Porphyromonas gingivalis vesicles reduce MDA-LDL levels and aortic wall thickness in high fat diet induced atherosclerosis rats

2018 ◽  
Vol 23 (C) ◽  
pp. 20 ◽  
Author(s):  
Aditya Indra Mahendra ◽  
Jonny Karunia Fajar ◽  
Harapan Harapan ◽  
Teuku Heriansyah ◽  
Sumarno Reto Prawiro ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Wall Thickness ◽  
High Fat Diet ◽  
Aortic Wall ◽  
High Fat ◽  
Aortic Wall Thickness

scholarly journals Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sldmice

2004 ◽  
Vol 13 (5-6) ◽  
pp. 335-341 ◽  
Author(s):  
Kottarappat N. Dileepan ◽  
Thomas P. Johnston ◽  
Yuai Li ◽  
Ossama Tawfik ◽  
Daniel J. Stechschulte
Keyword(s):  
Wall Thickness ◽  
Peripheral Blood ◽  
High Fat Diet ◽  
Aortic Wall ◽  
Plasma Cholesterol ◽  
High Fat ◽  
Dietary Regimen ◽  
Plasma Triglycerides ◽  
Aortic Wall Thickness ◽  
The Impact

STUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sldmouse. The results demonstrated that the mean aortic wall thickness of Sl/Sldmice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sldgenotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sldmice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sldmice.

Anti-atherosclerotic activity of aqueous extract of Ipomoea batatas (L.) leaves in high-fat diet-induced atherosclerosis model rats

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Budi Arief Waskito ◽  
Djanggan Sargowo ◽  
Umi Kalsum ◽  
Askandar Tjokroprawiro
Keyword(s):  
Cardiovascular Diseases ◽  
Wall Thickness ◽  
High Fat Diet ◽  
Ipomoea Batatas ◽  
Leaf Extract ◽  
Aortic Wall ◽  
Amino Acid Content ◽  
Foam Cells ◽  
High Fat ◽  
Aortic Wall Thickness

Abstract Objectives Cardiovascular diseases, especially atherosclerosis, are the leading cause of human mortality in Indonesia. Ipomoea batatas (L.) is a food plant used in Indonesian traditional medicine to treat cardiovascular diseases and related conditions. We assessed the anti-atherosclerotic activity of the aqueous extract of I. batatas leaves in a rat model of high-fat diet-induced atherosclerosis and its mechanism. Methods The presence of amino acid content in the I. batatas L. purple variant was determined by liquid chromatography high-resolution mass spectrometry (LC-HRMS). Thirty male Wistar rats were divided into five groups (n=6/group), i.e., standard diet group (SD), high-fat diet group (HF), and HF plus I. batatas L. extracts orally (625; 1,250; or 2,500 mg/kg) groups. The numbers of macrophages and aortic wall thickness were analyzed histologically. Immunohistochemical analyses were performed to assess foam cells-oxidized low-density lipoprotein (oxLDL), endothelial nitric oxide synthase (eNOS), and vascular endothelial growth factor (VEGF) expression in the aorta. Results LC-HRMS analysis showed nine amino acid content were identified from I. batatas L. In vivo study revealed that oral administration of I. batatas L. leaf extract alleviated foam cells-oxLDL formation and aortic wall thickness caused by high-fat diet atherosclerosis rats. Further, I. batatas L. leaf extract promoted the number of macrophages and modulated VEGF and eNOS expression in the aorta. Conclusions I. batatas L. leaf extract shows a positive anti-atherosclerosis effect. Furthermore, the mechanism may promote the macrophages, eNOS, VEGF expressions, and inhibition of foam cells-oxLDL formation and aortic wall thickness with the best dosage at 2,500 mg/kg. This could represent a novel approach to prevent cardiovascular diseases.

Maternal undernutrition reduces aortic wall thickness and elastin content in offspring rats without altering endothelial function

2006 ◽  
Vol 111 (4) ◽  
pp. 281-287 ◽  
Author(s):  
Michael R. Skilton ◽  
Alison K. Gosby ◽  
Ben J. Wu ◽  
Lisa M. L. Ho ◽  
Roland Stocker ◽  
...  
Keyword(s):  
Wall Thickness ◽  
Aortic Wall ◽  
Infant Nutrition ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Organ Bath ◽  
High Fat ◽  
Maternal Undernutrition ◽  
Low Protein ◽  
Aortic Wall Thickness

Epidemiological studies suggest a link between fetal/early infant nutrition and adult coronary artery disease. In the present study, we examined the effects of altering nutrition during gestation, lactation and juvenile life on aortic structure and function in rats. Wistar rat dams were fed either a control or low-protein diet throughout pregnancy, or a low-protein diet for the final 7 days of gestation only. At 21 days post-partum, male pups were weaned on to a control, low-protein or high-fat diet. At 12 weeks, the offspring rats were killed. In 46 rats, aortic sections were mounted and stained to assess media thickness and elastin content. In a further 38 rats, aortic rings were suspended in an organ bath and vascular reactivity was tested with dose–response curves to the endothelium-dependent dilator acetylcholine and the endothelium-independent dilator sodium nitroprusside. Rats exposed to maternal protein restriction while in utero had a significantly decreased aortic wall thickness compared with control rats (P=0.005). Total elastin content of the aorta was also decreased by both maternal low-protein (P=0.02) and early postnatal low-protein (P=0.01) diets. Neither maternal nor postnatal low-protein or high-fat diets, however, resulted in any significant changes in arterial dilator function. In conclusion, fetal undernutrition in rats, induced via a maternal low-protein diet, causes a decrease in aortic wall thickness and elastin content without altering aortic dilator function. These changes in vascular structure may amplify aging-related changes to the vasculature and contribute to the pathophysiology of the putative link between impaired fetal growth and adult cardiovascular disease.

AB0967 Determinants of Aortic Wall Thickness in Patients without Aortitis: A Computed Tomography-Based Study: Table 1

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 1119.3-1120
Author(s):  
A. Nakhleh ◽  
D. Rimar ◽  
I. Rukhkyan ◽  
V. Wolfson ◽  
I. Rosner ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Wall Thickness ◽  
Aortic Wall ◽  
Aortic Wall Thickness

scholarly journals Validation of semiautomated and locally resolved aortic wall thickness measurements from computed tomography

2015 ◽  
Vol 61 (4) ◽  
pp. 1034-1040 ◽  
Author(s):  
Eric K. Shang ◽  
Eric Lai ◽  
Alison M. Pouch ◽  
Robin Hinmon ◽  
Robert C. Gorman ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Wall Thickness ◽  
Aortic Wall ◽  
Aortic Wall Thickness ◽  
Thickness Measurements

Abstract P363: Visceral, but Not Subcutaneous Adiposity by Computed Tomography is Associated With Increased Aortic Wall Thickness in Psoriasis Patients

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Jacob W Groenendyk ◽  
Parag Shukla ◽  
Youssef A Elnabawi ◽  
Joshua P Rivers ◽  
Aditya Goyal ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Wall Thickness ◽  
Aortic Wall ◽  
Subclinical Atherosclerosis ◽  
Visceral Adiposity ◽  
Framingham Risk ◽  
High Prevalence ◽  
Multivariable Regression ◽  
Aortic Wall Thickness ◽  
Subcutaneous Adiposity

Introduction: Patients with psoriasis (PSO), an inflammatory skin disease, experience increased cardiovascular disease and obesity. Traditional measures of obesity, such as BMI and waist-to-hip ratio (WHR), do not fully capture the increased cardiovascular risk. Assessment of adipose tissue distribution via CT scan enables characterization of visceral adiposity (VAT) versus subcutaneous adiposity (SAT), which is clinically useful as excess VAT is known to be associated with cardiovascular events. Aortic Wall Thickness (AWT) is a validated measure of subclinical atherosclerosis. However, the relationship between adiposity distribution and AWT is unknown. Hypothesis: We hypothesized that VAT, but not SAT, BMI, or WHR, would be associated with increased AWT in PSO patients. Methods: Consecutive PSO patients (n=164) underwent quantification of VAT and SAT via CT, and AWT via MRI of the descending aorta. Interrelationships were analyzed via multivariable regression. Results: Patients were middle-aged (mean 50.4), predominantly male (56%), and were at low cardiovascular risk (median Framingham risk 3), despite high prevalence of hyperlipidemia (47%). VAT was significantly associated with AWT (β=0.18, p=0.04), SAT, BMI, or WHR did not demonstrate similar association. This association persisted beyond adjustment for SAT, Framingham score, insulin resistance, and systolic BP (β=0.30, p=0.03). Conclusions: Visceral adiposity demonstrated an association with AWT, a marker of early atherosclerosis, whereas subcutaneous adiposity, BMI, and WHR did not. These findings add to a growing body of literature that visceral fat and its assessment may provide incremental data for risk of subclinical CVD.

Aortic stiffness is associated with vascular calcification and remodeling in a chronic kidney disease rat model

2011 ◽  
Vol 300 (6) ◽  
pp. F1431-F1436 ◽  
Author(s):  
Keith Ng ◽  
Cara M. Hildreth ◽  
Jacqueline K. Phillips ◽  
Alberto P. Avolio
Keyword(s):  
Chronic Kidney Disease ◽  
Smooth Muscle ◽  
Kidney Disease ◽  
Wall Thickness ◽  
Vascular Remodeling ◽  
Aortic Stiffness ◽  
Aortic Wall ◽  
Strong Predictor ◽  
Aortic Calcification ◽  
Aortic Wall Thickness

Increased aortic pulse-wave velocity (PWV) reflects increased arterial stiffness and is a strong predictor of cardiovascular risk in chronic kidney disease (CKD). We examined functional and structural correlations among PWV, aortic calcification, and vascular remodeling in a rodent model of CKD, the Lewis polycystic kidney (LPK) rat. Hemodynamic parameters and beat-to-beat aortic PWV were recorded in urethane-anesthetized animals [12-wk-old hypertensive female LPK rats ( n = 5)] before the onset of end-stage renal disease and their age- and sex-matched normotensive controls (Lewis, n = 6). Animals were euthanized, and the aorta was collected to measure calcium content by atomic absorption spectrophotometry. A separate cohort of animals ( n = 5/group) were anesthetized with pentobarbitone sodium and pressure perfused with formalin, and the aorta was collected for histomorphometry, which allowed calculation of aortic wall thickness, medial cross-sectional area (MCSA), elastic modulus (EM), and wall stress (WS), size and density of smooth muscle nuclei, and relative content of lamellae, interlamellae elastin, and collagen. Mean arterial pressure (MAP) and PWV were significantly greater in the LPK compared with Lewis (72 and 33%, respectively) animals. The LPK group had 6.8-fold greater aortic calcification, 38% greater aortic MCSA, 56% greater EM/WS, 13% greater aortic wall thickness, 21% smaller smooth muscle cell area, and 20% less elastin density with no difference in collagen fiber density. These findings demonstrate vascular remodeling and increased calcification with a functional increase in PWV and therefore aortic stiffness in hypertensive LPK rats.

Measurement of aortic-wall thickness in living dogs

1973 ◽  
Vol 11 (1) ◽  
pp. 39-42 ◽  
Author(s):  
A. E. Marble ◽  
W. Hilliard ◽  
A. S. MacDonald ◽  
C. H. Miller ◽  
J. G. Holland ◽  
...  
Keyword(s):  
Wall Thickness ◽  
Aortic Wall ◽  
Aortic Wall Thickness
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