201: Relationship between maternal characteristics and A-disintegrin and metalloprotease (ADAM12S) in the first trimester

AbstractTo predict gestational diabetes mellitus (GDM) or normoglycemic status using first trimester maternal characteristics.We used data from a prospective cohort study. First trimester maternal characteristics were compared between women with and without GDM. Association of these variables with sugar values at glucose challenge test (GCT) and subsequent GDM was tested to identify key parameters. A predictive algorithm for GDM was developed and receiver operating characteristics (ROC) statistics was used to derive the optimal risk score. We defined normoglycemic state, when GCT and all four sugar values at oral glucose tolerance test, whenever obtained, were normal. Using same statistical approach, we developed an algorithm to predict the normoglycemic state.Maternal age, race, prior GDM, first trimester BMI, and systolic blood pressure (SBP) were all significantly associated with GDM. Age, BMI, and SBP were also associated with GCT values. The logistic regression analysis constructed equation and the calculated risk score yielded sensitivity, specificity, positive predictive value, and negative predictive value of 85%, 62%, 13.8%, and 98.3% for a cut-off value of 0.042, respectively (ROC-AUC – area under the curve 0.819, CI – confidence interval 0.769–0.868). The model constructed for normoglycemia prediction demonstrated lower performance (ROC-AUC 0.707, CI 0.668–0.746).GDM prediction can be achieved during the first trimester encounter by integration of maternal characteristics and basic measurements while normoglycemic status prediction is less effective.

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First trimester maternal characteristics, Doppler parameters and serum analytes after preeclampsia

Hypertension in Pregnancy ◽

10.3109/10641955.2013.853778 ◽

2013 ◽

Vol 33 (2) ◽

pp. 204-214 ◽

Cited By ~ 4

Author(s):

Dana M. Block-Abraham ◽

Ozhan M. Turan ◽

Lauren E. Doyle ◽

Jerome N. Kopelman ◽

Robert O. Atlas ◽

...

Keyword(s):

First Trimester ◽

Maternal Characteristics

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Modified Multiple Marker Aneuploidy Screening as a Primary Screening Test for Preeclampsia

10.21203/rs.3.rs-492997/v1 ◽

2021 ◽

Author(s):

Tianhua Huang ◽

H. Melanie Bedford ◽

Shamim Rashid ◽

Evasha Rasasakaram ◽

Megan Priston ◽

...

Keyword(s):

Preterm Birth ◽

Early Onset ◽

Biochemical Markers ◽

Gestational Hypertension ◽

First Trimester ◽

Second Trimester ◽

Aneuploidy Screening ◽

Maternal Characteristics ◽

Screening Performance ◽

Β Hcg

Abstract Background: Maternal biochemical markers used in multiple marker aneuploidy screening have been associated with adverse pregnancy outcomes. This study aims to assess if a combination of maternal characteristics and biochemical markers in the first and second trimesters can be used to screen for preeclampsia (PE), gestational hypertension and preterm birth. Methods: This case-control study used information on maternal characteristics and residual blood samples from pregnant women who have undergone multiple marker aneuploidy screening. The median multiple of the median (MoM) of first and second trimester biochemical markers in cases (women with PE, gestational hypertension and preterm birth) and controls were compared. Biochemical markers included pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PlGF), human chorionic gonadotropin (hCG), alpha feto-protein (AFP), unconjugated estriol (uE3) and Inhibin A. Logistic regression analysis was used to estimate screening performance using different marker combinations. Screening performance was defined as detection rate (DR) and false positive rate (FPR). Preterm and early-onset preeclampsia PE were defined as women with PE delivered < 37 and < 34 weeks of gestation.Results: There were 147 pregnancies with PE (81 term, 49 preterm and 17 early-onset), 295 with gestational hypertension, and 166 preterm birth. Compared to controls, PE cases had significantly lower median MoM of PAPP-A (0.77 vs 1.10, p<0.0001), PlGF (0.76 vs 1.01, p<0.0001) and free-β hCG (0.81 vs. 0.98, p<0.001) in the first trimester along with PAPP-A (0.82 vs 0.99, p<0.01) and PlGF (0.75 vs 1.02, p<0.0001) in the second trimester. The lowest first trimester PAPP-A, PlGF and free β-hCG were seen in those with preterm and early-onset PE. At a 20% FPR, 67% of preterm and 76% of early-onset PE cases can be predicted using a combination of maternal characteristics with PAPP-A and PlGF in the first trimester.Conclusions: Maternal characteristics with first trimester PAPP-A and PlGF measured for aneuploidy screening provided reasonable accuracy in identifying women at risk of developing early onset PE, allowing triage of high-risk women for further investigation and risk-reducing therapy.

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First-trimester prediction of preterm labor using disintegrin and metalloprotease 12, uterine artery Doppler, and maternal characteristics

Benha Medical Journal ◽

10.4103/bmfj.bmfj_100_18 ◽

2018 ◽

Vol 35 (3) ◽

pp. 356

Author(s):

AymanAbd El Hakim Abd El Ghany ◽

MohamoudEl Sayed Abd Razek

Keyword(s):

Preterm Labor ◽

Uterine Artery ◽

First Trimester ◽

Uterine Artery Doppler ◽

Maternal Characteristics

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Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden

Nutrients ◽

10.3390/nu11071680 ◽

2019 ◽

Vol 11 (7) ◽

pp. 1680 ◽

Cited By ~ 16

Author(s):

Mia Stråvik ◽

Karin Jonsson ◽

Olle Hartvigsson ◽

Anna Sandin ◽

Agnes E. Wold ◽

...

Keyword(s):

Birth Cohort ◽

Observational Studies ◽

Daily Intake ◽

First Trimester ◽

Northern Sweden ◽

Maternal Characteristics ◽

Rural Town ◽

Pregnancy Smoking ◽

Food And Nutrient Intake ◽

High Level

Linkages between diet and other lifestyle factors may confound observational studies. We used cluster analysis to analyze how the intake of food and nutrients during pregnancy co-varies with lifestyle, clinical and demographic factors in 567 women who participated in the NICE (nutritional impact on immunological maturation during childhood in relation to the environment) birth-cohort in northern Sweden. A food frequency questionnaire, Meal-Q, was administered in pregnancy Week 34, and the reported food and nutrient intakes were related to maternal characteristics such as age, education, rural/town residence, parity, pre-pregnancy smoking, first-trimester BMI, allergy and hyperemesis. Two lifestyle-diet clusters were identified: (1) High level of education and higher age were related to one another, and associated with a diet rich in fruits, vegetables, whole grains and fish, and (2) smoking before pregnancy and higher BMI in early pregnancy were related to one another and associated with a diet that contained white bread, French fries, pizza, meat, soft drinks, candy and snacks. More than half of the women had lower-than-recommended daily intake levels of vitamin D, folate, selenium, and iodine. Complex lifestyle-diet interactions should be considered in observational studies that link diet and pregnancy outcome.

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Low Prevalence of Folic Acid Supplementation during Pregnancy: A Multicenter Study in Vietnam

Nutrients ◽

10.3390/nu11102347 ◽

2019 ◽

Vol 11 (10) ◽

pp. 2347 ◽

Cited By ~ 1

Author(s):

Ha ◽

Zhao ◽

Binns ◽

Pham ◽

Nguyen ◽

...

Keyword(s):

Folic Acid ◽

Neural Tube ◽

Multicenter Study ◽

First Trimester ◽

Folic Acid Supplementation ◽

Antenatal Visit ◽

Maternal Characteristics ◽

Supplement Use ◽

Education Levels ◽

Formal Employment

Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube defects (NTDs), but little information is known about its use in Vietnam. It is important that FA supplements start to be taken when planning a pregnancy and continued through the first trimester to prevent NTDs, as the neural tube closes in the first month of pregnancy. However, FA supplementation in Vietnam is usually recommended to commence from the first antenatal visit, which is usually at 16 weeks, and very few women take FA before their first visit. This multicenter study aimed to determine the prevalence of FA supplement use and associated maternal characteristics in Vietnam. FA supplementation was assessed in 2030 singleton pregnant women between 2015 and 2016. In total, 654 (32.2%) women reported taking either supplements containing FA alone or multivitamins containing FA, and 505 (24.9%) reported correctly taking supplements containing FA alone. Women who were aged 30 years or over, had low education levels, had formal employment, and whose current pregnancy was first or unplanned were less likely to supplement with FA. Education programs are needed to encourage FA supplementation when contemplating pregnancy.

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First trimester prediction of small- and large-for-gestation neonates by an integrated model incorporating ultrasound parameters, biochemical indices and maternal characteristics

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1111/j.1600-0412.2011.01271.x ◽

2011 ◽

Vol 91 (1) ◽

pp. 104-111 ◽

Cited By ~ 28

Author(s):

IOANNIS PAPASTEFANOU ◽

ATHENA P. SOUKA ◽

ATHANASIOS PILALIS ◽

MAKARIOS ELEFTHERIADES ◽

VASILIKI MICHALITSI ◽

...

Keyword(s):

First Trimester ◽

Integrated Model ◽

Maternal Characteristics ◽

Biochemical Indices ◽

Ultrasound Parameters

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OC04.03: Screening for pre-eclampsia in the first trimester based on maternal characteristics, biophysical parameters and angiogenic factors

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.13484 ◽

2014 ◽

Vol 44 (S1) ◽

pp. 8-8

Author(s):

F. Crovetto ◽

F. Figueras ◽

S. Triunfo ◽

F. Crispi ◽

V. Rodriguez-Sureda ◽

...

Keyword(s):

First Trimester ◽

Angiogenic Factors ◽

Biophysical Parameters ◽

Maternal Characteristics

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Incidence of congenital toxoplasmosis in southern Brazil: a prospective study

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652003000300006 ◽

2003 ◽

Vol 45 (3) ◽

pp. 147-151 ◽

Cited By ~ 18

Author(s):

Liége Mozzatto ◽

Renato Soibelmann Procianoy

Keyword(s):

Toxoplasma Gondii ◽

Gestational Age ◽

Newborn Infants ◽

Congenital Toxoplasmosis ◽

Congenital Infection ◽

First Trimester ◽

Laboratory Diagnosis ◽

Anthropometric Measures ◽

Maternal Characteristics ◽

The Town

The study aimed to determine the incidence of congenital infection by Toxoplasma gondii and to describe neonatal and maternal characteristics regarding newborn infants treated at a teaching hospital in the town of Passo Fundo, State of Rio Grande do Sul, Brazil. Cord blood samples collected from 1,250 live newborns were analyzed. The laboratory diagnosis was established by the detection of Toxoplasma gondii IgM using an enzyme linked fluorescent assay. Gestational age, intrauterine growth, anthropometric measures, and prenatal characteristics were assessed. The incidence of congenital toxoplasmosis at birth was 8/10,000 (95%CI 0.2-44.5). Mean birthweight was 3,080 ± 215.56 grams and mean gestational age was 38.43 ± 1.88 weeks. With regard to prenatal care, 58% of the pregnant patients visited their doctors five times or more and 38.9% were serologically tested for toxoplasmosis in the first trimester of pregnancy. The incidence of congenital toxoplasmosis was similar to that found in most studies conducted in our country and abroad. Our study sample is representative of the town of Passo Fundo and therefore it is possible to consider the frequency observed as the prevalence of the disease in this town during the study period.

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