This study aims to explore three different structural models of self-efficacy for Filipino Radiologic Technology educators, current learners, and prospective students in the senior high school. Subjects were 256 Radiologic Technology educators (102 males and 154 females) and 2,451 Radiologic Technology students (1,525 males and 926 females), randomly selected from 22 Radiologic Technology schools in the Philippines. A total of 4,263 prospective Radiologic Technology students from the 30 senior high schools in the Philippines were also sampled as respondents. Six instruments were used to measure help-seeking, self-esteem, social support, motivation, self-regulation, and self-efficacy. Path analysis was utilized to identify the best fitting model. The best fit models of self-efficacy for Filipino Radiologic Technology educators and learners showed that help-seeking, self-esteem, social support, motivation, and self-regulation positively influenced self-efficacy, with social support exerting the greatest causal effect. The best fit model of self-efficacy for prospective Radiologic Technology students from senior high school reported that social support completely mediates the effects of help-seeking, self-esteem, motivation, and self-regulation on self-efficacy. The study highlights different results that could be arrived depending on whether future researchers decide to use the self-efficacy models for Filipino Radiologic Technology educators, current learners, and prospective students in the senior high school. The provision of highly supportive environment for Radiologic Technology educators, current learners, and prospective students in the senior high school is essential to increase self-efficacy, thereby improving their capabilities to hurdle the challenges in the academic milieu.