Introduction. Acute kidney injury associated with cardiac surgery is a common
and significant postoperative complication. With a frequency of 9 - 39%
according to different studies, it is the second most common cause of acute
kidney injury in intensive care units, and an independent predictor of
mortality. This study aimed to investigate the importance of preoperative
hemoglobin and uric acid levels as risk factors for acute kidney injury in
the postoperative period in cardiac surgery patients. Material and Methods.
The study included a total of 118 patients who were divided into two groups.
Each group included 59 patients; the fist group included patients who
developed acute kidney injury and required renal replacement therapy, and
the second included patients without acute kidney injury. Types of cardiac
surgery included coronary, valvular, combined, aortic dissection, and
others. All necessary data were collected from patient medical records and
the electronic database. Results. A statistically significant difference was
found between the groups in preoperative hemoglobin levels (108.0 vs. 143.0
g/l, p = 0.0005); postoperative urea (26.4 vs. 5.8 mmol/l, p = 0.0005) and
creatinine (371.0 vs. 95.0 ?mol/l, p = 0.0005), acute phase inflammatory
reactants C-reactive protein (119.4 vs. 78.9 mg/l, p = 0.002) and
procalcitonin (7.0 vs. 0.2 ng/ml, p = 0.0005), creatine kinase myocardial
band isoenzyme (1045.0 vs. 647.0 mg/l, p = 0.014); duration of
extracorporeal circulation (103.5 vs. 76.0 min, p = 0.0005) and ascending
aortic clamp during cardiac surgery (89.0 vs. 67.0 min, p = 0.0005). The
exception was the preoperative uric acid level, where there was no
statistically significant difference (382.0 vs. 364.0 ?mol/l, p = 0.068).
There was a statistically significant correlation between the use of
inotropic agents and acute kidney injury development. Conclusion. There is a
correlation between the preoperative low hemoglobin levels and postoperative
acute kidney injury. There is no statistically significant correlation
between the preoperative levels of uric acid and postoperative acute kidney
injury.
Levels of Protein C and Soluble Thrombomodulin in Critically Ill Patients with Acute Kidney Injury: A Multicenter Prospective Observational Study
