Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis?

2017 ◽  
Vol 81 ◽  
pp. 61-68 ◽  
Author(s):  
Umut Yiğit ◽  
Fatma Yeşim Kırzıoğlu ◽  
Abdülhadi Cihangir Uğuz ◽  
Mustafa Nazıroğlu ◽  
Özlem Özmen
2021 ◽  
Author(s):  
Esra DEMİR ◽  
Feyza Otan ÖZDEN ◽  
Bahattin AVCI

Abstract Caffeic acid phenethyl ester (CAPE) is an active component of propolis extracts and has anti-inflammatory, antioxidant, immunomodulatory activities. This study aims to investigate the anti-inflammatory effect of two different dosages of CAPE on lipopolysaccharide-induced experimental periodontitis (EP). Forty Sprague Dawley rats were randomly divided into four groups: control, EP, EP treated with 5 µmol/kg/day of CAPE (EP + CAPE 5), and EP treated with 10 µmol/kg/day of CAPE (EP + CAPE 10). Followed by the EP, CAPE was administered intraperitoneally to the EP + CAPE groups for 28 days. Samples were investigated biochemically using an enzyme linked immunoassay (ELISA) kit and alveolar bone loss was measured morphometrically. In both of the CAPE groups, the levels of IL-1β and TNF-α in the gingiva were significantly lower than those in the EP group (p < 0.001). The decrease in tissue levels of TNF-α was greater in the EP + CAPE 10 group than in the EP + CAPE 5 group in a dose-dependent manner. Serum analysis of the cytokines showed no significant difference between the groups. Within the limits of this study, CAPE showed its anti-inflammatory effect by reducing pro-inflammatory cytokines in gingiva and is claimed to be a novel agent in improving the results of periodontal therapy without any known side effects.


2019 ◽  
pp. 114-120
Author(s):  
Alper KIZILDAĞ ◽  
Taner Arabacı ◽  
Mevlüt Albayrak ◽  
Ufuk Taşdemir ◽  
Mukaddes Mergen Dalyanoğlu ◽  
...  

Author(s):  
Valeria Pittala ◽  
Luca Vanella ◽  
Loredana Salerno ◽  
Claudia Di Giacomo ◽  
Rosaria Acquaviva ◽  
...  

2021 ◽  
Vol 64 (1) ◽  
Author(s):  
Aslı Özkök ◽  
Merve Keskin ◽  
Aslı Elif Tanuğur Samancı ◽  
Elif Yorulmaz Önder ◽  
Çiğdem Takma

AbstractThis study aimed to determine the standard amount of antioxidant content and compounds of the propolis for the standardization of propolis. For this purpose, the total flavonoids, total phenolic, CUPRAC antioxidant capacity content and the diversity of phenolic and flavonoid components of these propolis samples were found by HPLC determined at the 23 propolis samples which were collected different regions of Turkey. Beside that, the similarities and differences of these 23 provinces to each other according to their antioxidant capacities were investigated by multidimensional scaling analysis. The total flavonoid content in the propolis samples were determined between 21.28 and 152.56 mg CE/g. The total phenolic content in the propolis samples was found between 34.53 mg and 259.4 mg GAE/g. CUPRAC antioxidant capacity of the propolis samples and antioxidant range was found from 95.35 to 710.43 mg TE/g. Also, 4 flavonoid [Quercetin (min.1.12–max.4.14 mg/g), Galangin (min.0.72–max.40.79 mg/g), Apigenin (min.1.07–max.17.35 mg/g), Pinocembrin (min.1.32–max.39.92 mg/g] and 6 phenolic acid [Caffeic acid (min.1.20–max.7.6 mg/g), p-Coumaric acid (min.1.26–max.4.47 mg/g), trans-Ferulic acid (min.1.28–max.4.92 mg/g), Protocatechuic acid (1.78 mg/g), trans-Cinnamic acid (min.1.05–max.3.83 mg/g), Caffeic Acid Phenethyl Ester (CAPE) (min.1.41–max.30.15 mg/g)] components were detected as mg/g, in different ratios in propolis samples collected from different regions. The feature of this study, so far, is to have the maximum number of samples representing the Turkish propolis, and so is thought to help to national and international propolis standard workings.


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