Molecular epidemiology of yellow fever virus in Africa: A perspective of the phylogeographic split between East/Central African and West African lineages

Acta Tropica ◽  
2021 ◽  
pp. 106199
Author(s):  
Yan Li
Keyword(s):  
Molecular Epidemiology ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
West African ◽  
Fever Virus ◽  
East Central

scholarly journals Genome analysis and phylogenetic relationships between east, central and west African isolates of Yellow fever virus

2006 ◽  
Vol 87 (4) ◽  
pp. 895-907 ◽  
Author(s):  
Jana J. von Lindern ◽  
Sarah Aroner ◽  
Nicholas D. Barrett ◽  
Jason A. Wicker ◽  
C. Todd Davis ◽  
...  
Keyword(s):  
Amino Acid ◽  
Yellow Fever ◽  
Genome Analysis ◽  
Yellow Fever Virus ◽  
Prototype Strain ◽  
West African ◽  
Fever Virus ◽  
Full Genome ◽  
Genome Database ◽  
East Central

Yellow fever virus (YFV), a reemerging disease agent in Africa and South America, is the prototype member of the genus Flavivirus. Based on examination of the prM/M, E and 3′ non-coding regions of the YFV genome, previous studies have identified seven genotypes of YFV, including the Angolan, east/central African and east African genotypes, which are highly divergent from the prototype strain Asibi. In this study, full genome analysis was used to expand upon these genetic relationships as well as on the very limited full genome database for YFV. This study was the first to investigate genomic sequences of YFV strains from east and central Africa (Angola71, Uganda48a and Ethiopia61b). All three viruses had genomes of 10 823 nt in length. Compared with the prototype strain Asibi (from west Africa) they were approximately 25 % divergent in nucleotide sequence and 7 % divergent in amino acid sequence. Comparison of multiple flaviviruses in the N-terminal region of NS4B showed that amino acid sequences were variable and that west African strains of YFV had an amino acid deletion at residue 21. Additionally, N-linked glycosylation sites were conserved between viral genotypes, while codon usage varied between strains.

scholarly journals Genetic Relationships and Evolution of Genotypes of Yellow Fever Virus and Other Members of the Yellow Fever Virus Group within the Flavivirus Genus Based on the 3′ Noncoding Region

2004 ◽  
Vol 78 (18) ◽  
pp. 9652-9665 ◽  
Author(s):  
John-Paul Mutebi ◽  
René C. A. Rijnbrand ◽  
Heiman Wang ◽  
Kate D. Ryman ◽  
Eryu Wang ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Genetic Relationships ◽  
West African ◽  
Fever Virus ◽  
Genetic Group ◽  
Noncoding Region ◽  
South American ◽  
Sequence Elements

ABSTRACT Genetic relationships among flaviviruses within the yellow fever (YF) virus genetic group were investigated by comparing nucleotide sequences of the 3′ noncoding region (3′NCR). Size heterogeneity was observed between members and even among strains of the same viral species. Size variation between YF strains was due to duplications and/or deletions of repeated nucleotide sequence elements (RYF). West African genotypes had three copies of the RYF (RYF1, RYF2, and RYF3); the Angola and the East and Central African genotypes had two copies (RYF1 and RYF3); and South American genotypes had only a single copy (RYF3). Nucleotide sequence analyses suggest a deletion within the 3′NCR of South American genotypes, including RYF1 and RYF2. Based on studies with the French neurotropic vaccine strain, passage of a YF virus strain in cell culture can result in deletion of RYF1 and RYF2. Taken together, these observations suggest that South American genotypes of YF virus evolved from West African genotypes and that the South American genotypes lost RYF1 and RYF2, possibly in a single event. Repeated sequence elements were found within the 3′NCR of other members of the YF virus genetic group, suggesting that it is probably characteristic for members of the YF virus genetic group. A core sequence of 15 nucleotides, containing two stem-loops, was found within the 3′NCR of all members of the YF genetic group and may represent the progenitor repeat sequence. Secondary structure predictions of the 3′NCR showed very similar structures for viruses that were closely related phylogenetically.

scholarly journals Yellow fever virus outbreak in Brazil under current and future climate

2021 ◽  
Vol 6 ◽  
pp. 664-677
Author(s):  
Tara Sadeghieh ◽  
Jan M. Sargeant ◽  
Amy L. Greer ◽  
Olaf Berke ◽  
Guillaume Dueymes ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Future Climate

scholarly journals Yellow Fever Outbreak in Eastern Senegal, 2020–2021

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1475
Author(s):  
Moussa Moïse Diagne ◽  
Marie Henriette Dior Ndione ◽  
Alioune Gaye ◽  
Mamadou Aliou Barry ◽  
Diawo Diallo ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Mosquito Species ◽  
Virus Transmission ◽  
Genomic Analysis ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
World Health ◽  
Effective Vaccine ◽  
Ministry Of Health

Yellow fever virus remains a major threat in low resource countries in South America and Africa despite the existence of an effective vaccine. In Senegal and particularly in the eastern part of the country, periodic sylvatic circulation has been demonstrated with varying degrees of impact on populations in perpetual renewal. We report an outbreak that occurred from October 2020 to February 2021 in eastern Senegal, notified and managed through the synergistic effort yellow fever national surveillance implemented by the Senegalese Ministry of Health in collaboration with the World Health Organization, the countrywide 4S network set up by the Ministry of Health, the Institut Pasteur de Dakar, and the surveillance of arboviruses and hemorrhagic fever viruses in human and vector populations implemented since mid 2020 in eastern Senegal. Virological analyses highlighted the implication of sylvatic mosquito species in virus transmission. Genomic analysis showed a close relationship between the circulating strain in eastern Senegal, 2020, and another one from the West African lineage previously detected and sequenced two years ago from an unvaccinated Dutch traveler who visited the Gambia and Senegal before developing signs after returning to Europe. Moreover, genome analysis identified a 6-nucleotide deletion in the variable domain of the 3′UTR with potential impact on the biology of the viral strain that merits further investigations. Integrated surveillance of yellow fever virus but also of other arboviruses of public health interest is crucial in an ecosystem such as eastern Senegal.

YELLOW FEVER VIRUS

1929 ◽  
Vol 92 (7) ◽  
pp. 550 ◽  
Author(s):  
HENRIQUE DE BEAUREPAIRE ARAGÃO
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus

Complete nucleotide sequence of yellow fever virus vaccine strains 17DD and 17D-213

1995 ◽  
Vol 35 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Claudia N. Duarte dos Santos ◽  
Paulo R. Post ◽  
Ricardo Carvalho ◽  
Idevaldo I. Ferreira ◽  
Charles M. Rice ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Yellow Fever ◽  
Virus Vaccine ◽  
Complete Nucleotide Sequence ◽  
Yellow Fever Virus ◽  
Fever Virus
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