Factors Associated With Presence and Extent of Coronary Calcium in Those Predicted to Be at Low Risk According to Framingham Risk Score (from the Multi-Ethnic Study of Atherosclerosis)

Abstract: Atherosclerotic cardiovascular disease is caused by the accumulation of plaque on the artery wall causing dysfunction of anatomical and hemodynamic system of the heart and blood flow. There are many risk factors that cause atherosclerotic cardiovascular disease which are divided into modifiable and unmodifiable risk factors. Prevention of this disease can be achieved with early detection, such as prediction the risk level of 10 years ahead of atherosclerotic cardiovascular disease by using the Framingham Risk Score (FRS). This study was aimed to obtain the risk level of atherosclerotic cardiovascular disease in patients at Internal Medicine Polyclinic of Prof. Dr. R. D. Kandou Hospital Manado by using their medical records from September to October 2017. This was a descriptive study with a cross sectional design. There were 100 samples obtained by using conclusive sampling technique. Of the 100 patients, 42 (42%) patients had low risk, 27 (27%) patients had moderate risk, and 31 (31%) patients had high risk of atherosclerotic cardiovascular disease in 10 years ahead. Conclusion: In this study, the highest percentage was in patients with low risk, followed by patients with high risk, and moderate risk.Keywords: ASCVD, Framingham Risk Score, Risk of atherosclerotic cardiovascular sisease. Abstrak: Penyakit kardiovaskuler aterosklerotik adalah penyakit yang disebabkan oleh adanya timbunan plak pada dinding arteri sehingga menyebabkan gangguan fungsional, anatomis serta sistem hemodinamis jantung dan pembuluh darah. Terdapat banyak faktor risiko yang menyebabkan terjadinya penyakit kardiovaskuler aterosklerotik yang dibagi menjadi faktor risiko yang dapat dimodifikasi dan yang tidak dapat dimodifikasi. Pencegahan penyakit ini dapat dilakukan dengan deteksi dini, salah satunya yaitu dengan memrediksi tingkat risiko 10 tahun kedepan terjadinya penyakit kardiovaskuler aterosklerotik dengan menggunakan Framingham Risk Score. Penelitian ini bertujuan untuk mengetahui tingkat risiko penyakit kardiovaskuler ateroskerotik pada pasien di Poliklinik Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang menggunakan data rekam medik pasien Poliklinik Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado periode September - Oktober 2017. Sampel penelitian berjumlah 100 orang dengan teknik pengambilan conclusive sampling. Terdapat 42 pasien (42%) dengan tingkat risiko rendah, 27 pasien (27%) dengan risiko sedang, dan 31 pasien (31%) dengan risiko tinggi terkena penyakit kardiovaskuler aterosklerotik 10 tahun kedepan. Simpulan: Pada studi ini, persentase tertinggi ialah pasien dengan tingkat risiko rendah terjadinya penyakit kardiovaskuler aterosklerotik, diikuti tingkat risiko tinggi dan risiko sedang.Kata kunci: ASCVD, Framingham Risk Score, tingkat risiko penyakit kardiovaskuler aterosklerotik

Download Full-text

Cis-vaccenic acid and the Framingham risk score predict chronic kidney disease: The multi-ethnic study of atherosclerosis (MESA)

Prostaglandins Leukotrienes and Essential Fatty Acids ◽

10.1016/j.plefa.2012.02.009 ◽

2012 ◽

Vol 86 (4-5) ◽

pp. 175-182 ◽

Cited By ~ 12

Author(s):

Robert Block ◽

Lisa Kakinami ◽

Scott Liebman ◽

Gregory C. Shearer ◽

Holly Kramer ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Risk Score ◽

Framingham Risk Score ◽

Vaccenic Acid ◽

Ethnic Study ◽

Framingham Risk

Download Full-text

Predicting the 10-year risk of cardiovascular diseases and its relation to healthy diet indicator in Iranian military personnel

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02231-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Karim Parastouei ◽

Mojtaba Sepandi ◽

Eslam Eskandari

Keyword(s):

Risk Score ◽

Military Personnel ◽

Framingham Risk Score ◽

Lifestyle Modification ◽

Sodium Intake ◽

Low Risk ◽

Healthy Diet ◽

Dietary Sodium ◽

Framingham Risk ◽

The Mean

Abstract Background Epidemiological studies indicate increased prevalence of cardiovascular disease (CVD) among military personnel. Accordingly, identification of at-risk individuals and lifestyle modification such as improving diet quality can potentially inhibits the increasing trend of CVD mortality. The aim of this study was predicting the 10-year risk of CVD and its association with healthy diet indicator (HDI) among military personnel. Methods In this cross-sectional study, 400 male military personnel within the age range of 30–75 years were included. HDI score was calculated based on food frequency questionnaire, and the 10-year risk of CVD was evaluated using Framingham risk score (FRS). The FRS items include age, gender, total cholesterol, high density lipoprotein cholesterol (HDL-C), systolic blood pressure, status of diabetes and smoking. Partial correlation test was employed to investigate the relationship between Framingham risk score and HDI score. Results The mean age and body mass index (BMI) of participants were 38.67 ± 5.3 year and 25.28 ± 3.22 kg/m2, respectively. Prediction of FRS was as follows: 96.5% were low risk, 2% were moderate risk, and 1.5% were high risk. The mean HDI score of participants in this study was 5.98 ± 1.36. While HDI score did not show a significant correlation with FRS (r: − 0.009, p:0.860), increased dietary sodium intake had a significant positive correlation with FRS (r: 0.114, p:0.026). Conclusion The most of participants (96.5%) had in low risk of CVD development in the next 10 years. Meanwhile, the FRS showed no significant relationship with HDI score. Further researches are required to confirm the results of the present study.

Download Full-text

A Comparison of Assessment of Coronary Calcium vs Carotid Intima Media Thickness for Determination of Vascular Age and Adjustment of the Framingham Risk Score

Preventive Cardiology ◽

10.1111/j.1751-7141.2010.00071.x ◽

2010 ◽

Author(s):

Yasser Khalil ◽

Bertrand Mukete ◽

Michael J Durkin ◽

June Coccia ◽

Martin E. Matsumura

Keyword(s):

Risk Score ◽

Framingham Risk Score ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Coronary Calcium ◽

Media Thickness ◽

Framingham Risk ◽

Vascular Age

Download Full-text

Activated TLR Signaling in Atherosclerosis among Women with Lower Framingham Risk Score: The Multi-Ethnic Study of Atherosclerosis

PLoS ONE ◽

10.1371/journal.pone.0021067 ◽

2011 ◽

Vol 6 (6) ◽

pp. e21067 ◽

Cited By ~ 10

Author(s):

Chiang-Ching Huang ◽

Kiang Liu ◽

Richard M. Pope ◽

Pan Du ◽

Simon Lin ◽

...

Keyword(s):

Risk Score ◽

Framingham Risk Score ◽

Tlr Signaling ◽

Ethnic Study ◽

Framingham Risk

Download Full-text

The Detection of Any Coronary Calcium Outperforms Framingham Risk Score as a First Step in Screening for Coronary Atherosclerosis

American Journal of Roentgenology ◽

10.2214/ajr.09.2487 ◽

2010 ◽

Vol 194 (5) ◽

pp. 1235-1243 ◽

Cited By ~ 21

Author(s):

Kevin M. Johnson ◽

David A. Dowe

Keyword(s):

Risk Score ◽

Coronary Atherosclerosis ◽

Framingham Risk Score ◽

Coronary Calcium ◽

Framingham Risk

Download Full-text

The Framingham risk score underestimates the risk of cardiovascular events in the HER2-positive breast cancer population

Current Oncology ◽

10.3747/co.24.3684 ◽

2017 ◽

Vol 24 (5) ◽

pp. 348 ◽

Cited By ~ 14

Author(s):

W. Law ◽

C. Johnson ◽

M. Rushton ◽

S. Dent

Keyword(s):

Breast Cancer ◽

High Risk ◽

Risk Score ◽

Framingham Risk Score ◽

Risk Groups ◽

Left Ventricular ◽

Low Risk ◽

Left Ventricular Ejection ◽

Her2 Positive ◽

Framingham Risk

Introduction Patients with breast cancer (bca) who overexpress her2 (the human epidermal growth factor receptor 2) are at risk for cardiotoxicity when treated with anthracycline-based chemotherapy and her2-targeted agents. The Framingham risk score (frs) is a validated tool that stratifies patients into high-, intermediate-, or low-risk groups and calculates their 10-year risk of developing cardiovascular disease (cvd) based on past medical history, systolic blood pressure, and measurement of serum lipids. We retrospectively analyzed patients with her2-positive bca to determine whether the frs predicts adverse cardiovascular (CV) events or cardiotoxicity in patients treated using anthracyclines or her2-targeted therapy, or both.Methods The frs was determined for patients with bca referred to The Ottawa Hospital Cardiology–Oncology Clinic from October 2008 to August 2014. The patients were stratified into high (≥20%), intermediate (10%–20%), and low (<10%) 10-year cv risk groups. Primary outcomes included cvd-related hospitalizations and deaths, and cardiotoxicity [drop in left ventricular ejection fraction (lvef) of >10% to a lvef ≤50%].Results Of the 152 patients included in the analysis (median follow-up: 40.7 months; range: 3.5–263 months), 47 (31%) were classified as high risk; 36 (24%), as intermediate risk; and 69 (45%), as low-risk. The number of cvd-related hospitalizations and deaths was 22, for an overall prevalence of 14%, with significantly more events occurring in high-risk than in low-risk patients (odds ratio: 4.18; 95% confidence limits: 1.47, 11.89). The frs predicted a 10-year risk of any cv event of 11.2% and underestimated the actual rate of cv events in the entire cohort. High frs was not associated with cardiotoxicity (p = 0.82).Conclusions In a population of patients with her2-positive bca referred to a cardiology–oncology clinic, the frs does not accurately predict the risk of cv events or cardiotoxicity.

Download Full-text