Vibrational imaging of proteins: changes in the tissues and cells in the lifestyle disease studies

Author(s):  
Katarzyna Majzner ◽  
Krzysztof Czamara ◽  
Marta Z. Pacia ◽  
Jakub Dybas ◽  
Ewelina Bik ◽  
...  
Keyword(s):  
Author(s):  
Sara Hayee ◽  
Amna Rehman

Caner a dreadful disease is actually one large group of diseases which dates back to times of “Hippocrates”, The Father of Medicine, (460-370BC) who used this name for the first time to talk about non-ulcer and ulcer forming tumors. Theevidence of its presence from the very past history comes from fossilized “Egyptian Mummies” having tumors on bones. Then Galen (130-200 AD) used the term “Oncos” to explain tumors. So it's a disease involving growth of abnormal cells, their proliferation and metastasizing the other tissues and organs. Now we know that biology has a branch namedOncology to deal with the scientific study of cancer and oncogenes. It took centuries to get knowledge and use modern technologies against this malady. Now we know cancer is a group disease which has hundreds of types. 19th Century saw much advancement towards its cure. Along with surgery, radiotherapy and chemotherapy were the main methods to cure cancer patients. Day by day, scientists are looking for new methods to control and cure of this curse. Hundreds of natural medicinal compounds are being tested to use clinically for its cure in order to replace the radiotherapy andchemotherapy and lower their side effects. But humanity is still fighting against this disease as the numbers of cases throughout the world are increasing day by day. If we look on the reports p r e s e n t e d b y W H O ( W o r l d H e a l t hOrganization), Cancer is the second leading cause of deaths globally which means one person in every six deaths, dies due to cancer. In 2018, the most common types of cancers reported in men were of liver, prostate, stomach, lung andcolorectal. Whereas in females the most common forms were breast, thyroid, cervical and colorectal. Cancer has become a global disasterfamily of the patient. It imparts physical, emotional and financial crisis. Unfortunately, the condition is bitterer in under developing countries. Cancer has become a lifestyle disease these days. We are living in the world withsuperficial comfort but we are breathing with urbanizations, ozone depletion, exposure to microwave and ultraviolet radiations, hazardous chemicals etc. Moreover, It is becoming a lifestyle disease due to lack of exercise, Obesity, consumptions of drugs, tobacco and alcohols. The cases of cancers are reported more in urban areas than in rural areasmore likely due to above mentioned factors. The ratio of cancer patients is expected to raise up-to 27.5 million by 2040 globally. So the battle is never ending, Humans need to figure out the factors and cutting these from their lives in orderto live a healthy life which is a blessing indeed. which is not only crunching the cancer patient but it also has damaging effects on the whole


Mobile technology is showing a wide acceptance in the health-care system. As technology is changing there are many health-care applications in the market. The need of these applications is increasing day by day because of unhealthy lifestyle. Among the various ailments, the most common lifestyle disease is diabetes. As we know diabetes can’t be cured, it can only be controlled by managing one’s lifestyle. In this paper, we propose a new application DiaM for managing and mentoring a diabetic patient. DiaM is Artificial Intelligence (AI) based mobile application which not only connect to manage one’s lifestyle but to build the strong will power. Our application has been designed in such a way that all the aspects are covered to manageone’s lifestyle. We have implemented an AI based system which smartly categorizes the patients in different states, which utilizes the different parameter like eating habit, stress, exercise, sleep time, smoking, genetic, BMI, and various other symptoms. On the basis of these states suggestions are been provided to the patient for improving the lifestyle. DiaM also enables patient to connect with the Doctor for monitoring and mentoring. Our application provides real-time alerts to doctor so that they can monitor patient anytime. It is extremely necessary to manage health conditions therefore our application provides a better,accurate and sustainable healthcare system.


BMJ ◽  
2008 ◽  
Vol 336 (7650) ◽  
pp. 952.1-953 ◽  
Author(s):  
Ian T Gilmore
Keyword(s):  

2019 ◽  
Vol 47 (4) ◽  
pp. 1165-1172 ◽  
Author(s):  
Paul G. Shiels ◽  
Sarah Buchanan ◽  
Colin Selman ◽  
Peter Stenvinkel

Abstract Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an increasingly aged global population. Accelerated biological ageing is a feature of age-related morbidities, which also appear to share common underpinning features, including low-grade persistent inflammation, phosphate toxicity, diminished Nrf2 activity, a depleted metabolic capability, depressed mitochondrial biogenesis and a low diversity gut microbiome. Social, psychological, lifestyle and nutritional risk factors can all influence the trajectory of age-related health, as part of an individual's exposome, which reflects the interplay between the genome and the environment. This is manifest as allostatic (over)load reflecting the burden of lifestyle/disease at both a physiological and molecular level. In particular, age-related genomic methylation levels and inflammatory status reflect exposome differences. These features may be mediated by changes in microbial diversity. This can drive the generation of pro-inflammatory factors, such as TMAO, implicated in the ‘diseasome’ of ageing. Additionally, it can be influenced by the ‘foodome’, via nutritional differences affecting the availability of methyl donors required for maintenance of the epigenome and by the provision of nutritionally derived Nrf2 agonists. Both these factors influence age-related physiological resilience and health. This offers novel insights into possible interventions to improve health span, including a rage of emerging senotherapies and simple modifications of the nutritional and environmental exposome. In essence, the emerging strategy is to treat ageing processes common to the diseasome of ageing itself and thus preempt the development or progression of a range of age-related morbidities.


2019 ◽  
Vol 51 (7) ◽  
pp. S51-S52
Author(s):  
Etsuko Kibayashi ◽  
Makiko Nakade ◽  
Yukiko Nobuki ◽  
Natsumi Yamawaki ◽  
Ayumi Morooka

2016 ◽  
Vol 04 (01) ◽  
pp. 041-043 ◽  
Author(s):  
Arun Kumar ◽  
Manohar Bhatia ◽  
Pawan Goel ◽  
Ram Jain

AbstractDiabetes mellitus (DM), commonly regarded as a lifestyle disease, used to be a disease of affluent societies in the days of yore. However, now it has encroached into the rural and tribal communities as well. This narrative review provides us with an understanding of the epidemiology of diabetes burden in tribes of India. Around 15% of the country′s area is covered by tribals and it constitutes ~8.6% (i. e., ~104 million) of India′s total population. Prevalence of diabetes in tribal areas ranges from around 1% to 10%. Hence, intensive efforts directed towards filling the gaps in awareness levels and the operational research or other data gaps would help prevent and control the problem of diabetes and fill these gaps in tribal areas.


2019 ◽  
Vol 15 (4) ◽  
Author(s):  
Katarzyna Dziergowska ◽  
Magdalena Beata Łabowska ◽  
Marlena Gąsior-Głogowska ◽  
Barbara Kmiecik ◽  
Jerzy Detyna

AbstractThis paper presents the current state of the art of noninvasive glucose monitoring. In recent years, we can observe constant increase in the incidence of diabetes. About 40% of all performed blood tests apply to the glucose tests. Formerly, this lifestyle disease occurred mainly in rich countries, but now it is becoming more common in poorer countries. It is related to the increase in life expectancy, unhealthy diet, lack of exercise, and other factors. Untreated diabetes may cause many complications or even death. For this reason, daily control of glucose levels in people with this disorder is very important. Measurements with a traditional glucometer are connected with performing finger punctures several times a day, which is painful and uncomfortable for patients. Therefore, researches on other methods are ongoing. A method that would be fast, noninvasive and cheap could also enable testing the state of the entire population, which is necessary because of the number of people currently living with undiagnosed type 2 diabetes. Although the first glucometer was made in 1966, the first studies on glucose level measurement in tear film were documented as early as 1937. This shows how much a noninvasive method of diabetes control is needed. Since then, there have been more and more studies on alternative methods of glucose measurement, not only from tear fluid, but also from saliva, sweat, or transdermally.


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