Assessment of plasma ceramides as predictor for preclinical atherosclerosis

2021 ◽  
Vol 331 ◽  
pp. e157
Author(s):  
P. Mishra
Keyword(s):  
Preclinical Atherosclerosis

scholarly journals Impact of Physical Activity on Preclinical Atherosclerosis in Premenopausal Women

2018 ◽  
Vol 53 ◽  
pp. 279
Author(s):  
Anna Vittoria Mattioli ◽  
Francesca Coppi ◽  
Matteo Ballerini Puviani ◽  
Alberto Farinetti
Keyword(s):  
Physical Activity ◽  
Premenopausal Women ◽  
Preclinical Atherosclerosis

scholarly journals Relation Between Preclinical Atherosclerosis and Venous Thromboembolism in Patients With Thrombophilias – Longitudinal Study

2014 ◽  
pp. S403-S409 ◽  
Author(s):  
O. AUZKÝ ◽  
R. DEMBOVSKÁ ◽  
J. MRÁZKOVÁ ◽  
Š. NOVÁKOVÁ ◽  
L. PAGÁČOVÁ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Longitudinal Study ◽  
Venous Thromboembolism ◽  
Waist Circumference ◽  
Systolic Blood Pressure ◽  
Body Mass ◽  
History Of ◽  
Preclinical Atherosclerosis

Preclinical atherosclerosis may represent a risk factor for venous thromboembolism (VTE). In longitudinal study we followed longitudinally 96 patients (32 men) with thrombophilias with (n=51) and without (n=45) history of VTE. In both groups we studied the changes of preclinical atherosclerosis at peripherally located arteries detected by ultrasound. In addition, we assessed changes in selected risk factors of atherosclerosis. During the mean follow-up of 56.0±7.62 months we did not find significant change in preclinical atherosclerosis defined as Belcaro score in either group (–3 % in the VTE group vs 0 % in non VTE group). Significant increase in body mass index (1.03±1.98 kg*m-2, resp. 1.21±1.67 kg*m-2, p<0.01) and non-significant increase in systolic blood pressure were detected in both groups. Waist circumference increased significantly only in patients without VTE (4.11±7.84 cm, p<0.05). No differences in changes of risk factors under study between both groups were detected. In summary, patients with thrombophilia and history of VTE showed no evidence of greater progression of atherosclerosis or increase in traditional risk factors of atherosclerosis than patients with thrombophilia without history of VTE. Unfavorable changes of body mass index, waist circumference and systolic blood pressure were detected in both groups during study period.

scholarly journals Repeated Episodes of Hypoglycemia as a Potential Aggravating Factor for Preclinical Atherosclerosis in Subjects With Type 1 Diabetes

Diabetes Care ◽  
2010 ◽  
Vol 34 (1) ◽  
pp. 198-203 ◽  
Author(s):  
M. Gimenez ◽  
R. Gilabert ◽  
J. Monteagudo ◽  
A. Alonso ◽  
R. Casamitjana ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Preclinical Atherosclerosis

Steno type 1 risk engine and preclinical atherosclerosis in Mediterranean individuals with type 1 diabetes

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
C. Viñals ◽  
I. Conget ◽  
A. Pané ◽  
L. Boswell ◽  
V. Perea ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Risk Engine ◽  
Preclinical Atherosclerosis

Associations between dimensional personality measures and preclinical atherosclerosis: The cardiovascular risk in Young Finns study

2012 ◽  
Vol 72 (5) ◽  
pp. 336-343 ◽  
Author(s):  
Tom Rosenström ◽  
Markus Jokela ◽  
Claude Robert Cloninger ◽  
Mirka Hintsanen ◽  
Markus Juonala ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Personality Measures ◽  
Preclinical Atherosclerosis ◽  
Young Finns Study

Assessment of Preclinical Atherosclerosis in Patients with Ankylosing Spondylitis

2012 ◽  
Vol 39 (2) ◽  
pp. 322-326 ◽  
Author(s):  
WAFA HAMDI ◽  
MOUNA CHELLI BOUAZIZ ◽  
IMEN ZOUCH ◽  
MOHAMED MEHDI GHANNOUCHI ◽  
MANEL HAOUEL ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Structural Damage ◽  
Activity Index ◽  
Age At Onset ◽  
Disease Activity Index ◽  
Mobility Limitations ◽  
Increased Risk ◽  
Preclinical Atherosclerosis

Objective.Epidemiological studies recently confirmed the increased risk of vascular morbidity and mortality during ankylosing spondylitis (AS). Increase of intima-media thickness (IMT) of the common carotid artery is a useful and noninvasive marker of preclinical atherosclerosis. The aim of our study was to compare IMT in patients with AS with matched controls and to determine risk factors of atherosclerosis related to AS.Methods.We performed a prospective study of 60 consecutive patients meeting modified New York criteria for AS, compared to 60 controls matched for age and sex. Disease-specific measures were determined. Measurement of IMT was performed by the same radiologist using the same machine and probe in right and left common carotid arteries, and the average of the 2 measurements was considered.Results.In total 48 male and 12 female patients were recruited, and 60 corresponding controls; mean age was 36 ± 11 years. We found significantly increased IMT in the AS group (0.51 ± 0.12 mm) compared with controls (0.39 ± 0.09 mm; p = 0.001). After adjustment for confounding factors, increased IMT was still present (p = 0.003). Age at onset of AS (p = 0.001), Bath AS Disease Activity Index (p = 0.002), AS Disease Activity Score (ASDAS) erythrocyte sedimentation rate (ESR; p = 0.047), ASDAS C-reactive protein (CRP; p = 0.012), Bath AS Functional Index (p = 0.008), global spine visual analog scale for pain (p = 0.000), Schober index (p = 0.039), Bath AS Metrology Index (p = 0.028), modified Stoke Ankylosing Spondylitis Spine Score (p = 0.035), and high ESR (p = 0.001) and CRP (p = 0.000) were correlated with high IMT in patients with AS. Otherwise, status of arthritis (p = 0.442), enthesitis (p = 0.482), and HLA-B27 (p = 0.528) seemed to have no effect on IMT.Conclusion.AS is associated with an increased risk of atherosclerosis independent of traditional risk factors. Disease activity, functional and mobility limitations, structural damage, and inflammation are the most incriminated risk factors.

Relationship of serum osteoprotegerin with arterial stiffness, preclinical atherosclerosis, and disease activity in patients with ankylosing spondylitis

2016 ◽  
Vol 35 (9) ◽  
pp. 2235-2241 ◽  
Author(s):  
Münevver Serdaroğlu Beyazal ◽  
Turan Erdoğan ◽  
Aysegül Kücükali Türkyılmaz ◽  
Gül Devrimsel ◽  
Medine Cumhur Cüre ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Arterial Stiffness ◽  
Disease Activity ◽  
Relationship Of ◽  
Preclinical Atherosclerosis

Preclinical Atherosclerosis in Patients with Prolactinoma

2014 ◽  
Vol 20 (5) ◽  
pp. 447-451 ◽  
Author(s):  
Muyesser Arslan ◽  
Oya Topaloglu ◽  
Mustafa Sahin ◽  
Esra Tutal ◽  
Askin Gungunes ◽  
...  
Keyword(s):  
Preclinical Atherosclerosis

scholarly journals Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy

2020 ◽  
Vol 21 (23) ◽  
pp. 9244
Author(s):  
Fabiana Baganha ◽  
Laila Ritsma ◽  
Paul H. A. Quax ◽  
Margreet R. de Vries
Keyword(s):  
Intravital Microscopy ◽  
Neck Region ◽  
Dynamic Processes ◽  
Pathological State ◽  
Vein Grafts ◽  
Two Photon ◽  
Atherosclerotic Lesions ◽  
Microvessel Permeability ◽  
Set Up ◽  
Preclinical Atherosclerosis

Plaque angiogenesis and plaque hemorrhage are major players in the destabilization and rupture of atherosclerotic lesions. As these are dynamic processes, imaging of plaque angiogenesis, especially the integrity or leakiness of angiogenic vessels, can be an extremely useful tool in the studies on atherosclerosis pathophysiology. Visualizing plaque microvessels in 3D would enable us to study the architecture and permeability of adventitial and intimal plaque microvessels in advanced atherosclerotic lesions. We hypothesized that a comparison of the vascular permeability between healthy continuous and fenestrated as well as diseased leaky microvessels, would allow us to evaluate plaque microvessel leakiness. We developed and validated a two photon intravital microscopy (2P-IVM) method to assess the leakiness of plaque microvessels in murine atherosclerosis-prone ApoE3*Leiden vein grafts based on the quantification of fluorescent-dextrans extravasation in real-time. We describe a novel 2P-IVM set up to study vessels in the neck region of living mice. We show that microvessels in vein graft lesions are in their pathological state more permeable in comparison with healthy continuous and fenestrated microvessels. This 2P-IVM method is a promising approach to assess plaque angiogenesis and leakiness. Moreover, this method is an important advancement to validate therapeutic angiogenic interventions in preclinical atherosclerosis models.

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