scholarly journals Exploring the Relationship of Drugs/Dietary Factors/Obesity in Occurence of Nonalcoholic Fatty Liver Disease

Author(s):  
Rajashree Samal,
Medicine ◽  
2017 ◽  
Vol 96 (39) ◽  
pp. e8164 ◽  
Author(s):  
Xiao-Long Yu ◽  
Long Shu ◽  
Xiao-Ming Shen ◽  
Xiao-Yan Zhang ◽  
Pei-Fen Zheng

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 600 ◽  
Author(s):  
Oral ◽  
Sahin ◽  
Turker ◽  
Kocak

Background and objectives: Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as hypertension, diabetes, dyslipidemia, obesity, and hyperuricemia. We aim to investigate the relationship between uric acid and NAFLD in a non-obese and young population. Materials and Methods: This study was performed in January 2010–2019 with a group of 367 (225 patients in the NAFLD group and 142 in the control group) patients with liver biopsy-proven NAFLD or no NAFLD. Patients with NAFLD were classified according to the percentage of steatosis as follows, group I had 1–20% and group II >20%. Demographic, clinical, and laboratory (biochemical parameters) features were collected retrospectively. Results: The mean body mass index (BMI) and age of the patients were 26.41 ± 3.42 and 32.27 ± 8.85, respectively. The BMI, homeostatic model of assessment (HOMA-IR), and uric acid (UA) values of the NAFLD group were found to be significantly higher than those of the controls. A positive correlation was found between the NAFLD stage and UA. The following factors were independently associated with NAFLD: BMI, HOMA-IR, and UA. In addition, the cut-off value of UA was 4.75 mg/dl with a sensitivity of 45.8% and a specificity of 80.3%. Conclusions: UA is a simple, non-invasive, cheap, and useful marker that may be used to predict steatosis in patients with NAFLD.


Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 91
Author(s):  
Yuanqiang Ma ◽  
Gyurim Lee ◽  
Su-Young Heo ◽  
Yoon-Seok Roh

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.


2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Sanhang Wang ◽  
Hu Jiu lüe ◽  
Jiao Zhao

During the onset of nonalcoholic fatty liver disease (NAFLD), the original deficiency is the root cause of its occurrence, and the actual condition is the basic condition for its occurrence. Therefore, the correlation between the deficiency and the actual condition is the basic law of NAFL syndrome formation, pathogenesis, development, and change. Based on this, the purpose of this article is to study and analyze the syndrome intervention of NAFLD from the perspective of the original deficiency and the true standard. In this article, the TCM physical fitness determination and related risk factors investigation were conducted on qualified NAFLD patients collected from outpatient clinics and physical examination centers of a certain local hospital. Analyze the correlation between the physique bias, physique type, and risk factors of NAFLD patients, in order to effectively carry out Chinese medicine “preventive treatment” in the future. Predicting the risk of nonalcoholic fatty liver disease from the perspective of physique, more targeted health education for NAFLD patients with risk factors, reducing the risk of nonalcoholic fatty liver disease, and providing evidence for prevention and treatment of fatty liver. The research in this article aims to show a clearer conclusion on the structural characteristics of NAFLD’s syndromes related to the deficiency of the original standard and the actual syndromes or the syndromes related to the original deficiency of the standard of the actual syndromes; NAFLD has the characteristics of being related to the original deficiency and the actual standard, and the relationship between the original deficiency and the actual standard has different syndromes, and the relationship between the original deficiency and the actual standard can also show the characteristics of different subsyndromes. Experimental research shows that people with hot and humid constitution are prone to suffer from hyperglycemia, intermediate coke hot and heat obstruction, spleen and stomach clearance, and turbidity reduction function is impaired, and the migration and transformation of water and valley essence after the stomach is uneven, leading to the stagnation of water, wet, phlegm, blood stasis, and other pathological products.


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