Integrin β4 | ScienceGate

Integrin β4 (ITGβ4) is a class of transmembrane adhesion molecules composed of hemidesmosomes (HDs). Its unique long intracellular domain provides intricate signal transduction functions. These signal transduction effects are especially prominent in tumors. Many recent studies have shown that integrin β4 is differentially expressed in various tumors, and it plays a vital role in tumor invasion, proliferation, epithelial–mesenchymal transition, and angiogenesis. Therefore, we categorize the research related to integrin β4, starting from its structure and function in tumor tissues, and provide a basic description. Based on its structure and function, we believe that integrin β4 can be used as a tumor marker. In clinical practice, it is described as a diagnostic marker for the targeted treatment of cancer and will be helpful in the clinical diagnosis and treatment of tumors.

Download Full-text

Caspase Proteolysis of the Integrin β4 Subunit Disrupts Hemidesmosome Assembly, Promotes Apoptosis, and Inhibits Cell Migration

Journal of Biological Chemistry ◽

10.1074/jbc.m603669200 ◽

2006 ◽

Vol 282 (8) ◽

pp. 5560-5569 ◽

Cited By ~ 21

Author(s):

Michael E. Werner ◽

Feng Chen ◽

Jose V. Moyano ◽

Fruma Yehiely ◽

Jonathan C. R. Jones ◽

...

Keyword(s):

Cell Migration ◽

Integrin Β4

Download Full-text

Integrin β4 Expression in the Neoplastic Progression of Cervical Epithelium

Gynecologic Oncology ◽

10.1006/gyno.1993.1087 ◽

1993 ◽

Vol 49 (1) ◽

pp. 61-66 ◽

Cited By ~ 28

Author(s):

Elisabetta Carico ◽

Deborah French ◽

Barbara Bucci ◽

Rita Falcioni ◽

Aldo Vecchione ◽

...

Keyword(s):

Neoplastic Progression ◽

Cervical Epithelium ◽

Integrin Β4

Download Full-text

Integrin β4–Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis

Cancer Research ◽

10.1158/0008-5472.can-19-1145 ◽

2019 ◽

Vol 80 (4) ◽

pp. 771-783 ◽

Cited By ~ 1

Author(s):

Shasha Ruan ◽

Ming Lin ◽

Yong Zhu ◽

Lawrence Lum ◽

Archana Thakur ◽

...

Keyword(s):

Tumor Growth ◽

Inhibit Tumor Growth ◽

Integrin Β4 ◽

Cancer Immunotherapies

Download Full-text

Effect of Hydrothermal Treatment with Distilled Water on Titanium Alloy for Epithelial Cellular Attachment

Materials ◽

10.3390/ma12172748 ◽

2019 ◽

Vol 12 (17) ◽

pp. 2748 ◽

Cited By ~ 1

Author(s):

Yasushige Sakamoto ◽

Yasunori Ayukawa ◽

Akihiro Furuhashi ◽

Michimasa Kamo ◽

Junji Ikeda ◽

...

Keyword(s):

Hydrothermal Treatment ◽

Distilled Water ◽

Water Contact ◽

Long Term Stability ◽

Cellular Attachment ◽

Integrin Β4 ◽

Oral Epithelial ◽

Laminin 332 ◽

Surface Crystal

The enhancement of oral epithelial adhesion to the trans-mucosal material of dental implants may improve their long-term stability. The aim of this study is to investigate whether hydrothermal treatment with distilled water (HT-DW) applied to a Ti-6Al-4V (Ti64) alloy could improve epithelial cellular attachment. We hypothesized that this treatment would enhance the adsorption of proteins and the adhesion of gingival epithelial GE1 cells. This treatment changed the surface crystal structure into an anatase type of titanium oxide without an apparent change of surface roughness or topography. Nitrogen was not detected on the HT-DW-treated Ti64, which indicates decontamination. HT-DW-treated Ti64 exhibited a hydrophilic surface with a less than 10° angle of water contact. Adsorption of laminin-332 to the HT-DW-treated Ti64 was significantly greater than that of the untreated Ti64 plates (64). The number of GE1 cells on the HT-DW-treated Ti64 at 1 and 3 days was significantly lower than that on 64; however, cell adhesion strength on HT-DW was greater, with a higher expression of integrin β4, compared with 64. This indicates that the HT-DW treatment of Ti64 improves the integration of GE1 cells, which might facilitate the development of a soft tissue barrier around the implant.

Download Full-text