Dietary Factors and the Epigenetics of Fatty Liver Disease

2021 ◽  
pp. 404-408
Author(s):  
Malihe Saeidi ◽  
Amandio Vieira
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Dietary Factors

scholarly journals The Role of Resolvins, Protectins and Marensins in Non-Alcoholic Fatty Liver Disease (NAFLD)

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 937
Author(s):  
Dominika Maciejewska-Markiewicz ◽  
Ewa Stachowska ◽  
Viktoria Hawryłkowicz ◽  
Laura Stachowska ◽  
Piotr Prowans
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Liver Lipid ◽  
Dietary Factors ◽  
Alcoholic Fatty Liver ◽  
Dietary Components ◽  
Alcoholic Fatty Liver Disease ◽  
Docosahexaenoic Acids

Increased triacylglycerols’ (TAG) synthesis, insulin resistance, and prolonged liver lipid storage might lead to the development of non-alcoholic fatty liver disease (NAFLD). Global prevalence of NAFLD has been estimated to be around 25%, with gradual elevation of this ratio along with the increased content of adipose tissue in a body. The initial stages of NAFLD may be reversible, but the exposition to pathological factors should be limited. As dietary factors greatly influence various disease development, scientists try to find dietary components, helping to alleviate the steatosis. These components include n-3 polyunsaturated (PUFA) fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA). This review focused on the role of resolvins, protectins and merensins in NAFLD.

Dietary Factors in the Pathogenesis and Care of Patients with Fatty Liver Disease

2013 ◽  
pp. 248-259
Author(s):  
Giulio Marchesini ◽  
Rebecca Marzocchi ◽  
Anna S. Sasdelli ◽  
Cristiana Andruccioli ◽  
Silvia Di Domizio
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Dietary Factors

scholarly journals Effects of coenzyme Q10 supplementation on the anthropometric variables, lipid profiles and liver enzymes in patients with non-alcoholic fatty liver disease

2015 ◽  
Vol 11 (1) ◽  
pp. 35 ◽  
Author(s):  
Elnaz Jafarvand ◽  
Mahdieh Abbasalizad Farhangi ◽  
Beytollah Alipour ◽  
Manouchehr Khoshbaten
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Coenzyme Q10 ◽  
Fatty Liver Disease ◽  
Controlled Trial ◽  
Intervention Group ◽  
Serum Triglyceride ◽  
Dietary Factors ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

<p class="Abstract">This randomized double-blind placebo-controlled trial was conducted on 41 patients with non-alcoholic fatty liver disease. Patients in intervention group received 100 mg/day coenzyme Q10 (CoQ10) for four weeks. There was a significant reduction in waist circumference and aspartate aminotransferase concentrations after CoQ10 supplementation (p&lt;0.05). Dietary fiber was in negative correlation with change in serum alanine aminotransferase (ALT) concentrations (r = -410, p = 0.04), and dietary fat intake was in positive relation with serum triglyceride (r = 463, p = 0.04) and in negative relation with serum high-density lipoprotein cholesterol (HDL-C) (r = -533, p = 0.02) in CoQ10-treated group. CoQ10 supplement is able to reduce central obesity and improve liver function in non-alcoholic fatty liver disease. Dietary factors were also significant determinants of change in liver-specific enzyme ALT and lipid profile in these patients. Further trials with higher dose of CoQ10 and longer treatment periods are warranted to better clarify these findings.</p><p> </p>

scholarly journals The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease

2021 ◽  
Vol 27 (1) ◽  
pp. 22-43
Author(s):  
Erica Jennison ◽  
Christopher D. Byrne
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Dietary Factors ◽  
Current Evidence ◽  
Alcoholic Fatty Liver ◽  
Close Relationship ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. The pathogenesis of NAFLD is complex and multifactorial, involving environmental, genetic and metabolic factors. The role of the diet and the gut microbiome is gaining interest as a significant factor in NAFLD pathogenesis. Dietary factors induce alterations in the composition of the gut microbiome (dysbiosis), commonly reflected by a reduction of the beneficial species and an increase in pathogenic microbiota. Due to the close relationship between the gut and liver, altering the gut microbiome can affect liver functions; promoting hepatic steatosis and inflammation. This review summarises the current evidence supporting an association between NAFLD and the gut microbiome and dietary factors. The review also explores potential underlying mechanisms underpinning these associations and whether manipulation of the gut microbiome is a potential therapeutic strategy to prevent or treat NAFLD.

Association of Pro-inflammatory Dietary Intake and Non-Alcoholic Fatty Liver Disease: Findings from Iranian case-control study

2018 ◽  
Vol 88 (3-4) ◽  
pp. 144-150 ◽  
Author(s):  
Farhad Vahid ◽  
Nitin Shivappa ◽  
Azita Hekmatdoost ◽  
James R Hebert ◽  
Hossein Poustchi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Dietary Intake ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Continuous Variable ◽  
Dietary Factors ◽  
Major Health Problem ◽  
Alcoholic Fatty Liver ◽  
Incident Cases ◽  
Alcoholic Fatty Liver Disease

Abstract. Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is considered as a major health problem in the world. There is much evidence that diet and dietary factors play an important role in inflammation, and consequently pathogenesis of NAFLD. To investigate the role of diet in the development of inflammation, we can use the Dietary Inflammatory Index (DII), which has been shown to be predictive of levels of inflammatory markers. Methods: 295 incident cases were selected using the convenience-sampling procedure, and 704 controls randomly were selected from the same clinic and among the patients who had no hepatic steatosis and were frequency-matched on age (±5 years) and sex. The DII was computed based on dietary intake from 168-item FFQ. Logistic regression models were used to estimate multivariable ORs. Results: Subjects in tertile 3 had 1.57 (95% CI: 1.13–2.20), 1.78 (95% CI: 1.19–2.67), and 2.02 (95% CI: 1.32–3.09) times higher odds of developing NAFLD, compared to subjects in tertile 1 in models 1 (adjusted for age), 2 (model 1 + BMI, education, smoking, alcohol, diabetes, low density lipoprotein, triglycerides) and 3 (model 2 + aspartate transaminase/alanine transaminase), respectively. When used as a continuous variable, one unit increase in DII was associated with 1.16 (95% CI: 1.05, 1.29), 1.21 (95% CI: 1.107, 1.37) and 1.25 (95% CI: 1.10, 1.43) increase in odds of NAFLD in models one, 2 and 3 respectively. Conclusion: Subjects who consumed a more pro-inflammatory diet were at increased odds of NAFLD.

scholarly journals Diagnosis of Non-alcoholic fatty liver disease

2016 ◽  
Vol 6 (11) ◽  
pp. 947-952
Author(s):  
Geetika K.C.
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Steatohepatitis ◽  
Fatty Liver Disease ◽  
Scoring Systems ◽  
Dietary Factors ◽  
Biochemical Tests ◽  
Alcoholic Fatty Liver ◽  
Simple Steatosis ◽  
Alcoholic Fatty Liver Disease

Non Alcoholic Fatty Liver Disease is the deposition of fat in liver in absence of excessive of alcohol consumption. Non Alcoholic Fatty Liver Disease ranges from simple steatosis to Nonalcoholic steatohepatitis and cirrhosis. Most cases (90%) of Non Alcoholic Fatty Liver Disease have simple steatosis with benign prognosis. Ten to thirty percent of Non -Alcoholic Fatty Liver Disease progresses to NASH and 25-40% of Nonalcoholic steatohepatitis undergoes progressive liver fibrosis.Ultimately 20-30% of Nonalcoholic steatohepatitis will go into cirrhosis during their lifetime. Nonalcoholic steatohepatitis cirrhosis has higher chances of (2.6% per year) going into hepatocellular carcinoma. There are several risk factors noted for Non Alcoholic Fatty Liver Disease. Some of which includes increasing age, metabolic syndrome, dietary factors etc. Investigations regarding liver function test can be divided into invasive and noninvasive types. Under invasive procedures comes liver biopsy and non-invasive includes radiological tests and various biochemical tests. This article tries to analyze different scoring systems and their significance in diagnosing steatohepatitis and fibrosis. 

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