720: Long term health after in utero exposure to the Geneva Steel Mill closure

AbstractLittle is known about the long-term neurological development of children diagnosed with congenital Zika infection at birth. Here, we report the imaging and clinical outcomes up to three years of life of a cohort of 129 children exposed to Zika virus in utero. Eighteen of them (14%) had a laboratory confirmed congenital Zika infection at birth. Infected neonates have a higher risk of adverse neonatal and early infantile outcomes (death, structural brain anomalies or neurologic symptoms) than those who tested negative: 8/18 (44%) vs 4/111 (4%), aRR 10.1 [3.5–29.0]. Neurological impairment, neurosensory alterations or delays in motor acquisition are more common in infants with a congenital Zika infection at birth: 6/15 (40%) vs 5/96 (5%), aRR 6.7 [2.2–20.0]. Finally, infected children also have an increased risk of subspecialty referral for suspected neurodevelopmental delay by three years of life: 7/11 (64%) vs 7/51 (14%), aRR 4.4 [1.9–10.1]. Infected infants without structural brain anomalies also appear to have an increased risk, although to a lesser extent, of neurological abnormalities. It seems paramount to offer systematic testing for congenital ZIKV infection in cases of in utero exposure and adapt counseling based on these results.

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AB0423 NEUROPSYCHIATRIC OUTCOME OF CHILDREN BORN TO WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) WOMEN AND EXPOSED IN UTERO TO AZATHIOPRINE: A CASE-CONTROL STUDY.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4912 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1511.2-1511

Author(s):

M. G. Lazzaroni ◽

F. Crisafulli ◽

I. Debeni ◽

C. Nalli ◽

L. Andreoli ◽

...

Keyword(s):

Lupus Erythematosus ◽

Renal Involvement ◽

In Utero ◽

Learning Disorders ◽

Control Group ◽

In Utero Exposure ◽

Term Outcome ◽

Similar Frequency ◽

Long Term Outcome

Background:A possible increase in neurodevelopmental (ND) and learning disorders (LD) in the offspring of mothers affected by SLE have been suggested in some studies, along with the identification of different possible risk factors. Azathioprine (AZA) is commonly used during pregnancy, based on its non-teratogenicity and extended experience in women with different diseases. However, a few small studies suggested an association between in utero exposure to AZA and possible increased frequency of ND/LD in children, indirectly derived from increased request of supportive educational services.Objectives:To evaluate the medium-long term outcome in terms of ND/LD in children of school age (≥6 years) born to SLE women treated with AZA during pregnancy, as compared to that of children born to SLE mothers not treated with AZA during pregnancy.Methods:Data from our Pregnancy Clinic registry were collected for prospectively followed pregnancies of SLE women treated with AZA (cases) and compared to pregnancies of SLE women not treated with AZA (controls), that were matched for age at pregnancy, presence of renal involvement and aPL positivity. SLE patients (cases and controls) were interviewed by phone to collect data about their children, focusing on the presence of ND/LD certified by Neuropsychiatrists.Results:Data were collected for 14 SLE mothers in the AZA group and 31 in the control group, with similar age at pregnancy (30.3±5.21 vs 31.4±4.70 years, p:0.45) and frequency of renal involvement (50.0% vs 44.1%, p:0.77), aPL positivity (33.3% vs 29.4%, p:0.76) and anti-Ro/SSA positivity (27.8% vs. 26.5%, p:0.55). A SLE flare during pregnancy was more frequently recorded in the AZA group (27.8% vs. 2.94%, p:0.02). Other medications included HCQ (55.6% vs. 70.6%, p:0.36) and corticosteroids (100% vs 79.4%, p:0.08).We collected data for 18 children in the AZA group and 34 children in the control group, that had a similar mean age at the time of the interview (12.7±4.80 vs. 12.9±5.61 years, p:0.91). The two groups had also similar gestational age (37.4±2.20 weeks vs. 38.0±1.29 weeks, p:0.23), birth weight (3003±433 g vs 3011±453 g, p:0.95) and rate of male sex (61.1% vs 44.1%, p:0.38).We recorded similar frequency of ND/LD in the two groups. In particular, a ND was present in 2/18 (11.1%) of children exposed to AZA vs. 2/34 (5.88%) in the control group (p:0.60). A LD was present in 1/18 cases (5.56%) and 6/34 controls (17.6%) (p:0.40).Conclusion:The medium-long term outcome of children born to SLE mothers in the whole cohort was characterized by the presence of ND in 4/54 (7.69%) and LD in 7/52 (13.5%). ND/LD do not seem to be related to in utero exposure to AZA.Disclosure of Interests:None declared

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LONG TERM EFFECTS OF IN-UTERO EXPOSURE TO PERFLUORINATED CHEMICALS ON FEMALE REPRODUCTION

ISEE Conference Abstracts ◽

10.1289/isee.2011.00638 ◽

2011 ◽

Vol 2011 (1) ◽

Author(s):

Susanne Lund Kristensen ◽

Cecilia Høst Ramlau-Hansen ◽

Erik Ernst ◽

Sjurdur Frodi Olsen ◽

Jens Peter Bonde ◽

...

Keyword(s):

In Utero ◽

In Utero Exposure ◽

Long Term Effects ◽

Female Reproduction ◽

Perfluorinated Chemicals

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In-Utero Exposure to Cigarette Smoking on Child Long-Term Risk of Obesity: Concordance of Self-Report, Maternal and Cord Blood Biomarkers

10.20944/preprints202110.0296.v1 ◽

2021 ◽

Author(s):

Wenpin Hou ◽

Mingyu Zhang ◽

Yuelong Ji ◽

Xiumei Hong ◽

Guoying Wang ◽

...

Keyword(s):

Cigarette Smoking ◽

In Utero ◽

Self Report ◽

In Utero Exposure ◽

Cord Plasma ◽

Smoking Exposure ◽

Increased Risk ◽

Logistic Regressions ◽

Reported Data

Most studies on the association of in utero exposure to cigarette smoking and childhood overweight or obesity (OWO) were based on maternal self-reported smoking data and few were based on objective biomarkers. In this study, we evaluated the associations between self-reported and biomarkers of in utero exposure to cigarette smoking with risk of childhood OWO. We analyzed data from 2351 mother-child pairs in the Boston Birth Cohort, a US low-income minority cohort that enrolled children at birth and followed prospectively up to age 18 years. In utero smoking exposure was measured by maternal self-report and by maternal and cord plasma cotinine and hydroxycotinine metabolites. We assessed the individual and joint associations of each smoking exposure measure and maternal OWO with childhood OWO using multinomial logistic regressions. We used nested logistic regressions to investigate the childhood OWO prediction performance when adding maternal and cord plasma biomarkers as input covariates on top of self-reported data. Our results demonstrated that in utero cigarette smoking exposure defined by self-report and by maternal or cord metabolites were consistently associated with increased risk of long-term child OWO. Adding maternal and cord plasma biomarker information to self-reported data improved the prediction accuracy of long-term child OWO risk.

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Long-term Effects of In Utero Exposure to “The Year without a Summer”

Economic and Business Review ◽

10.15458/2335-4216.1288 ◽

2021 ◽

Vol 23 (3) ◽

Author(s):

Hamid Noghanibehambari ◽

Farzaneh Noghani ◽

Nahid Tavassoli ◽

Mostafa Toranji

Keyword(s):

In Utero ◽

In Utero Exposure ◽

Long Term Effects

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Long-Term Neurodevelopmental Outcome of Children after in Utero Exposure to Chemotherapy

Cancers ◽

10.3390/cancers12123623 ◽

2020 ◽

Vol 12 (12) ◽

pp. 3623

Author(s):

Anna-Maria Korakiti ◽

Eleni Zografos ◽

Mathilde van Gerwen ◽

Frédéric Amant ◽

Meletios-Athanasios Dimopoulos ◽

...

Keyword(s):

Large Scale ◽

Infant Development ◽

Neurodevelopmental Outcome ◽

Fetal Brain ◽

In Utero ◽

Chemotherapeutic Agents ◽

In Utero Exposure ◽

Cancer Management ◽

Anti Cancer

Pregnancy-related cancer management represents a real challenge for both the patients and the physicians. The long-term neurodevelopmental outcome of children in utero exposed to chemotherapeutic agents has only recently been addressed. This review aims to systematically integrate and highlight all existing data from the literature regarding the effect of prenatal exposure to chemotherapy on fetal brain growth and child development. All eligible studies are based on validated neurodevelopmental testing scales (e.g., Bayley Scales of Infant Development, Wechsler Preschool and Primary Scale of Intelligence) and/or well-defined questionnaires. Our systematic review including 17 studies demonstrates that no major consequences on the neurodevelopment of children after in utero exposure to anti-cancer drugs have been reported; nevertheless, longer and more thorough follow-up with large-scale multicenter prospective studies is certainly required in order to draw firm conclusions.

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