Chorioamnionitis grade correlates with myometrial leukocyte infiltration and pro-labor progesterone receptor modification

Emily K. Redman; Jessica Thorpe; David N. Hackney; Raymond W. Redline; Rachel A. Wilson; Pietro Presicce; Suhas G. Kallapur; Sam A. Mesiano

doi:10.1016/j.ajog.2021.11.836

Chorioamnionitis grade correlates with myometrial leukocyte infiltration and pro-labor progesterone receptor modification

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2021.11.836 ◽

2022 ◽

Vol 226 (1) ◽

pp. S507

Author(s):

Emily K. Redman ◽

Jessica Thorpe ◽

David N. Hackney ◽

Raymond W. Redline ◽

Rachel A. Wilson ◽

...

Keyword(s):

Progesterone Receptor ◽

Leukocyte Infiltration

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Distribution of estrogen receptor alpha and progesterone receptor, and leukocyte infiltration in the cervix of cyclic bitches and those with pyometra

Theriogenology ◽

10.1016/j.theriogenology.2010.11.004 ◽

2011 ◽

Vol 75 (6) ◽

pp. 979-987 ◽

Cited By ~ 6

Author(s):

Panisara Kunkitti ◽

Sayamon Srisuwatanasagul ◽

Kaywalee Chatdarong

Keyword(s):

Estrogen Receptor ◽

Progesterone Receptor ◽

Estrogen Receptor Alpha ◽

Leukocyte Infiltration ◽

Receptor Alpha

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Estrogen receptor α and progesterone receptor A and B concentration and localization in the lower uterine segment in term parturition

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(02)00156-9 ◽

2002 ◽

Vol 9 (4) ◽

pp. 226-232 ◽

Cited By ~ 9

Author(s):

M Winkler

Keyword(s):

Estrogen Receptor ◽

Progesterone Receptor ◽

Estrogen Receptor Α ◽

Lower Uterine Segment

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Progesterone receptor localization and isoforms in myometrium, decidua, and fetal membranes from rhesus macaques: evidence for functional progesterone withdrawal at parturition

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(02)00144-2 ◽

2002 ◽

Vol 9 (3) ◽

pp. 125-136 ◽

Cited By ~ 49

Author(s):

G Haluska

Keyword(s):

Progesterone Receptor ◽

Rhesus Macaques ◽

Fetal Membranes ◽

Receptor Localization

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Up-Regulation of the Progesterone Receptor (PR)-C Isoform in Laboring Myometrium by Activation of Nuclear Factor-κB May Contribute to the Onset of Labor through Inhibition of PR Function

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70016-x ◽

2007 ◽

Vol 2007 ◽

pp. 20

Author(s):

S.E. Bulun

Keyword(s):

Progesterone Receptor ◽

Nuclear Factor Κb ◽

Nuclear Factor

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Pharmacokinetics and safety of tanaproget, a nonsteroidal progesterone receptor agonist, in healthy women

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70162-0 ◽

2007 ◽

Vol 2007 ◽

pp. 228-229

Author(s):

L.P. Shulman

Keyword(s):

Progesterone Receptor ◽

Receptor Agonist ◽

Healthy Women

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3552 Dose-dependent anti-inflammatory effects of rosuvastatin: prevention of leukocyte infiltration, iNOS induction and collagen expression in angiotensin II-induced nephrosclerosis

European Heart Journal ◽

10.1016/s0195-668x(03)96150-1 ◽

2003 ◽

Vol 24 (5) ◽

pp. 690 ◽

Cited By ~ 1

Author(s):

J PARK

Keyword(s):

Angiotensin Ii ◽

Leukocyte Infiltration ◽

Collagen Expression ◽

Anti Inflammatory ◽

Dose Dependent ◽

Inos Induction

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Progesterone receptor membrane component-1 promotes cancer cell proliferation and resistance to anthracycline treatment in breast cancer

Senologie - Zeitschrift für Mammadiagnostik und -therapie ◽

10.1055/s-0037-1602575 ◽

2017 ◽

Vol 14 (02) ◽

pp. A1-A53

Author(s):

M Willibald ◽

I Wurster ◽

G Bayer ◽

H Seeger ◽

AO Mueck ◽

...

Keyword(s):

Breast Cancer ◽

Cell Proliferation ◽

Progesterone Receptor ◽

Cancer Cell ◽

Cancer Cell Proliferation ◽

Membrane Component ◽

Receptor Membrane

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Upon Progestin Stimulation Progesterone Receptor Membrane Component-1 is Phosphorylated in Breast Cancer Cells and Binds to Estrogen Receptor α-Coregulators PHB1 and PHB2

10.1055/s-0037-1606151 ◽

2017 ◽

Author(s):

M Willibald ◽

G Bayer ◽

V Stahlhut ◽

G Poschmann ◽

K Stühler ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Progesterone Receptor ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Estrogen Receptor Α ◽

Membrane Component ◽

Receptor Membrane

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Diffusion profiling via a whole tumor histogram approach distinguishes low-grade from high-grade meningiomas, can reflect the respective proliferative potential and indicates progesterone receptor status

10.1055/s-0038-1641416 ◽

2018 ◽

Cited By ~ 1

Author(s):

G Gihr

Keyword(s):

Progesterone Receptor ◽

Proliferative Potential ◽

Low Grade ◽

High Grade ◽

Progesterone Receptor Status ◽

Receptor Status

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Inhibition of TMEM16A impedes embryo implantation and decidualization in mice

Reproduction ◽

10.1530/rep-18-0197 ◽

2018 ◽

Cited By ~ 2

Author(s):

Qianrong Qi ◽

Yifan Yang ◽

Kailin Wu ◽

Qingzhen Xie

Keyword(s):

Progesterone Receptor ◽

Stromal Cells ◽

Embryo Implantation ◽

Mouse Uterus ◽

Endometrial Stromal Cells ◽

Uterine Endometrium ◽

Molecule Inhibitor ◽

Pathway Inhibition ◽

And Function ◽

Reproductive Processes

Recent studies revealed that TMEM16A is involved in several reproductive processes, including ovarian estrogen secretion and ovulation, sperm motility and acrosome reaction, fertilization, and myometrium contraction. However, little is known about the expression and function of TMEM16A in embryo implantation and decidualization. In this study, we focused on the expression and regulation of TMEM16A in mouse uterus during early pregnancy. We found that TMEM16A is up-regulated in uterine endometrium in response to embryo implantation and decidualization. Progesterone treatment could induce TMEM16A expression in endometrial stromal cells through progesterone receptor/c-Myc pathway, which is blocked by progesterone receptor antagonist or the inhibitor of c-Myc signaling pathway. Inhibition of TMEM16A by small molecule inhibitor (T16Ainh-A01) resulted in impaired embryo implantation and decidualization in mice. Treatment with either specific siRNA of Tmem16a or T16Ainh-A01 inhibited the decidualization and proliferation of mouse endometrial stromal cells. In conclusion, our results revealed that TMEM16A is involved in embryo implantation and decidualization in mice, compromised function of TMEM16A may lead to impaired embryo implantation and decidualization.

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