Nanotechnology improves the therapeutic efficacy of Melaleuca alternifolia essential oil in experimentally infected Rhamdia quelen with Pseudomonas aeruginosa

Aquaculture ◽  
2017 ◽  
Vol 473 ◽  
pp. 169-171 ◽  
Author(s):  
Carine F. Souza ◽  
Matheus D. Baldissera ◽  
Roberto C.V. Santos ◽  
Renata P. Raffin ◽  
Bernardo Baldisserotto
Author(s):  
Carine de Freitas Souza ◽  
Matheus Dellaméa Baldissera ◽  
Sharine Descovi ◽  
Carla Zeppenfeld ◽  
Pedro Rene Eslava-Mocha ◽  
...  

2016 ◽  
Vol 98 ◽  
pp. 82-87 ◽  
Author(s):  
Carine F. Souza ◽  
Matheus D. Baldissera ◽  
Rodrigo A. Vaucher ◽  
Leonardo Q.S. Lopes ◽  
Bruno S. Vizzotto ◽  
...  

2017 ◽  
Vol 108 ◽  
pp. 61-65 ◽  
Author(s):  
Carine F. Souza ◽  
Matheus D. Baldissera ◽  
Naiara S. Guarda ◽  
Yãnaí S. Bollick ◽  
Rafael N. Moresco ◽  
...  

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2672 ◽  
Author(s):  
Emira Noumi ◽  
Abderrahmen Merghni ◽  
Mousa M. Alreshidi ◽  
Ons Haddad ◽  
Gültekin Akmadar ◽  
...  

The problem of antibiotic resistance among pathogens encourages searching for novel active molecules. The aim of the research was to assay the anti-quorum sensing (anti-QS) and antibiofilm potential of Melaleuca alternifolia essential oil and its main constituent, terpinen-4-ol, to prevent the infections due to methicillin-resistant Staphylococcus aureus strains as an alternate to antibiotics. The tea tree oil (TTO) was evaluated for its potential in inhibiting QS-dependent phenomena such as violacein production in Chromobacterium violaceum, swarming motility of Pseudomonas aeruginosa PAO1, and biofilm formation in MRSA strains on glass. The results showed that terpinen-4-ol was able to inhibit MRSA strain biofilm formation on the glass strips by 73.70%. TTO inhibited the violacein production at a mean inhibitory concentration (MIC) value of 0.048 mg/mL by 69.3%. At 100 µg/mL TTO and terpinen-4-ol exhibited inhibition in swarming motility of PAO1 by 33.33% and 25%, respectively. TTO revealed anti-QS and anti-biofilm activities at very low concentrations, but it could be further investigated for new molecules useful for the treatment of MRSA infections.


2018 ◽  
Vol 16 (S1) ◽  
pp. S155-S163 ◽  
Author(s):  
S. Mehalaine ◽  
O. Belfadel ◽  
T. Menasria ◽  
A. Messaili

The present study was carried out to determine, for the first time, the chemical composition and antibacterial activity of essential oils derived from the aerial parts of three aromatic plants Thymus algeriensis Boiss & Reut, Rosmarinus officinalis L., and Salvia officinalis L. growing under semiarid conditions. The essential oils were chemically analyzed and identified by gas chromatography (GC) and GC/ mass spectrometry (GC/MS) and their antimicrobial activity was individually evaluated against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using both agar disk diffusion and agar dilution methods. The major constituents of Thymus algeriensis essential oil were identified as camphor (13.62%), 1,8-cineol (6.00%), borneol (5.74%), viridiflorol (4.00%), and linalool (3.93%). For Rosmarinus officinalis essential oil, 48 compounds were characterized, of which the main constituents were camphor (17.09%), Z-β-ocimene (10.88%), isoborneol (9.68%), α-bisabolol (7.89%), and borneol (5.11%). While, Salvia officinalis essential oil was characterized by β-thujone (16.44%), followed by viridiflorol (10.93%), camphor (8.99%), 1,8-cineol (8.11%), trans-caryophyllene (5.85%), and α-humulene (4.69%) as the major components. Notably, results from antibacterial screening indicated that Thymus algeriensis and Salvia officinalis essential oils exhibited a strong inhibitory effect against both Escherichia coli and Staphylococcus aureus compared to Rosmarinus officinalis essential oil. Further, less activity was recorded against Pseudomonas aeruginosa for the three tested essential oils.


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