- and B-enzyme activities of the patients changed only slightly after bone marrow transplantation. The results indicate that most of the A- and B-enzymes in the circulatory plasma is not derived from the bone marrow, lymphoid, or macrophage tissue. Other tissues must be the primary source of the enzymes in plasma.

Cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Lactobacillus plantarum LA 318 recognizes human A and B blood group antigens

2008 ◽  
Vol 159 (9-10) ◽  
pp. 685-691 ◽  
Author(s):  
Hideki Kinoshita ◽  
Nozomi Wakahara ◽  
Masamichi Watanabe ◽  
Tomomi Kawasaki ◽  
Hiroki Matsuo ◽  
...  
Keyword(s):  
Cell Surface ◽  
Lactobacillus Plantarum ◽  
Blood Group ◽  
Blood Group Antigens ◽  
B Blood Group

Probing Cell Surface “Glyco-Architecture” through Total Synthesis. Immunological Consequences of a Human Blood Group Determinant in a Clustered Mucin-like Context

1999 ◽  
Vol 121 (45) ◽  
pp. 10636-10637 ◽  
Author(s):  
Peter W. Glunz ◽  
Samuel Hintermann ◽  
Jacob B. Schwarz ◽  
Scott D. Kuduk ◽  
Xiao-Tao Chen ◽  
...  
Keyword(s):  
Cell Surface ◽  
Total Synthesis ◽  
Blood Group ◽  
Human Blood ◽  
Human Blood Group

scholarly journals ABO blood group glycans modulate sialic acid recognition on erythrocytes

Blood ◽  
2009 ◽  
Vol 114 (17) ◽  
pp. 3668-3676 ◽  
Author(s):  
Miriam Cohen ◽  
Nancy Hurtado-Ziola ◽  
Ajit Varki
Keyword(s):  
Sialic Acid ◽  
Cell Surface ◽  
Blood Group ◽  
Binding Proteins ◽  
Microbial Interactions ◽  
Blood Type ◽  
Malarial Parasite ◽  
Erythrocyte Membranes ◽  
Influenza Hemagglutinin ◽  
Cell Surface Glycans

Abstract ABH(O) blood group polymorphisms are based on well-known intraspecies variations in structures of neutral blood cell surface glycans in humans and other primates. Whereas natural antibodies against these glycans can act as barriers to blood transfusion and transplantation, the normal functions of this long-standing evolutionary polymorphism remain largely unknown. Although microbial interactions have been suggested as a selective force, direct binding of lethal pathogens to ABH antigens has not been reported. We show in this study that ABH antigens found on human erythrocytes modulate the specific interactions of 3 sialic acid-recognizing proteins (human Siglec-2, 1918SC influenza hemagglutinin, and Sambucus nigra agglutinin) with sialylated glycans on the same cell surface. Using specific glycosidases that convert A and B glycans to the underlying H(O) structure, we show ABH antigens stabilize sialylated glycan clusters on erythrocyte membranes uniquely for each blood type, generating differential interactions of the 3 sialic acid-binding proteins with erythrocytes from each blood type. We further show that by stabilizing such structures ABH antigens can also modulate sialic acid-mediated interaction of pathogens such as Plasmodium falciparum malarial parasite. Thus, ABH antigens can noncovalently alter the presentation of other cell surface glycans to cognate-binding proteins, without themselves being a direct ligand.

scholarly journals Blood-group-Ii-active gangliosides of human erythrocyte membranes

1978 ◽  
Vol 173 (1) ◽  
pp. 245-254 ◽  
Author(s):  
T Feizi ◽  
R A Childs ◽  
S I Hakomori ◽  
M E Powell
Keyword(s):  
Blood Group ◽  
Silica Gel ◽  
Human Erythrocyte ◽  
Porous Silica ◽  
Erythrocyte Membranes ◽  
Group I ◽  
Internal Structures ◽  
Human Erythrocyte Membranes ◽  
Porous Silica Gel ◽  
Group Ii

More than ten new types of gangliosides, in addition to haematoside and sialosylparagloboside, were isolated from human erythrocyte membranes. These were separated by successive chromatographies on DEAE-Sephadex, on porous silica-gel columns and on thin-layer silica gel as acetylated compounds. Highly potent blood-group-Ii and moderate blood-group-H activities were demonstrated in some of the ganglioside fractions. The gangliosides incorporated into cholesterol/phosphatidylcholine liposomes stoicheiometrically inhibited binding of anti-(blood-group I and i) antibodies to a radioiodinated blood-group-Ii-active glycoprotein. The fraction with the highest blood-group-I-activity, I(g) fraction, behaved like sialosyl-deca- to -dodeca-glycosylceramides on t.l.c. Certain blood-group-I and most of the -i determinants were in partially or completely cryptic form and could be unmasked by sialidase treatment. Thus the I and i antigens, which are known to occur on internal structures of blood-group-ABH-active glycoproteins in secretions, also occur in the interior of the carbohydrate chains of erythrocyte gangliosides.

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