Methionine as a double-edged sword in health and disease: Current perspective and future challenges

2021 ◽  
pp. 101500
Author(s):  
Umashanker Navik ◽  
Vaibhav G. Sheth ◽  
Amit Khurana ◽  
Snehal Sainath Jawalekar ◽  
Prince Allawadhi ◽  
...  
Keyword(s):  
Current Perspective ◽  
Future Challenges ◽  
Health And Disease

RNAi for Insect Control: Current Perspective and Future Challenges

2013 ◽  
Vol 171 (4) ◽  
pp. 847-873 ◽  
Author(s):  
Rajan Katoch ◽  
Amit Sethi ◽  
Neelam Thakur ◽  
Larry L. Murdock
Keyword(s):  
Insect Control ◽  
Control Current ◽  
Current Perspective ◽  
Future Challenges

scholarly journals Protein S-nitrosylation in health and disease: a current perspective

2009 ◽  
Vol 15 (9) ◽  
pp. 391-404 ◽  
Author(s):  
Matthew W. Foster ◽  
Douglas T. Hess ◽  
Jonathan S. Stamler
Keyword(s):  
Protein S ◽  
Current Perspective ◽  
Health And Disease ◽  
A Current

Computer simulations of ABC transporter componentsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.

2006 ◽  
Vol 84 (6) ◽  
pp. 900-911 ◽  
Author(s):  
Eliud O. Oloo ◽  
Christian Kandt ◽  
Megan L. O’Mara ◽  
D. Peter Tieleman
Keyword(s):  
Abc Transporters ◽  
Simulation Techniques ◽  
Multiple Components ◽  
Functional Dynamics ◽  
Future Challenges ◽  
Health And Disease ◽  
Dynamics Simulations ◽  
Functional Mechanisms ◽  
Computer Simulation Techniques ◽  
Selection Of

Current computer simulation techniques provide robust tools for studying the detailed structure and functional dynamics of proteins, as well as their interaction with each other and with other biomolecules. In this minireview, we provide an illustration of recent progress and future challenges in computer modeling by discussing computational studies of ATP-binding cassette (ABC) transporters. ABC transporters have multiple components that work in a well coordinated fashion to enable active transport across membranes. The mechanism by which members of this superfamily execute transport remains largely unknown. Molecular dynamics simulations initiated from high-resolution crystal structures of several ABC transporters have proven to be useful in the investigation of the nature of conformational coupling events that may drive transport. In addition, fruitful efforts have been made to predict unknown structures of medically relevant ABC transporters, such as P-glycoprotein, using homology-based computational methods. The various techniques described here are also applicable to gaining an atomically detailed understanding of the functional mechanisms of proteins in general.

scholarly journals Brain tumor research in the United Kingdom: current perspective and future challenges. A strategy document from the NCRI Brain Tumor CSG

2017 ◽  
Vol 5 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Kathreena M Kurian ◽  
Michael D Jenkinson ◽  
Paul M Brennan ◽  
Robin Grant ◽  
Sarah Jefferies ◽  
...  
Keyword(s):  
United Kingdom ◽  
Brain Tumor ◽  
Research Priorities ◽  
Research Network ◽  
The United Kingdom ◽  
Current Perspective ◽  
National Cancer Research Institute ◽  
Future Challenges ◽  
Tumor Research ◽  
Brain Tumor Research

Abstract The National Cancer Research Institute (NCRI) is a partnership of charity and government research funders whose purpose is to improve health and quality of life by accelerating progress in cancer-related research through collaboration. Under this umbrella, the NCRI Brain Tumor Clinical Studies Group is focused on improving clinical outcomes for adult patients with brain and central nervous system tumors, including those with brain metastasis from other primary sites. This document discusses the current state of clinical brain tumor research in the United Kingdom and the challenges to increasing study and trial opportunities for patients. The clinical research priorities are defined along with a strategy to strengthen the existing brain tumor research network, improve access to tissue and imaging and to develop the future leadership for brain tumor research in the United Kingdom. This strategy document may serve as a framework for other organizations and countries.

Drug Induced Changes in Cell Organelles

1968 ◽  
Vol 26 ◽  
pp. 110-111
Author(s):  
Sarah A. Luse
Keyword(s):  
Clinical Medicine ◽  
Cell Organelles ◽  
Riboflavin Deficiency ◽  
Drug Induced ◽  
New Era ◽  
Health And Disease ◽  
In The Beginning ◽  
Cellular Pathology ◽  
Induced Changes ◽  
The Impact

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.

ACE2 as therapeutic agent

2020 ◽  
Vol 134 (19) ◽  
pp. 2581-2595
Author(s):  
Qiuhong Li ◽  
Maria B. Grant ◽  
Elaine M. Richards ◽  
Mohan K. Raizada
Keyword(s):  
Therapeutic Agent ◽  
Renin Angiotensin System ◽  
Peptide Hormone ◽  
Experimental Models ◽  
Electrolyte Balance ◽  
Ang Ii ◽  
Angiotensin Converting Enzyme 2 ◽  
Beneficial Effects ◽  
Overwhelming Evidence ◽  
Future Challenges

Abstract The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance. ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to form Angiotensin-(1-7) (Ang-(1-7)), which binds to the G-protein–coupled Mas receptor and activates signaling pathways that counteract the pathways activated by Ang-II. ACE2 is expressed in a variety of tissues and overwhelming evidence substantiates the beneficial effects of enhancing ACE2/Ang-(1-7)/Mas axis under many pathological conditions in these tissues in experimental models. This review will provide a succinct overview on current strategies to enhance ACE2 as therapeutic agent, and discuss limitations and future challenges. ACE2 also has other functions, such as acting as a co-factor for amino acid transport and being exploited by the severe acute respiratory syndrome coronaviruses (SARS-CoVs) as cellular entry receptor, the implications of these functions in development of ACE2-based therapeutics will also be discussed.

The Laryngeal Epithelium in Reflux

2011 ◽  
Vol 21 (3) ◽  
pp. 112-117 ◽  
Author(s):  
Elizabeth Erickson-Levendoski ◽  
Mahalakshmi Sivasankar
Keyword(s):  
Laryngopharyngeal Reflux ◽  
Critical Role ◽  
Structure And Function ◽  
Laryngeal Disease ◽  
Health And Disease ◽  
And Function ◽  
The Impact

The epithelium plays a critical role in the maintenance of laryngeal health. This is evident in that laryngeal disease may result when the integrity of the epithelium is compromised by insults such as laryngopharyngeal reflux. In this article, we will review the structure and function of the laryngeal epithelium and summarize the impact of laryngopharyngeal reflux on the epithelium. Research investigating the ramifications of reflux on the epithelium has improved our understanding of laryngeal disease associated with laryngopharyngeal reflux. It further highlights the need for continued research on the laryngeal epithelium in health and disease.

Studies on Gastric Mucus in Health and Disease

1965 ◽  
Vol 48 (6) ◽  
pp. 758-767 ◽  
Author(s):  
Lansing C. Hoskins ◽  
Norman Zamcheck
Keyword(s):  
Gastric Mucus ◽  
Health And Disease
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