Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate

Purpose. To observe ocular surface changes in Type II diabetic patients with different disease durations and to understand the correlations between clinical parameters and diabetic durations. Methods. In this cross-sectional, prospective study, 51 healthy controls and 91 patients with Type II diabetes were enrolled. The diabetics were divided into 3 subgroups according to the disease duration, including duration <10 y group, 10 to 20 y group, and ≥21 y group. All subjects underwent clinical ocular examinations, including lipid layer thickness (LLT), blinking rate, tear meniscus height (TMH), noninvasive tear film break-up time (NI-BUT), meibography, superficial punctate keratopathy (SPK) scoring, corneal sensitivity, and Schirmer I test. They were also evaluated using the standard patient evaluation of eye dryness (SPEED) questionnaire. Results. SPEED score, meiboscore, SPK score, LLT, Schirmer I test, and corneal sensitivity differed significantly between the diabetic and healthy control groups. Further, SPEED score, Schirmer I test, corneal sensitivity, meiboscore, and blink rate significantly differed among the 3 diabetic subgroups and the control group. In diabetics, the SPEED score correlated with the SPK score, blink rate, TMH, and LLT; NI-BUT with TMH, LLT, and blink rate; TMH with the SPK score; Schirmer I test with the SPK score; and corneal sensitivity with the meiboscore. More importantly, the Schirmer I test, corneal sensitivity, and SPEED score negatively correlated with diabetic duration. Conclusion. Diabetic duration is an important factor that affects functions of the lacrimal functional unit in patients with Type II diabetes. The trends of changes in the ocular parameters vary along the course of diabetes.

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Tear Meniscus Dimensions in Tear Dysfunction and Their Correlation With Clinical Parameters

American Journal of Ophthalmology ◽

10.1016/j.ajo.2013.09.024 ◽

2014 ◽

Vol 157 (2) ◽

pp. 301-310.e1 ◽

Cited By ~ 45

Author(s):

Cynthia I. Tung ◽

Andrew F. Perin ◽

Koray Gumus ◽

Stephen C. Pflugfelder

Keyword(s):

Clinical Parameters ◽

Tear Meniscus ◽

Tear Dysfunction

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End-of-day dryness, corneal sensitivity and blink rate in contact lens wearers

Contact Lens and Anterior Eye ◽

10.1016/j.clae.2015.01.003 ◽

2015 ◽

Vol 38 (3) ◽

pp. 148-151 ◽

Cited By ~ 8

Author(s):

Vicente Martín-Montañez ◽

Alberto López-de la Rosa ◽

Alberto López-Miguel ◽

José Pinto-Fraga ◽

José M. González-Méijome ◽

...

Keyword(s):

Contact Lens ◽

Blink Rate ◽

Corneal Sensitivity

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57 Clinical parameters on admission: can they predict in-hospital heart failure after acute coronary syndromes?

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(05)80022-0 ◽

2005 ◽

Vol 4 (1) ◽

pp. 9-9

Keyword(s):

Heart Failure ◽

Acute Coronary Syndromes ◽

Clinical Parameters ◽

Coronary Syndromes

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Staring Down Death

Crisis ◽

10.1027/0227-5910/a000367 ◽

2016 ◽

Vol 37 (3) ◽

pp. 212-217 ◽

Cited By ~ 7

Author(s):

Thomas E. Joiner ◽

Melanie A. Hom ◽

Megan L. Rogers ◽

Carol Chu ◽

Ian H. Stanley ◽

...

Keyword(s):

Suicide Risk ◽

Clinical Utility ◽

Blink Rate ◽

Specific Task ◽

Careful Planning ◽

Eye Blink ◽

Eye Blinks ◽

Potential Clinical Utility ◽

The Relationship

Abstract. Background: Lowered eye blink rate may be a clinically useful indicator of acute, imminent, and severe suicide risk. Diminished eye blink rates are often seen among individuals engaged in heightened concentration on a specific task that requires careful planning and attention. Indeed, overcoming one’s biological instinct for survival through suicide necessitates premeditation and concentration; thus, a diminished eye blink rate may signal imminent suicidality. Aims: This article aims to spur research and clinical inquiry into the role of eye blinks as an indicator of acute suicide risk. Method: Literature relevant to the potential connection between eye blink rate and suicidality was reviewed and synthesized. Results: Anecdotal, cognitive, neurological, and conceptual support for the relationship between decreased blink rate and suicide risk is outlined. Conclusion: Given that eye blinks are a highly observable behavior, the potential clinical utility of using eye blink rate as a marker of suicide risk is immense. Research is warranted to explore the association between eye blink rate and acute suicide risk.

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The Two Components of Social Desirability and their Relations to Resting Frontal Brain Asymmetry

Journal of Individual Differences ◽

10.1027/1614-0001.26.1.29 ◽

2005 ◽

Vol 26 (1) ◽

pp. 29-42 ◽

Cited By ~ 23

Author(s):

Cornelia A. Pauls ◽

Jan Wacker ◽

Nicolas W. Crost

Keyword(s):

Impression Management ◽

Big Five ◽

Hemispheric Asymmetry ◽

Incentive Motivation ◽

Blink Rate ◽

Frontal Brain ◽

Self Reports ◽

Opposite Sex ◽

The Relationship ◽

Α Band

Abstract. The aim of the present study was to investigate the relationships between resting frontal hemispheric asymmetry (FHA) in the low α band (8-10.25 Hz) and the two components of socially desirable responding, i.e., self-deceptive enhancement (SDE) and impression management (IM), in an opposite-sex encounter. In addition, Big Five facets, self-reports of emotion, and spontaneous eye blink rate (BR), a noninvasive indicator of functional dopamine activity, were assessed. SDE as well as IM were related to relatively greater right-than-left activity in the low α band (i.e., relative left frontal activation; LFA) and to self-reported positive affect (PA), but only SDE was related to BR. We hypothesized that two independent types of motivational approach tendencies underlie individual differences in FHA and PA: affiliative motivation represented by IM and agentic incentive motivation represented by SDE. Whereas the relationship between SDE and PA was mediated by BR, the relationship between SDE and FHA was not.

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EMDR Clinical Parameters and Research Findings: "What's New and Useful"

PsycEXTRA Dataset ◽

10.1037/e517322011-180 ◽

2007 ◽

Author(s):

Francine Shapiro

Keyword(s):

Clinical Parameters ◽

Research Findings

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Healing venous ulcers with different modalities of leg compression

Phlebologie ◽

10.1055/s-0037-1622150 ◽

2006 ◽

Vol 35 (05) ◽

pp. 349-355 ◽

Cited By ~ 9

Author(s):

E. O. Brizzio ◽

G. Rossi ◽

A. Chirinos ◽

I. Cantero ◽

G. Idiazabal ◽

...

Keyword(s):

Wound Care ◽

Univariate Analysis ◽

Compression Therapy ◽

Healing Time ◽

Clinical Parameters ◽

Compression Stockings ◽

Local Pressure ◽

Ulcer Size ◽

Venous Ulcers ◽

Unexpected Findings

Summary Background: Compression therapy (CT) is the stronghold of treatment of venous leg ulcers. We evaluated 5 modalities of CT in a prospective open pilot study using a unique trial design. Patients and methods: A group of experienced phlebologists assigned 31 consecutive patients with 35 venous ulcers (present for 2 to 24 months with no prior CT) to 5 different modalities of leg compression, 7 ulcers to each group. The challenge was to match the modality of CT with the features of the ulcer in order to achieve as many healings as possible. Wound care used standard techniques and specifically tailored foam pads to increase local pressure. CT modalities were either stockings Sigvaris® 15-20, 20-30, 30-40 mmHg, multi-layer bandages, or CircAid® bandaging. Compression was maintained day and night in all groups and changed at weekly visits. Study endpoints were time to healing and the clinical parameters predicting the outcome. Results: The cumulative healing rates were 71%, 77%, and 83% after 3, 6, and 9 months, respectively. Univariate analysis of variables associated with nonhealing were: previous surgery, presence of insufficient perforating and/or deep veins, older age, recurrence, amount of oedema, time of presence of CVI and the actual ulcer, and ulcer size (p <0.05-<0.001). The initial ulcer size was the best predictor of the healing-time (Pearson r=0.55, p=0.002). The modality of CT played an important role also, as 19 of 21 ulcers (90%) healed with stockings but only 8 of 14 with bandages (57%; p=0.021). Regression analysis allowed to calculate a model to predict the healing time. It compensated for the fact that patients treated with low or moderate compression stockings were at lower risk of non-healing. and revealed that healing with stockings was about twice as rapid as healing with bandages. Conclusion: Three fourths of venous ulcers can be brought to healing within 3 to 6 months. Healing time can be predicted using easy to assess clinical parameters. Irrespective of the initial presentation ulcer healing appeared more rapid with the application of stockings than with bandaging. These unexpected findings contradict current believes and require confirmation in randomised trials.

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