scholarly journals Assessment of Hip Translation In Vivo in Patients With Femoracetabular Impingement Syndrome Using 3-Dimensional Computed Tomography

2020 ◽  
Vol 2 (2) ◽  
pp. e113-e120
Author(s):  
Gregory L. Cvetanovich ◽  
Edward C. Beck ◽  
Peter N. Chalmers ◽  
Alejandro A. Espinoza Orías ◽  
Michael D. Stover ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Impingement Syndrome ◽  
3 Dimensional ◽  
Femoracetabular Impingement

scholarly journals Quantification of Acetabular Coverage on 3-Dimensional Reconstructed Computed Tomography Scan Bone Models in Patients With Femoroacetabular Impingement Syndrome: A Descriptive Study

2021 ◽  
Vol 9 (11) ◽  
pp. 232596712110494
Author(s):  
Steven F. DeFroda ◽  
Thomas D. Alter ◽  
Floor Lambers ◽  
Philip Malloy ◽  
Ian M. Clapp ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Femoral Head ◽  
Femoroacetabular Impingement ◽  
Impingement Syndrome ◽  
Acetabular Coverage ◽  
Level Of Evidence ◽  
Average Percentage ◽  
3 Dimensional ◽  
Inferior Aspect ◽  
Femoroacetabular Impingement Syndrome

Background: Accurate assessment of osseous morphology is imperative in the evaluation of patients with femoroacetabular impingement syndrome (FAIS) and hip dysplasia. Through use of computed tomography (CT), 3-dimensional (3D) reconstructed hip models may provide a more precise measurement for overcoverage and undercoverage and aid in the interpretation of 2-dimensional radiographs obtained in the clinical setting. Purpose: To describe new measures of acetabular coverage based on 3D-reconstructed CT scan bone models. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Preoperative CT scans were acquired on the bilateral hips and pelvises of 30 patients before arthroscopic surgical intervention for FAIS. Custom software was used for semiautomated segmentation to generate 3D osseous models of the femur and acetabulum that were aligned to a standard coordinate system. This software calculated percentage of total acetabular coverage, which was defined as the surface area projected onto the superior aspect of the femoral head. The percentage of coverage was also quantified regionally in the anteromedial, anterolateral, posteromedial, and posterolateral quadrants of the femoral head. The acetabular clockface was established by defining 6 o’clock as the inferior aspect of the acetabular notch. Radial coverage was then calculated along the clockface from the 9-o’clock to 5-o’clock positions. Results: The study included 20 female and 10 male patients with a mean age of 33.6 ± 11.7 years and mean body mass index of 27.8 ± 6.3. The average percentage of total acetabular coverage for the sample was 57% ± 6%. Acetabular coverages by region were as follows: anteromedial, 78% ± 7%; anterolateral, 18% ± 7%, posterolateral, 33% ± 13%, and posteromedial, 99% ± 1%. The acetabular coverage ranged from 23% to 69% along the radial clockface from 9 to 5 o’clock. Conclusion: This study demonstrated new 3D measurements to characterize acetabular coverage in patients with FAIS and elucidated the distribution of acetabular coverage according to these measurements.

Reproducibility of Bone Microstructure and Stiffness Measurements in Rats by In Vivo Micro Computed Tomography and Finite Element Analysis

2012 ◽  
Author(s):  
Shenghui Lan ◽  
Abhishek Chandra ◽  
Ling Qin ◽  
X. Sherry Liu
Keyword(s):  
Computed Tomography ◽  
Mechanical Properties ◽  
Finite Element ◽  
Recent Decade ◽  
Micro Computed Tomography ◽  
Element Analysis ◽  
3 Dimensional ◽  
Bone Changes ◽  
Μct Scan

Micro computed tomography (μCT) has been widely used to study 3-dimensional (3D) microstructure of bone specimens. In the recent decade, in vivo μCT scanners have become available to monitor longitudinal bone changes in rodents (1,2). The current in vivo μCT scan can obtain images with an isotropic voxel size up to 10.5 μm, which is high enough for direct 3D bone microstructural analyses. Moreover, based on these high-resolution images, micro finite element (μFE) models can be generated to estimate mechanical properties of bone. Therefore, by using in vivo μCT imaging and μFE analysis techniques, changes in geometry, microstructure, and mechanical properties of rodent bone, in response to either diseases or treatments, can be visualized and quantified over time.

42-OR: Hub Cells Orchestrate 3-Dimensional Pancreatic Beta-Cell Ca2+ Dynamics In Vivo

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 42-OR
Author(s):  
VICTORIA SALEM ◽  
LUIS F. DELGADILLO SILVA ◽  
KINGA SUBA ◽  
ALDARA MARTIN ALONSO ◽  
WHEI-CHANG KIM ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
3 Dimensional

Tantalum Oxide Nanoparticles as Versatile Contrast Agents for X-ray Computed Tomography

2020 ◽  
Author(s):  
Shatadru Chakravarty ◽  
Jeremy Hix ◽  
Kaitlyn Wieweora ◽  
Maximilian Volk ◽  
Elizabeth Kenyon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Tantalum Oxide ◽  
High Signal ◽  
Drug Delivery Vehicles ◽  
X Ray Computed

Here we describe the synthesis, characterization and in vitro and in vivo performance of a series of tantalum oxide (TaOx) based nanoparticles (NPs) for computed tomography (CT). Five distinct versions of 9-12 nm diameter silane coated TaOx nanocrystals (NCs) were fabricated by a sol-gel method with varying degrees of hydrophilicity and with or without fluorescence, with the highest reported Ta content to date (78%). Highly hydrophilic NCs were left bare and were evaluated in vivo in mice for micro-CT of full body vasculature, where following intravenous injection, TaOx NCs demonstrate high CT contrast, circulation in blood for ~ 3 h, and eventual accumulation in RES organs; and following injection locally in the mammary gland, where the full ductal tree structure can be clearly delineated. Partially hydrophilic NCs were encapsulated within mesoporous silica nanoparticles (MSNPs; TaOx@MSNPs) and hydrophobic NCs were encapsulated within poly(lactic-co-glycolic acid) (PLGA; TaOx@PLGA) NPs, serving as potential CT-imagable drug delivery vehicles. Bolus intramuscular injections of TaOx@PLGA NPs and TaOx@MSNPs to mimic the accumulation of NPs at a tumor site produce high signal enhancement in mice. In vitro studies on bare NCs and formuated NPs demonstrate high cytocompatibility and low dissolution of TaOx. This work solidifies that TaOx-based NPs are versatile contrast agents for CT.

Trends in Nanotechnology for in vivo Cancer Diagnosis: Products and Patents

2020 ◽  
Vol 26 (18) ◽  
pp. 2167-2181
Author(s):  
Tatielle do Nascimento ◽  
Melanie Tavares ◽  
Mariana S.S.B. Monteiro ◽  
Ralph Santos-Oliveira ◽  
Adriane R. Todeschini ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Quantum Dots ◽  
Magnetic Resonance ◽  
Metal Nanoparticles ◽  
Cancer Diagnosis ◽  
Imaging Techniques ◽  
Tumor Detection ◽  
Abnormal Growth ◽  
Pharmaceutical Nanotechnology

Background: Cancer is a set of diseases formed by abnormal growth of cells leading to the formation of the tumor. The diagnosis can be made through symptoms’ evaluation or imaging tests, however, the techniques are limited and the tumor detection may be late. Thus, pharmaceutical nanotechnology has emerged to optimize the cancer diagnosis through nanostructured contrast agent’s development. Objective: This review aims to identify commercialized nanomedicines and patents for cancer diagnosis. Methods: The databases used for scientific articles research were Pubmed, Science Direct, Scielo and Lilacs. Research on companies’ websites and articles for the recognition of commercial nanomedicines was performed. The Derwent tool was applied for patent research. Results: This article aimed to research on nanosystems based on nanoparticles, dendrimers, liposomes, composites and quantum dots, associated to imaging techniques. Commercialized products based on metal and composite nanoparticles, associated with magnetic resonance and computed tomography, have been observed. The research conducted through Derwent tool displayed a small number of patents using nanotechnology for cancer diagnosis. Among these patents, the most significant number was related to the use of systems based on metal nanoparticles, composites and quantum dots. Conclusion: Although few systems are found in the market and patented, nanotechnology appears as a promising field for the development of new nanosystems in order to optimize and accelerate the cancer diagnosis.

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