The impact of tumor location on the biological and oncological differences of colon cancer: Multi-institutional propensity score-matched study

Background. There is paucity of data about the impact of using magnification on rate of pancreatic leak after pancreaticoduodenectomy (PD). The aim of this study was to show the impact of using magnifying surgical loupes 4.0× EF (electro-focus) on technical performance and surgical outcomes of PD. Patients and Method. This is a propensity score–matched study. Thirty patients underwent PD using surgical loupes at 4.0× magnification (Group A), and 60 patients underwent PD using the conventional method (Group B). The primary outcome was postoperative pancreatic fistula. Secondary outcomes included operative time, intraoperative blood loss, postoperative complications, mortality, and hospital stay. Results. The total operative time was significantly longer in the loupe group ( P = .0001). The operative time for pancreatic reconstruction was significantly longer in the loupe group ( P = .0001). There were no significant differences between both groups regarding hospital stay, time to oral intake, total amount of drainage, and time of nasogastric tube removal. Univariate and multivariate analyses demonstrated 3 independent factors of development of postoperative pancreatic fistula: pancreatic duct <3 mm, body mass index >25, and soft pancreas. Conclusion. Surgical loupes 4.0× added no advantage in surgical outcomes of PD with regard to improvement of postoperative complications rate or mortality rate.

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Reevaluation of laparoscopic surgery's value in pathological T4 colon cancer with comparison to open surgery: A retrospective and propensity score-matched study

International Journal of Surgery ◽

10.1016/j.ijsu.2018.03.029 ◽

2018 ◽

Vol 53 ◽

pp. 12-17 ◽

Cited By ~ 2

Author(s):

Qi Liu ◽

Dakui Luo ◽

Peng Lian ◽

Wencheng Yu ◽

Ji Zhu ◽

...

Keyword(s):

Colon Cancer ◽

Propensity Score ◽

Open Surgery ◽

T4 Colon Cancer ◽

Matched Study

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Clinical impact of primary tumor location in patients with metastatic colorectal cancer (mCRC) treated with regorafenib or trifluridine/tipiracil as later-line.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.4_suppl.105 ◽

2020 ◽

Vol 38 (4_suppl) ◽

pp. 105-105

Author(s):

Hiromichi Nakajima ◽

Shota Fukuoka ◽

Toshikazu Moriwaki ◽

Toshiki Masuishi ◽

Atsuo Takashima ◽

...

Keyword(s):

Rectal Cancer ◽

Prognostic Factor ◽

Propensity Score ◽

Propensity Score Matching ◽

Primary Tumor ◽

Univariate Analysis ◽

Tumor Location ◽

Primary Tumor Location ◽

The Right ◽

The Impact

105 Background: In the recent years, primary tumor location (PTL) is considered as an important prognostic and predictive factor in first-line treatment of mCRC. Although regorafenib (REG) and trifluridine/tipiracil (TFTD) have been available recently, the prognostic value of PTL in later-line with these agents is not well understood. TFTD improved survival regardless of PTL in the RECOURSE trial, while REG did not show survival benefit in the patients (pts) with rectal cancer in the CORRECT trial. Methods: We retrospectively evaluated pts with mCRC who were registered in a multicenter observational study (the REGOTAS study). The main inclusion criteria were ECOG PS of 0–2, refractory or intolerant to fluoropyrimidines, oxaliplatin, irinotecan, and anti-VEGF and anti-EGFR therapy (if KRAS wild type), and no prior use of REG and TFTD. The impact of PTL on overall survival (OS) were evaluated using Cox proportional hazards models based on baseline characteristics and propensity score matching. Results: A total of 550 pts (223 pts in the REG group, 327 pts in the TFTD group; 122 pts in the right-sided, 428 pts in the left-sided) were included in this study. Although the right-sided pts was significantly shorter OS compared with the left-sided pts by univariate analysis (hazard ratio [HR] 0.79, 95% confidence interval [CI] 0.63-0.99, P = 0.04), multivariate analysis revealed that PTL was not an independent prognostic factor (HR 0.88, 95% CI 0.69-1.1, P = 0.26). The similar results were obtained in each treatment group. In subgroup analysis according to PTL, OS were comparable between REG and TFTD groups regardless of PTL (HR 0.93, 95% CI 0.62-1.39 in the right-sided; HR 1.08, 95% CI 0.83-1.39 in the left-sided [excluding rectum]; and HR 1.01, 95% CI 0.62-1.62 in the rectal cancer pts). These results were similar in sensitivity analysis using propensity score-matching. Conclusions: In the present study, PTL is not a prognostic factor in patient with mCRC treated with either REG or TFTD as later-line. No difference in OS was observed between REG and TFTD groups irrespective of PTL.

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Survival benefit of lymph node dissection in surgery for colon cancer in elderly patients: A multicenter propensity score-matched study in Japan

Asian Journal of Endoscopic Surgery ◽

10.1111/ases.12474 ◽

2018 ◽

Vol 11 (4) ◽

pp. 346-354

Author(s):

Makoto Takahashi ◽

Hiroaki Niitsu ◽

Kazuhiro Sakamoto ◽

Takao Hinoi ◽

Minoru Hattori ◽

...

Keyword(s):

Colon Cancer ◽

Lymph Node ◽

Propensity Score ◽

Elderly Patients ◽

Lymph Node Dissection ◽

Survival Benefit ◽

Node Dissection ◽

Matched Study

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The Impact of Primary Tumor Location on Long-Term Survival in Patients Undergoing Hepatic Resection for Metastatic Colon Cancer

Annals of Surgical Oncology ◽

10.1245/s10434-017-6264-x ◽

2017 ◽

Vol 25 (2) ◽

pp. 431-438 ◽

Cited By ~ 33

Author(s):

John M. Creasy ◽

Eran Sadot ◽

Bas Groot Koerkamp ◽

Joanne F. Chou ◽

Mithat Gonen ◽

...

Keyword(s):

Colon Cancer ◽

Hepatic Resection ◽

Primary Tumor ◽

Tumor Location ◽

Metastatic Colon Cancer ◽

Term Survival ◽

Long Term Survival ◽

Primary Tumor Location ◽

The Impact

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The Impact of Portal Vein Thrombosis on the Prognosis of Patients With Cirrhosis: A Retrospective Propensity-Score Matched Study

Frontiers in Medicine ◽

10.3389/fmed.2021.685944 ◽

2021 ◽

Vol 8 ◽

Author(s):

Zhiji Chen ◽

Tao Ran ◽

Haiyan Cao ◽

Feng Xu ◽

Zhi-hang Zhou ◽

...

Keyword(s):

Propensity Score ◽

Portal Vein ◽

Portal Vein Thrombosis ◽

Serum Sodium Level ◽

Meld Score ◽

Group 14 ◽

Vein Thrombosis ◽

Matched Study ◽

The Impact

Objectives: To investigate the impact of portal vein thrombosis (PVT) on cirrhosis decompensation and survival of cirrhosis.Methods: In this retrospective observational study between January 2012 and August 2020, 117 patients with cirrhotic PVT and 125 patients with cirrhosis were included. Propensity score matching (PSM) was applied to reduce the bias. The clinical characteristics of non-tumoral PVT in cirrhosis and its influence on cirrhosis decompensation and survival were analyzed.Results: The median follow-up for the PVT group was 15 (8.0–23.0) months and for the non-thrombosis group 14 (8.0–23.5) months. The presence of PVT was related with esophageal varices, higher Child-Pugh score and MELD score (P < 0.05). Most PVTs were partial (106/117). Non-occlusive PVT disappeared on later examinations in 32/106 patients (30.19%), of which six patients reappeared. All the 11 patients with occlusive PVT remained occlusive, among which five patients (45.45%) developed portal cavernoma. There was no significant correlation between PVT and decompensation or survival before or after PSM. Multivariate analysis identified only Child-Pugh score (HR = 2.210, 95% CI: 1.332–3.667) and serum sodium level (HR = 0.818, 95% CI: 0.717–0.933) as independent factors for death.Conclusion: Though PVT is associated with greater Child-Pugh score and MELD score, it has no significant impact on the progression of cirrhosis.

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The impact of bile leakage on long-term prognosis in primary liver cancers after hepatectomy: A propensity-score-matched study

Asian Journal of Surgery ◽

10.1016/j.asjsur.2019.08.009 ◽

2020 ◽

Vol 43 (5) ◽

pp. 603-612

Author(s):

Jian Wang ◽

Jian-Ping Zhao ◽

Jing-Jing Wang ◽

Song-Shan Chai ◽

Yu-Xin Zhang ◽

...

Keyword(s):

Propensity Score ◽

Bile Leakage ◽

Liver Cancers ◽

Long Term Prognosis ◽

Matched Study ◽

The Impact

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Adverse Maternal and Neonatal Outcomes in Women With Elevated Intrapartum Temperature Complicated by Histological Chorioamnionitis at Term: A Propensity-Score Matched Study

Frontiers in Pediatrics ◽

10.3389/fped.2021.654596 ◽

2021 ◽

Vol 9 ◽

Author(s):

Yingzhou Ge ◽

Chen Zhang ◽

Yanqing Cai ◽

Hefeng Huang

Keyword(s):

Propensity Score ◽

Stage I ◽

Neonatal Outcomes ◽

Control Group ◽

Prolonged Hospitalization ◽

Positive Rate ◽

Maternal And Neonatal Outcomes ◽

Nicu Admission ◽

Matched Study ◽

The Impact

Background: Elevated intrapartum temperature has been widely proven to be associated with adverse clinical outcomes in both mothers and neonates. Histological chorioamnionitis (HCA), the inflammation of chorion and amniotic membranes, is commonly observed in those with elevated intrapartum temperature. Thus, we aimed to explore whether the combination of HCA would further affect the pregnancy outcomes in those with intrapartum temperature ≥ 37.5°C.Methods: This retrospective cohort study was conducted at the International Peace Maternity and Child Health Hospital (IPMCH), including all full-term women with intrapartum temperature ≥ 37.5°C from Jan 2017 to Jan 2019. Patients were divided in to HCA group or control group according to placental pathology results, and we used 1:1 propensity score matching (PSM) to reduce the effects of potential confounding factors between the two groups. Univariate and multivariable logistic regression were used to identify the association between HCA and different adverse maternal and neonatal outcomes.Results: We formed a propensity-score matched cohort containing 464 women in each group. Higher positive rate of mycoplasma (14.01% vs. 7.33%, p = 0.001) was found in the vaginal secretion culture of women in the HCA group. After adjusting for various baseline clinical characteristics, women with HCA were more likely to end their delivery by cesarean section (AOR = 1.55, 95% CI: 1.05–2.28), and puerperal morbidity (AOR = 2.77, 95% CI: 1.44–5.33) as well as prolonged hospitalization (AOR = 1.56, 95% CI: 1.12–2.17) were more likely to be observed in the HCA group. The existence of HCA might also be associated with neonatal sepsis (AOR = 2.83, 95% CI: 1.14–7.04) and NICU admission (AOR = 1.40, 95% CI: 1.04–1.87) in newborns. In the study on the impact of different stages of HCA, we found that both maternal and neonatal outcomes would not be affected by mild HCA (stage I), while HCA of stage III was associated with increased need for neonatal respiratory support and elevated likelihood of prolonged hospitalization in neonates.Conclusions: Elevated intrapartum temperature complicated by HCA might be related to the elevated occurrence of several adverse maternal and neonatal outcomes, except those with HCA of stage I. Advanced HCA stage correlated with a worse prognosis.

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