scholarly journals Balancing risks: making decisions for maternal treatment without data on fetal safety

2021 ◽  
Author(s):  
Howard Minkoff ◽  
Jeffrey Ecker
Keyword(s):  
Maternal Treatment ◽  
Fetal Safety

scholarly journals Antibiotic Prescriptions among China Ambulatory Care Visits of Pregnant Women: A Nationwide Cross-Sectional Study

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 601
Author(s):  
Houyu Zhao ◽  
Mei Zhang ◽  
Jiaming Bian ◽  
Siyan Zhan
Keyword(s):  
Pregnant Women ◽  
Ambulatory Care ◽  
National Level ◽  
Mainland China ◽  
Antibiotic Use ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Fetal Safety ◽  
First Trimester Of Pregnancy

Background: Antibiotic use in pregnant women at the national level has rarely been reported in China. Objectives: We aimed to investigate antibiotic prescriptions during pregnancy in ambulatory care settings in China. Methods: Data of 4,574,961 ambulatory care visits of pregnant women from October 2014 to April 2018 were analyzed. Percentages of Antibiotic prescriptions by different subgroups and various diagnosis categories and proportions of inappropriate antibiotic prescriptions for different subgroups were estimated. Food and Drug Administration (FDA) pregnancy categories were used to describe the antibiotic prescription patterns. The 95% confidence intervals (CIs) were estimated using the Clopper––Pearson method or Goodman method. Results: Among the 4,574,961 outpatient visits during pregnancy, 2.0% (92,514 visits; 95% CI, 2.0–2.0%) were prescribed at least one antibiotic. The percentage of antibiotic prescriptions for pregnant women aged >40 years was 4.9% (95% CI, 4.7–5.0%), whereas that for pregnant women aged 26–30 years was 1.5% (95% CI, 1.4–1.5%). In addition, percentages of antibiotic prescriptions varied among different trimesters of pregnancy, which were 5.4% (95% CI, 5.3–5.4%) for the visits in the first trimester of pregnancy and 0.5% (95% CI, 0.4–0.5%) in the third trimester of pregnancy. Furthermore, the percentages of antibiotic prescriptions substantially varied among different diagnosis categories and nearly three-quarters of antibiotic prescriptions had no clear indications and thus might be inappropriate. In total, 130,308 individual antibiotics were prescribed; among these, 60.4% (95% CI, 60.0–60.8%) belonged to FDA category B, 2.7% (95% CI, 2.1–3.5%) were classified as FDA category D and 16.8% (95% CI, 16.2–17.4%) were not assigned any FDA pregnancy category. Conclusions: Antibiotic prescriptions in ambulatory care during pregnancy were not highly prevalent in mainland China. However, a substantial proportion of antibiotics might have been prescribed without adequate indications. Antibiotics whose fetal safety has not been sufficiently illustrated were widely used in pregnant women.

Maternal treatment with picrotoxin in late pregnancy improved female sexual behavior but did not alter male sexual behavior of offspring

2013 ◽  
Vol 24 (4) ◽  
pp. 282-290 ◽  
Author(s):  
Maria M. Bernardi ◽  
Kayne K. Scanzerla ◽  
Mayra Chamlian ◽  
Elizabeth Teodorov ◽  
Luciano F. Felicio
Keyword(s):  
Sexual Behavior ◽  
Late Pregnancy ◽  
Female Sexual Behavior ◽  
Male Sexual Behavior ◽  
Maternal Treatment

Fetal safety of loratadine use in the first trimester of pregnancy: A multicenter study

2003 ◽  
Vol 111 (3) ◽  
pp. 479-483 ◽  
Author(s):  
Myla E. Moretti ◽  
Daniela Caprara ◽  
Christopher J. Coutinho ◽  
Benjamin Bar-Oz ◽  
Mati Berkovitch ◽  
...  
Keyword(s):  
Multicenter Study ◽  
First Trimester ◽  
Fetal Safety ◽  
First Trimester Of Pregnancy

Maternal depression and maternal treatment of siblings as predictors of child psychopathology.

1995 ◽  
Vol 31 (3) ◽  
pp. 395-405 ◽  
Author(s):  
Louisa B. Tarullo ◽  
Elizabeth K. DeMulder ◽  
Donna S. Ronsaville ◽  
Eurnestine Brown ◽  
Marian Radke-Yarrow
Keyword(s):  
Maternal Depression ◽  
Child Psychopathology ◽  
Maternal Treatment

Maternal treatment with fluoxetine promotes testicular alteration in male rat pups

2016 ◽  
Vol 28 (8) ◽  
pp. 1206 ◽  
Author(s):  
Aline C. Ramos ◽  
Alice H. dos Santos ◽  
Kennia M. Silveira ◽  
Ana Carolina I. Kiss ◽  
Suzana F. P. Mesquita ◽  
...  
Keyword(s):  
Tap Water ◽  
Post Partum ◽  
Gonadosomatic Index ◽  
Male Offspring ◽  
Male Rat ◽  
Control Group ◽  
Maternal Behaviour ◽  
Testis Weight ◽  
Water Control ◽  
Maternal Treatment

Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRI) antidepressant commonly prescribed during pregnancy and lactation. Pre- and post-partum depression, as well as SSRI treatment during these periods, may change maternal care, interfering with offspring development. Moreover, it is known that SSRIs may alter testes structure and function in offspring. The present study investigated the effects of maternal FLX exposure on maternal behaviour and testes function in offspring. Female Wistar rats were treated with 7.5 mg kg–1 FLX or tap water (control group) by gavage from the Day 1 of pregnancy until 21 days after birth (postnatal Day (PND) 21). Maternal behaviour was evaluated and morphofunctional analyses of offspring testes were conducted on PND 21 and 50. There were no significant differences between the FLX-treated and control groups regarding maternal behaviour. Nor did maternal treatment with FLX have any effect on bodyweight gain, anogenital distance, day of preputial separation, testis weight and the gonadosomatic index in male offspring. However, there was a decreased number of Sertoli cells at both PND 21 and 50 in FLX-exposed male offspring. The findings of the present study demonstrate that maternal exposure to FLX can impair testicular function in weanling and pubertal animals.

Fetal safety profile of aromatase inhibitors: Animal data

2016 ◽  
Vol 66 ◽  
pp. 84-92
Author(s):  
Gian Mario Tiboni ◽  
Adalisa Ponzano
Keyword(s):  
Aromatase Inhibitors ◽  
Safety Profile ◽  
Animal Data ◽  
Fetal Safety

scholarly journals Applying the Newman-Peacock Prognostic System to a Portuguese Obstetrical Population - A Useful Tool?

2017 ◽  
Vol 40 (01) ◽  
pp. 004-010
Author(s):  
Rita Mendes Silva ◽  
Nuno Clode
Keyword(s):  
Operating Characteristic ◽  
Univariate Analysis ◽  
Original Study ◽  
External Cephalic Version ◽  
North American Population ◽  
Amniotic Fluid Index ◽  
Prognostic System ◽  
Prognostic Groups ◽  
Chi Squared ◽  
Fetal Safety

Background External cephalic version (ECV) is a maneuver that enables the rotation of the non-cephalic fetus to a cephalic presentation. The Newman-Peacock (NP) index, which was proposed by Newman et al. in a study published in 1993, was described as a prediction tool of the success of this procedure; it was validated in a North-American population, and three prognostic groups were identified. Purpose To evaluate the value of the NP score for the prediction of a successful ECV in a Portuguese obstetrical population, and to evaluate maternal and fetal safety. Methods We present an observational study conducted from 1997–2016 with pregnant women at 36–38 weeks of pregnancy who were candidates for external cephalic version in our department. Demographic and obstetrical data were collected, including the parameters included in the NP index (parity, cervical dilatation, estimated fetal weight, placental location and fetal station). The calculation of the NP score was performed, and the percentages of success were compared among the three prognostic groups and with the original study by Newman et al. The performance of the score was determined using the Student t-test, the Chi-squared test, and a receiver operating characteristic (ROC) curve. Results In total, 337 women were included. The overall success rate was of 43.6%. The univariate analysis revealed that multiparity, posterior placentation and a less engaged fetus were factors that favored a successful maneuver (p < 0.05). Moreover, a higher amniotic fluid index was also a relevant predictive factor (p < 0.05). The Newman-Peacock score had a poorer performance in our population compared with that of the sample of the original study, but we still found a positive relationship between higher scores and higher prediction of success (p < 0.001). No fetal or maternal morbidities were registered. Conclusions The Newman-Peacock score had a poorer performance among our population compared to its performance in the original study, but the results suggest that this score is still a useful tool to guide our clinical practice and counsel the candidate regarding ECV.

scholarly journals Canadian Association of Radiologists Recommendations for the Safe Use of MRI During Pregnancy

2021 ◽  
pp. 084653712110156
Author(s):  
Pejman Jabehdar Maralani ◽  
Anish Kapadia ◽  
Grace Liu ◽  
Felipe Moretti ◽  
Hournaz Ghandehari ◽  
...  
Keyword(s):  
Working Group ◽  
Energy Deposition ◽  
Expert Panel ◽  
Acoustic Noise ◽  
Evidence Based ◽  
Resonance Imaging ◽  
Canadian Association ◽  
Fetal Safety ◽  
Magnetic Resonance Imaging Mri ◽  
In Pregnancy

The use of magnetic resonance imaging (MRI) during pregnancy is associated with concerns among patients and health professionals with regards to fetal safety. In this work, the Canadian Association of Radiologists (CAR) Working Group on MRI in Pregnancy presents recommendations for the use of MRI in pregnancy, derived from literature review as well as expert panel opinions and discussions. The working group, which consists of academic subspecialty radiologists and obstetrician-gynaecologists, aimed to provide updated, evidence-based recommendations addressing safety domains related to energy deposition, acoustic noise, and gadolinium-based contrast agent use based on magnetic field strength (1.5T and 3T) and trimester scanned, in addition to the effects of sedative use and occupational exposure.

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