scholarly journals The possible role of cerium oxide (CeO2) nanoparticles in prevention of neurobehavioral and neurochemical changes in 6-hydroxydopamine-induced parkinsonian disease

2017 ◽  
Vol 53 (4) ◽  
pp. 351-360 ◽  
Author(s):  
Maha Abd Elkader Hegazy ◽  
Hala Mohamed Maklad ◽  
Doaa A. Abd Elmonsif ◽  
Fatma Yosry Elnozhy ◽  
Malik Ahmad Alqubiea ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Ceo2 Nanoparticles ◽  
Neurochemical Changes ◽  
6 Hydroxydopamine ◽  
Parkinsonian Disease

scholarly journals The Protective Role of Brain CYP2J in Parkinson’s Disease Models

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Yueran Li ◽  
Jinhua Wu ◽  
Xuming Yu ◽  
Shufang Na ◽  
Ke Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Regions ◽  
Protective Role ◽  
Neural Cells ◽  
Endogenous Substrates ◽  
6 Hydroxydopamine ◽  
Myd88 Signaling ◽  
Lps Treatment

CYP2J proteins are present in the neural cells of human and rodent brain regions. The aim of this study was to investigate the role of brain CYP2J in Parkinson’s disease. Rats received right unilateral injection with lipopolysaccharide (LPS) or 6-hydroxydopamine (6-OHDA) in the substantia nigra following transfection with or without the CYP2J3 expression vector. Compared with LPS-treated rats, CYP2J3 transfection significantly decreased apomorphine-induced rotation by 57.3% at day 12 and 47.0% at day 21 after LPS treatment; moreover, CYP2J3 transfection attenuated the accumulation of α-synuclein. Compared with the 6-OHDA group, the number of rotations by rats transfected with CYP2J3 decreased by 59.6% at day 12 and 43.5% at day 21 after 6-OHDA treatment. The loss of dopaminergic neurons and the inhibition of the antioxidative system induced by LPS or 6-OHDA were attenuated following CYP2J3 transfection. The TLR4-MyD88 signaling pathway was involved in the downregulation of brain CYP2J induced by LPS, and CYP2J transfection upregulated the expression of Nrf2 via the inhibition of miR-340 in U251 cells. The data suggest that increased levels of CYP2J in the brain can delay the pathological progression of PD initiated by inflammation or neurotoxins. The alteration of the metabolism of the endogenous substrates (e.g., AA) could affect the risk of neurodegenerative disease.

scholarly journals Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making

2009 ◽  
Vol 29 (8) ◽  
pp. 1678-1691 ◽  
Author(s):  
Mark E. Walton ◽  
James Groves ◽  
Katie A. Jennings ◽  
Paula L. Croxson ◽  
Trevor Sharp ◽  
...  
Keyword(s):  
Decision Making ◽  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
6 Hydroxydopamine

scholarly journals The Roll of NaPSS Surfactant on the Ceria Nanoparticles Embedding in Polypyrrole Films

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Simona Popescu ◽  
Mihaela Mîndroiu ◽  
Daniela Cabuzu ◽  
Cristian Pîrvu
Keyword(s):  
Cerium Oxide ◽  
Antibacterial Effect ◽  
Electrochemical Behaviour ◽  
Titanium Substrate ◽  
Crystalline Form ◽  
Polymeric Films ◽  
Ceria Nanoparticles ◽  
Polypyrrole Films ◽  
Polymerization Conditions

Cerium oxide nanoparticles (CeO2NPs) in crystalline form have been synthesized by a coprecipitation method. CeO2nanoparticles were then embedded in polypyrrole (PPy) films during the electropolymerization of pyrrole (Py) on titanium substrate. The influence of poly(sodium 4-styrenesulfonate) (NaPSS) surfactant used during polymerization on the embedding of CeO2NPs in polypyrrole films was investigated. The new films were characterized in terms of surface analysis, wettability, electrochemical behaviour, and antibacterial effect. The surface and electrochemical characterization revealed the role of surfactant on PPy doping process cerium oxide incorporation. In the presence of surfactant, CeO2NPs are preferentially embedded in the polymeric film while, without surfactant, the ceria nanoparticles are quasiuniformly spread as agglomerates onto polymeric films. The antibacterial effect of studied PPy films was substantially improved in the presence of cerium oxide and depends by the polymerization conditions.

Synthesis and Characterization of Cerium Oxide (CeO2) Nanoparticles

2009 ◽  
Vol 609 ◽  
pp. 189-194 ◽  
Author(s):  
C. Benmouhoub ◽  
A. Kadri ◽  
N. Benbrahim ◽  
S. Hadji
Keyword(s):  
Crystallite Size ◽  
Cerium Oxide ◽  
Ceo2 Nanoparticles ◽  
Precipitation Method ◽  
Synthesis And Characterization

Nanoparticles of cerium oxide (CeO2) are synthesized with cerium (III) nitrates (Ce(NO3)3, 6H2O) by precipitation method in ammonium hydroxyl solution (NH4OH). The influence of several parameters such as nature of the solvent, synthesizing temperature and the calcination on the crystallite size is studied by XRD, TEM and BET methods. The results show that both calcinations and synthesizing temperature affect the particles size. Also, the nature of solvent has a great effect on the morphology of CeO2 nanoparticles.

scholarly journals Erectile response to hypothalamic stimulation in rats: role of peripheral nerves

1997 ◽  
Vol 273 (6) ◽  
pp. R1990-R1997 ◽  
Author(s):  
François Giuliano ◽  
Jacques Bernabé ◽  
Kathleen Brown ◽  
Stéphane Droupy ◽  
Gérard Benoit ◽  
...  
Keyword(s):  
Peripheral Nerves ◽  
Pressure Ratio ◽  
Cauda Equina ◽  
Sympathetic Chain ◽  
Iliac Arteries ◽  
Pelvic Nerves ◽  
Arterial Inflow ◽  
Erectile Response ◽  
6 Hydroxydopamine

The role of peripheral parasympathetic and sympathetic pathways was explored in erectile responses elicited by hypothalamic medial preoptic area (MPOA) stimulation in adult male anesthetized rats. Under control conditions, MPOA stimulation reliably elicited erectile responses evidenced by an increase of the intracavernous pressure-to-blood pressure ratio. The erectile response was abolished by 1) acute bilateral section of cavernous or pelvic nerves or cauda equina and 2) chronic lesions of pelvic nerves or cauda equina. Acute section of the hypogastric nerve did not significantly decrease the erectile response. The erectile response was significantly depressed after acute or chronic sections of the paravertebral sympathetic chain at the L4-L5 level or chemical sympathectomy with 6-hydroxydopamine. The decrease due to acute sympathetic chain lesion was reversed by bilateral ligation of the external iliac arteries. Accordingly MPOA stimulation elicits erectile responses via 1) activation of the parasympathetic outflow conveyed by the pelvic and cavernous nerves and 2) activation of neural fibers conveyed by the sympathetic pathways. We propose that sympathetic fibers running in the paravertebral sympathetic chain are responsible for vasoconstriction of nonpenile areas to divert blood to the penis, allowing the dramatic increase of penile arterial inflow required for erection.

scholarly journals Optogenetic approaches for the analysis of the role of dopaminergic neurotransmission in the development of alcohol dependence: from correlations to mechanisms

2019 ◽  
pp. 39-40
Author(s):  
E. A. Budygin
Keyword(s):  
Alcohol Drinking ◽  
Dopamine Release ◽  
Drinking Behavior ◽  
Brain Regions ◽  
Alcohol Addiction ◽  
Addictive Behaviors ◽  
Technological Advances ◽  
Dopaminergic Mechanisms ◽  
Neurochemical Changes

Despite many years of work on dopaminergic mechanisms of alcohol addiction, much of this evidence remains mostly correlative in nature. Fortunately, the latest technological advances have provided the opportunity to explore the causal role of neurochemical changes within brain regions involved in addictive behaviors. In this work using optogenetics, we have attempted to answer the question of how dopamine release dynamics control the motivational component of alcohol drinking behavior.

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