The potential role of adipose derived stem cells as semi-permanent/permanent fillers in aesthetic surgery

2009 ◽  
pp. 107-119 ◽  
Author(s):  
Marc H. Hedrick ◽  
John K. Fraser ◽  
Kevin C. Hicok
Keyword(s):  
Stem Cells ◽  
Potential Role ◽  
Aesthetic Surgery ◽  
Adipose Derived Stem Cells ◽  
Permanent Fillers

scholarly journals Oncogenic Linear Collagen VI of Invasive Breast Cancer Is Induced by CCL5

2020 ◽  
Vol 9 (4) ◽  
pp. 991 ◽  
Author(s):  
Elizabeth Brett ◽  
Matthias Sauter ◽  
Éadaoin Timmins ◽  
Omid Azimzadeh ◽  
Michael Rosemann ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Potential Role ◽  
Dermal Fibroblasts ◽  
Adipose Derived Stem Cells ◽  
Mechanism Of Formation ◽  
Collagen Vi

The triple-negative breast tumor boundary is made of aligned, linear collagen. The pro-oncogenic impact of linear collagen is well established; however, its mechanism of formation is unknown. An in vitro analogue of the tumor border is created by a co-culture of MDA-MB-231 cells, adipose derived stem cells, and dermal fibroblasts. Decellularization of this co-culture after seven days reveals an extracellular matrix that is linear in fashion, high in pro-oncogenic collagen type VI, and able to promote invasion of reseeded cells. Further investigation revealed linear collagen VI is produced by fibroblasts in response to a paracrine co-culture of adipose derived stem cells and MDA-MB-231, which together secrete high levels of the chemokine CCL5. The addition of monoclonal antibody against CCL5 to the co-culture results in an unorganized matrix with dramatically decreased collagen VI. Importantly, reseeded cells do not exhibit pro-oncogenic behavior. These data illustrate a cellular mechanism, which creates linear extracellular matrix (ECM) in vitro, and highlight a potential role of CCL5 for building striated tumor collagen in vivo.

scholarly journals The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery

2016 ◽  
Vol 14 (1) ◽  
pp. 112-124 ◽  
Author(s):  
Naghmeh Naderi ◽  
Emman J Combellack ◽  
Michelle Griffin ◽  
Tina Sedaghati ◽  
Muhammad Javed ◽  
...  
Keyword(s):  
Stem Cells ◽  
Reconstructive Surgery ◽  
Adipose Derived Stem Cells ◽  
Plastic And Reconstructive Surgery

scholarly journals Fat graft – the natural choice for reconstructive, regenerative and aesthetic surgery

2017 ◽  
Vol 5 (2) ◽  
pp. 113-117
Author(s):  
Samir Ibrahim ◽  
Joanna Rybacka-Mossakowska ◽  
Sławomir Michalak
Keyword(s):  
Stem Cells ◽  
Donor Site ◽  
Aesthetic Surgery ◽  
Fat Grafting ◽  
Fat Graft ◽  
Clinical Effects ◽  
Adipose Derived Stem Cells ◽  
Safe Alternative ◽  
Natural Choice ◽  
Reconstructive Operations

AbstractThe search for appropriate filler, which can be used for aesthetic and reconstructive operations is currently one of challenges for plastic surgery. The application of absorbable and permanent artificial fillers may cause adverse events. Thus, autologous fat grafting can be a safe alternative. Moreover, fat tissue is rich in adipose-derived stem cells (ASC), which can be successfully used for regenerative procedures. The paper reviews reports on fat grafting procedures, which indicate risks and their possible prophylactic.Adipose tissue is a much more prolific source of ASCs than bone marrow. Basically, ASC are characterized by a spectrum of markers: CD11b-CD45-CD13+CD73+CD90+, which can be widened by CD36+CD-106-CD10+CD26+CD49d+CD49e+CD3-D49f -PODXL- to improve phenotyping. It is suggested to use at least two negative markers and two positive markers during the same phenotyping analysis. Fat transfer requires appropriate approach, planning and technique to make it clinically successful.Fat grafting fulfills the expectations for ideal injectable agent, which can be used for aesthetic and reconstructive surgery. To improve the survival of fat graft, careful decisions on donor site, local anesthetic administration, liposuction method, processing and placement methods need to be made. Moreover, fat is the source of adipose-derived stem cells which can be used for regenerative procedures. A proper transformation and identification of those cells is required to improve clinical effects.

Stem Cells from Human Exfoliated Deciduous Teeth and their Promise as Preventive and Therapeutic Strategies for Neurological Diseases and Injuries

2021 ◽  
Vol 17 ◽  
Author(s):  
Lingyi Huang ◽  
Zizhuo Zheng ◽  
Ding Bai ◽  
Xianglong Han
Keyword(s):  
Stem Cells ◽  
Potential Role ◽  
Neurological Diseases ◽  
Therapeutic Strategies ◽  
Deciduous Teeth ◽  
Research Attention ◽  
Considerable Potential ◽  
Prevention And Treatment ◽  
Human Exfoliated Deciduous Teeth

Abstract: Stem cells from human exfoliated deciduous teeth (SHEDs) are relatively easy to isolate from exfoliated deciduous teeth, which are obtained via dental therapy as biological waste. SHEDs originate from the embryonic neural crest and therefore have considerable potential for neurogenic differentiation. Currently, an increasing amount of research attention is focused on the therapeutic applications of SHEDs in neurological diseases and injuries. In this article, we summarize the biological characteristics of SHEDs and the potential role of SHEDs and their derivatives, including conditioned medium from SHEDs and the exosomes they secrete, in the prevention and treatment of neurological diseases and injuries.

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