A new approach for simultaneously improved osseointegration and antibacterial activity by electrochemical deposition of graphene nanolayers over titania nanotubes

2021 ◽  
pp. 152263
Author(s):  
Seyed Yahya Rahnamaee ◽  
Reza Bagheri ◽  
Manoucher Vossoughi ◽  
Mona khafaji ◽  
Elham Asadian ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Electrochemical Deposition ◽  
Titania Nanotubes ◽  
New Approach ◽  
Graphene Nanolayers

Synthesis, Characterizations, and Biological Effects Study of Some Quinoline Family

2016 ◽  
pp. 160-196
Author(s):  
Messai Amel
Keyword(s):  
Antibacterial Activity ◽  
Single Crystal ◽  
Biological Activities ◽  
Biological Effects ◽  
Diffusion Method ◽  
Quinoline Derivatives ◽  
Single Crystal Diffraction ◽  
Disk Diffusion Method ◽  
New Approach ◽  
Gram Negative

The objective of this work is the synthesis of new quinoline molecules which could have some biological activities. This chapter reported a new approach to the synthesis of some quinoline derivatives. The Baylis-Hillman reaction on 2-methoxy-3-formyl quinoléines derivatives have applied in order to obtain Baylis-Hillman adducts. The products are characterized by FTIR, NMR and X-ray single crystal diffraction .Also, a study of the antibacterial activity of the 3-(2-chloro quinoline)-3-hydroxy-2 methylene propanonitrile products synthesized have been explored. This assessment is made by using the disk diffusion method. The results showed that the 3-(2'-chloroquinoline)-3-hydroxy-2-methylenepropanonitril derivatives present a good antibacterial effectiveness against the strains tested Gram-positive and no antibacterial potency was observed against the stains Gram-negative used in the test.

A new approach to the synthesis of 2-aryl-substituted benzimidazoles, quinazolines, and other related compounds and their antibacterial activity

2012 ◽  
Vol 23 (3) ◽  
pp. 265-275 ◽  
Author(s):  
Renata Los ◽  
Marta Wesołowska-Trojanowska ◽  
Anna Malm ◽  
Monika M. Karpińska ◽  
Joanna Matysiak ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
New Approach ◽  
Related Compounds

scholarly journals Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1579 ◽  
Author(s):  
Yanmei Zhang ◽  
Xin Zhang ◽  
Jie Song ◽  
Liming Jin ◽  
Xiaotong Wang ◽  
...  
Keyword(s):  
Public Health ◽  
Antibacterial Activity ◽  
Ag Nanoparticles ◽  
Antibacterial Agent ◽  
Pathogenic Bacteria ◽  
Reduction Method ◽  
Antibacterial Activities ◽  
Narrow Size Distribution ◽  
New Approach ◽  
Major Threat

Development of antimicrobial nanomaterials is one of the most attractive strategies for eliminating the major threat of pathogenic bacteria to public health. In this work, we developed a simple impregnation-reduction method for the synthesis of Ag-doped hierarchical ZIF-8 (Ag/H-ZIF-8) nanocomposite. The nanocomposite was characterized by several techniques and its antibacterial activity was investigated. The Ag nanoparticles are uniformly dispersed in the porous ZIF-8 with narrow size distribution. Consequently, the resulting Ag/H-ZIF-8 nanocomposite showed significantly enhanced antibacterial activities compared to the single ZIF-8 or Ag nanoparticles. Furthermore, the composite is biocompatible, because no obvious toxicity was observed on Hepatic epithelial cells. This study offers a new approach for the design of hybrid antimicrobial nanomaterials that have great potentials in practical disinfections

Concise Synthesis and Displacement Reactions of Model 3-(Alkylthio)- 6-chloro- and 2,6-Dichlorothieno[2,3-e][1,4,2]dithiazine 1,1-Dioxides

2011 ◽  
Vol 66 (7) ◽  
pp. 715-720
Author(s):  
Rajab Abu-El-Halawa ◽  
Mohanad Masad ◽  
Yaser Bathich ◽  
Mahmoud Al-Refai ◽  
Mohammad M. Ibrahim ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carbon Disulfide ◽  
Dimethyl Sulfate ◽  
Alkyl Halides ◽  
Sulfuryl Chloride ◽  
Molar Ratio ◽  
New Approach ◽  
E Coli ◽  
Displacement Reactions

A series of 3-(alkylthio)-6-chlorothieno[2,3-e][1,4,2]dithiazine 1,1-dioxides (7a - e) were prepared via interaction of deprotonated 2,5-dichlorothiophene-3-sulfonamide with carbon disulfide under reflux, followed by alkylation with alkyl halides. Employment of dimethyl sulfate afforded the isomeric 2-methyl-3-thione derivative 8 together with the expected 3-(methylthio) derivative 7a in a molar ratio of 1 : 4. Treatment of 7a or 10 with ethylamine, aniline or p-chloroaniline produced the corresponding N-ethyl- (or N-phenyl)-6-chlorothieno[2,3-e][1,4,2]dithiazine-3-amine 1,1-dioxides 3a - c. Likewise, interaction of 7a with methylhydrazine (or phenylhydrazine) gave the respective 3-(1-methylhydrazinyl or 2-phenylhydrazinyl) 1,1-dioxides 9a, b. Desulfonation of 6-chloro-3-(methylthio)thieno[ 2,3-e][1,4,2]dithiazine 1,1-dioxide (7a) with sulfuryl chloride produced 3,6-dichlorothieno[2,3- e][1,4,2]dithiazine 1,1-dioxide (10). The latter compound was used as a substrate for the preparation of N-alkyl- (or aryl)-6-chlorothieno[2,3-e][1,4,2]dithiazin-3-amine 1,1-dioxides 3a - c representing a new approach for the synthesis of similar derivatives. Compounds 7a - e showed modest to low antibacterial activity against E. coli and S. aureus.

scholarly journals Quantification of bee-derived peptide defensin-1 in honey by competitive enzyme-linked immunosorbent assay, a new approach in honey quality control

2016 ◽  
Vol 34 (No. 3) ◽  
pp. 233-243 ◽  
Author(s):  
Valachová Ivana ◽  
Bučeková Marcela ◽  
Majtán Juraj
Keyword(s):  
Antibacterial Activity ◽  
Immunosorbent Assay ◽  
Inhibitory Concentration ◽  
Rapid Screening ◽  
Enzyme Linked Immunosorbent Assay ◽  
New Approach ◽  
Relative Standard ◽  
Dependent Correlation ◽  
Sensitive Method ◽  
Significant Concentration

We established and evaluated a polyclonal antibody based competitive enzyme-linked immunosorbent assay for the quantification of defensin-1 in honey. The assay showed an inhibitory concentration (IC<sub>50</sub>) value of 111.5 ± 15.41 ng/ml with a detection limit of 7.8125 ng/ml. The regaining of defensin-1 in spiked ‘artificial honey’ was between 87.05 and 112.96% with relative standard deviation less than 9.2%. Sensitivity and specificity of the test were experimentally validated on a sample of 20 different honeys. The antibacterial activity of these honey samples showed a significant concentration-dependent correlation with the production of defensin-1 (n = 20; r = −0.6598; P = 0.0016). The assay provides a specific and sensitive method for the screening of defensin-1 in honey. The method to detect honeybee-derived proteins in honey is a promising approach to verifying the authenticity of honey. The defensin-1 ELISA could also be used for the rapid screening of honeys suitable for medicinal purposes.

ChemInform Abstract: A New Approach to the Synthesis of 2-Aryl-Substituted Benzimidazoles, Quinazolines, and Other Related Compounds and Their Antibacterial Activity.

ChemInform ◽  
2012 ◽  
Vol 43 (37) ◽  
pp. no-no
Author(s):  
Renata Los ◽  
Marta Wesolowska-Trojanowska ◽  
Anna Malm ◽  
Monika M. Karpinska ◽  
Joanna Matysiak ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
New Approach ◽  
Related Compounds

New approach to 5-arylamino-4-(5-aryloxyfuran-2-yl)pyrimidines: synthesis and antibacterial activity

2021 ◽  
Vol 70 (5) ◽  
pp. 937-942
Author(s):  
E. V. Verbitskiy ◽  
S. A. Baskakova ◽  
G. L. Rusinov ◽  
V. N. Charushin
Keyword(s):  
Antibacterial Activity ◽  
New Approach
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