Low Skeletal Muscle Mass Is An Independent Risk Factor For Arterial Stiffness: The Nagahama Study

Abstract Background Low muscle mass (myopenia) is frequent in rheumatoid arthritis (RA) patients with a long-disease duration. Although, the use of combined therapy with conventional synthetic DMARDs (csDMARDs) is one of the main strategies observed in these patients; there is a lack of information if the failure to these therapies increases the risk of myopenia. Objective: To evaluate whether the treatment failure to combined therapy with conventional synthetic DMARDs is an independent risk factor for low skeletal muscle mass in women with RA. Methods This cross-sectional study compared 277 women with RA (cases) and 237 women from non-rheumatic population (controls). In RA patients, we assessed clinical, epidemiological, and therapeutic variables (identifying treatment failure to combined therapy with csDMARDs. The skeletal muscle index (SMI) was estimated by DXA. Low skeletal muscle mass was defined as SMI<5.45 kg/m2. Multivariate logistic regression analyses were used to a) evaluate whether RA is an independent risk factor of myopenia in comparison with non-rheumatic population and b) identify if treatment failure with csDMARDs is an independent risk factor of myopenia in RA. Results RA patients had a higher prevalence of low skeletal muscle mass than controls (27.8% vs. 15.6%, p=0.001). After adjusting for other factors, RA patients had higher risk of low skeletal muscle mass than controls (OR: 2.7, 95%CI:1.7 to 4.5). Risk factors of low muscle mass in RA patients; were: menopause (OR: 2.3, 95%CI: 1.2 to 4.6, p=0.02) and a failure to combined therapy with csDMARDs (OR: 2.4, 95%CI: 1.10 to 5.81, p=0.03). Conclusions Rheumatoid arthritis is associated with an increased risk of myopenia. Treatment Failure with conventional-synthetic DMARDs constitutes a strong risk factor for deteriorated skeletal muscle mass.

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The BMI and skeletal muscle mass as a risk factor of carotid atherosclerosis in patients with type 2 diabetes

Endocrine Abstracts ◽

10.1530/endoabs.56.gp73 ◽

2018 ◽

Author(s):

Se-Hwa Kim ◽

Soo-Kyung Kim ◽

Young-Ju Choi ◽

Seok-Won Park ◽

Eun-Jig Lee ◽

...

Keyword(s):

Type 2 Diabetes ◽

Skeletal Muscle ◽

Risk Factor ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Carotid Atherosclerosis

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Augmentation Index Is Inversely Associated with Skeletal Muscle Mass, Muscle Strength, and Anaerobic Power in Young Male Adults: A Preliminary Study

Applied Sciences ◽

10.3390/app11073146 ◽

2021 ◽

Vol 11 (7) ◽

pp. 3146

Author(s):

Dongmin Lee ◽

Kyengho Byun ◽

Moon-Hyon Hwang ◽

Sewon Lee

Keyword(s):

Skeletal Muscle ◽

Muscle Strength ◽

Arterial Stiffness ◽

Muscle Mass ◽

Muscular Strength ◽

Skeletal Muscle Mass ◽

Augmentation Index ◽

Anaerobic Power ◽

Negatively Associated ◽

Increased Risk

Arterial stiffness is associated with an increased risk of cardiovascular disease. Previous studies have shown that there is a negative correlation between arterial stiffness and variables such as skeletal muscle mass, muscular strength, and anaerobic power in older individuals. However, little research has been undertaken on relationships in healthy young adults. This study presents a preliminary research that investigates the association between arterial stiffness and muscular factors in healthy male college students. Twenty-three healthy young males (23.9 ± 0.5 years) participated in the study. The participants visited the laboratory, and variables including body composition, blood pressure, arterial stiffness, blood parameters, grip strength, and anaerobic power were measured. Measurements of augmentation index (AIx) and brachial-ankle pulse wave velocity (baPWV) were performed to determine arterial stiffness. There were significant positive correlations among skeletal muscle mass, muscle strength, and anaerobic power in healthy young adult males. AIx was negatively associated with a skeletal muscle mass (r = −0.785, p < 0.01), muscular strength (r = −0.500, p < 0.05), and anaerobic power (r = −0.469, p < 0.05), respectively. Likewise, AIx@75 corrected with a heart rate of 75 was negatively associated with skeletal muscle mass (r = −0.738, p < 0.01), muscular strength (r = −0.461, p < 0.05), and anaerobic power (r = −0.420, p < 0.05) respectively. However, the baPWV showed no correlation with all muscular factors. Our findings suggest that maintaining high levels of skeletal muscle mass, muscular strength, and anaerobic power from relatively young age may lower AIx.

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Relationship between Muscle Mass and Non-Alcoholic Fatty Liver Disease

Biology ◽

10.3390/biology10020122 ◽

2021 ◽

Vol 10 (2) ◽

pp. 122

Author(s):

Jun-Hyuk Lee ◽

Hye-Sun Lee ◽

Byoung-Kwon Lee ◽

Yu-Jin Kwon ◽

Ji-Won Lee

Keyword(s):

Skeletal Muscle ◽

Risk Factor ◽

Liver Disease ◽

Fatty Liver ◽

Muscle Mass ◽

Fatty Liver Disease ◽

Skeletal Muscle Mass ◽

Liver Fat ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Although sarcopenia is known to be a risk factor for non-alcoholic fatty liver disease (NAFLD), whether NAFLD is a risk factor for the development of sarcopenia is not clear. We investigated relationships between NAFLD and low skeletal muscle mass index (LSMI) using three different datasets. Participants were classified into LSMI and normal groups. LSMI was defined as a body mass index (BMI)-adjusted appendicular skeletal muscle mass <0.789 in men and <0.512 in women or as the sex-specific lowest quintile of BMI-adjusted total skeletal muscle mass. NAFLD was determined according to NAFLD liver fat score or abdominal ultrasonography. The NAFLD groups showed a higher hazard ratios (HRs) with 95% confidence intervals (CIs) for LSMI than the normal groups (HRs = 1.21, 95% CIs = 1.05–1.40). The LSMI groups also showed a higher HRs with 95% CIs for NAFLD than normal groups (HRs = 1.56, 95% CIs = 1.38–1.78). Participants with NAFLD had consistently less skeletal muscle mass over 12 years of follow-up. In conclusion, LSMI and NAFLD showed a relationship. Maintaining muscle mass should be emphasized in the management of NAFLD.

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Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: The Korean Sarcopenic Obesity Study (KSOS)

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2011.06.013 ◽

2011 ◽

Vol 93 (2) ◽

pp. 285-291 ◽

Cited By ~ 86

Author(s):

Tae Nyun Kim ◽

Man Sik Park ◽

Kang Il Lim ◽

Sae Jeong Yang ◽

Hye Jin Yoo ◽

...

Keyword(s):

Skeletal Muscle ◽

Metabolic Syndrome ◽

Arterial Stiffness ◽

Muscle Mass ◽

Visceral Fat ◽

Skeletal Muscle Mass ◽

Area Ratio ◽

Sarcopenic Obesity ◽

Visceral Fat Area

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Low Skeletal Muscle Mass Is a Risk Factor for Aspiration Pneumonia During Chemoradiotherapy

The Laryngoscope ◽

10.1002/lary.29165 ◽

2020 ◽

Author(s):

Kazuhira Endo ◽

Takayoshi Ueno ◽

Nobuyuki Hirai ◽

Takeshi Komori ◽

Yosuke Nakanishi ◽

...

Keyword(s):

Skeletal Muscle ◽

Risk Factor ◽

Muscle Mass ◽

Aspiration Pneumonia ◽

Skeletal Muscle Mass

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Gender-specific associations of skeletal muscle mass and arterial stiffness among peritoneal dialysis patients

Scientific Reports ◽

10.1038/s41598-018-19710-6 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 4

Author(s):

Xinhui Liu ◽

Xunhua Zheng ◽

Chunyan Yi ◽

Juan Wu ◽

Hongjian Ye ◽

...

Keyword(s):

Skeletal Muscle ◽

Peritoneal Dialysis ◽

Arterial Stiffness ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Dialysis Patients ◽

Gender Specific

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In Response to Low Skeletal Muscle Mass Is a Risk Factor for Aspiration Pneumonia

The Laryngoscope ◽

10.1002/lary.29792 ◽

2021 ◽

Author(s):

Kazuhira Endo ◽

Takayoshi Ueno ◽

Nobuyuki Hirai ◽

Takeshi Komori ◽

Yosuke Nakanishi ◽

...

Keyword(s):

Skeletal Muscle ◽

Risk Factor ◽

Muscle Mass ◽

Aspiration Pneumonia ◽

Skeletal Muscle Mass

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1244Associations of endothelial function, arterial elasticity, and arterial stiffness with adiponectin and skeletal muscle mass

International Journal of Epidemiology ◽

10.1093/ije/dyab168.011 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Andrew O. Agbaje ◽

Alan R. Barker ◽

Tomi-Pekka Tuomainen

Keyword(s):

Skeletal Muscle ◽

Arterial Stiffness ◽

Endothelial Function ◽

Muscle Mass ◽

Fat Mass ◽

Brachial Artery ◽

Skeletal Muscle Mass ◽

Percentage Change ◽

Arterial Elasticity ◽

Total Fat

Abstract Background A temporal association where better arterial function and structure predicts adiponectin level and skeletal muscle mass during childhood remains uninvestigated. Methods We studied 5566 children and adolescents (51% girls) aged 9-11 years from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, Bristol, UK. Brachial artery endothelial function was determined using flow-mediated dilation (FMD), expressed as the percentage change in diameter from baseline after reactive hyperemia; arterial elasticity as distensibility coefficient (DC) expressed in mean percentage change in cross-sectional area relative to blood pressure (BP); and arterial stiffness by carotid to radial pulse wave velocity (crPWV). Skeletal muscle mass and total fat mass were assessed by dual-energy Xray absorptiometry. We conducted multivariable linear regressions with Sidak correction and adjusted for age, sex, total fat mass, cardiorespiratory fitness, pubertal status, brachial artery diameter, systolic BP, low-density lipoprotein cholesterol, mother’s social-economic class, and time (years) between the measurement of predictors and outcomes. Results FMD (β [95% CI]) = (0.027 [0.007 to 0.047]; P = 0.009) and DC (0.229 [0.088 to 0.369]; P = 0.001) were directly associated with skeletal muscle mass. FMD had a borderline inverse association with adiponectin (-0.004 [-0.008 to < 0.0001]; P = 0.056). crPWV was unrelated to adiponectin and skeletal muscle mass, while DC was not associated with adiponectin. Conclusions Better endothelial function and arterial elasticity were associated with higher skeletal muscle mass while arterial stiffness was unrelated to adiponectin and lean mass. Key message Healthy arterial function and structure may enhance muscle growth in children.

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