scholarly journals Impact of Physical Activity on Preclinical Atherosclerosis in Premenopausal Women

2018 ◽  
Vol 53 ◽  
pp. 279
Author(s):  
Anna Vittoria Mattioli ◽  
Francesca Coppi ◽  
Matteo Ballerini Puviani ◽  
Alberto Farinetti
Keyword(s):  
Physical Activity ◽  
Premenopausal Women ◽  
Preclinical Atherosclerosis

Sclerostin and Dickkopf-1 Characteristics According to Age and Physical Activity Levels in Premenopausal Women

2021 ◽  
Author(s):  
Pragya Sharma-Ghimire ◽  
Samuel Buchanan ◽  
Michael G Bemben ◽  
Allen Knehans ◽  
Jason Campbell ◽  
...  
Keyword(s):  
Physical Activity ◽  
Premenopausal Women ◽  
Activity Levels ◽  
Physical Activity Levels ◽  
Dickkopf 1

Abstract P254: Risk Factors For Venous Thromboembolism in a Cohort of French Women

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Martin Lajous ◽  
Laura Tondeur ◽  
Agnes Fournier ◽  
Francoise Clavel-Chapelon
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Venous Thromboembolism ◽  
Fruits And Vegetables ◽  
Smoking Status ◽  
Premenopausal Women ◽  
Prior History ◽  
Inverse Association ◽  
Vein Thrombosis

Background: There is controversy over whether cardiovascular disease and venous thromboembolism (VTE) share risk factors. Prospective information on risk factors for VTE in otherwise healthy individuals is limited. Methods and Results We evaluated the relation between known risk factors for cardiovascular disease and incidence of VTE among 65,272 French women in the E3N prospective cohort study with no prior history of VTE and who were free of cardiovascular disease or cancer in 1993. All information was self-reported via mailed questionnaires and diet and physical activity were assessed using previously validated instruments. Between 1993 and 2007, 766 cases of deep vein thrombosis or pulmonary embolism were first identified through self-reports and validated using medical records and information from treating physicians. Cases were considered valid if the diagnosis was based on an imaging procedure. We evaluated the following risk factors: education, menopause, postmenopausal hormone use, treated hypercholesterolemia and hypertension, diabetes, body mass index (BMI), physical activity, smoking status and intake of alcohol, red meat, fish, fruits and vegetables, fiber and coffee. In a multivariable model with age as the time scale, we found that, compared to women with a BMI <22 kg/m2, the HR (95%CI) was 1.35 (1.14, 1.60) for 22–24.9 kg/m2, 2.11 (1.73, 2.57) for 25–29.9 kg/m2 and 2.88 (2.08, 3.98) for ≥30 kg/m2 and the p-trend was <0.0001. Menopause was found to be inversely associated with VTE risk [HR=0.60 (95%CI 0.45–0.80); postmenopausal vs. premenopausal women]. In analyses restricted to postmenopausal women, relative to never users current use of postmenopausal hormones was significantly associated to VTE risk [HR=1.44 (95%CI 1.18–1.74)]. No significant association was found with dietary and other cardiovascular risk factors. Conclusion In this large prospective study only some risk factors for cardiovascular disease were associated to VTE incidence. We observed a strong inverse association between menopause and VTE.

Physical activity prevents bone loss in premenopausal women with rheumatoid arthritis: a cohort study

2008 ◽  
Vol 28 (10) ◽  
pp. 1001-1007 ◽  
Author(s):  
Tatiana Freitas Tourinho ◽  
Edison Capp ◽  
João Carlos Brenol ◽  
Airton Stein
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity ◽  
Cohort Study ◽  
Bone Loss ◽  
Premenopausal Women

scholarly journals Relationship between insulin sensitivity and menstrual cycle is modified by BMI, fitness and physical activity in NHANES

2021 ◽  
Author(s):  
Kirstin A MacGregor ◽  
Iain J Gallagher ◽  
Colin N Moran
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Menstrual Cycle ◽  
Cardiorespiratory Fitness ◽  
Resistance Index ◽  
Premenopausal Women ◽  
Category Membership ◽  
Insulin Resistance Index ◽  
Homeostatic Model

Abstract Context There is evidence demonstrating variation in insulin sensitivity across the menstrual cycle. However, to date, research has yielded inconsistent results. Objective This study investigated variation in insulin sensitivity across the menstrual cycle and associations with BMI, physical activity and cardiorespiratory fitness. Design Data from 1906 premenopausal women in NHANES cycles 1999-2006 were analysed. Main outcome measures Menstrual cycle day was assessed using questionnaire responses recording days since last period. Rhythmic variation of plasma glucose, triglyceride and insulin, homeostatic model of insulin resistance (HOMA-IR) and adipose tissue insulin resistance index (ADIPO-IR) across the menstrual cycle were analysed using cosinor rhythmometry. Participants were assigned low or high categories of BMI, physical activity and cardiorespiratory fitness and category membership included in cosinor models as covariates. Results Rhythmicity was demonstrated by a significant cosine fit for glucose (p= 0.014) but not triglyceride (p= 0.369), insulin (p= 0.470), HOMA-IR (p=0.461) and ADIPO-IR (p= 0.335). When covariates were included, rhythmicity was observed when adjusting for: 1. BMI: glucose (p&lt; 0.001), triglyceride (p&lt; 0.001), insulin (p&lt; 0.001), HOMA-IR (p&lt; 0.001) and ADIPO-IR (p&lt; 0.001); 2. Physical activity: glucose (p&lt; 0.001), triglyceride (p= 0.006) and ADIPO-IR (p= 0.038); 3. Cardiorespiratory fitness: triglyceride (p= 0.041), insulin (p= 0.002), HOMA-IR (p= 0.004) and ADIPO-IR (p= 0.004). Triglyceride amplitude, but not acrophase, was greater in the high physical activity category compared to low (p=0.018). Conclusions Rhythmicity in insulin sensitivity and associated metabolites across the menstrual cycle are modified by BMI, physical activity and cardiorespiratory fitness.

scholarly journals Physical activity in premenopausal women with asymptomatic peripheral arterial disease

2018 ◽  
Vol 19 (11) ◽  
pp. 677-680 ◽  
Author(s):  
Anna Vittoria Mattioli ◽  
Francesca Coppi ◽  
Mario Migaldi ◽  
Alberto Farinetti
Keyword(s):  
Physical Activity ◽  
Peripheral Arterial Disease ◽  
Premenopausal Women ◽  
Arterial Disease ◽  
Peripheral Arterial

Determinants of insulin-stimulated glucose disposal in middle-aged, premenopausal women

2001 ◽  
Vol 281 (1) ◽  
pp. E113-E121 ◽  
Author(s):  
Michael J. Toth ◽  
Cynthia K. Sites ◽  
William T. Cefalu ◽  
Dwight E. Matthews ◽  
Eric T. Poehlman
Keyword(s):  
Physical Activity ◽  
Maximal Oxygen Consumption ◽  
Premenopausal Women ◽  
Abdominal Fat ◽  
Fat Free Mass ◽  
Thigh Muscle ◽  
Whole Body ◽  
Glucose Disposal ◽  
Statistical Control ◽  
Regional Adiposity

Controversy exists regarding the relative importance of adiposity, physical fitness, and physical activity in the regulation of insulin-stimulated glucose disposal. To address this issue, we measured insulin-stimulated glucose disposal [mg · kg fat-free mass (FFM)−1 · min−1; oxidative and nonoxidative components] in 45 nondiabetic, nonobese, premenopausal women (mean ± SD; 47 ± 3 yr) by use of hyperinsulinemic euglycemic clamp (40 mU · m−2 · min−1) and [6,6-2H2]glucose dilution techniques. We also measured body composition, abdominal fat distribution, thigh muscle fat content, maximal oxygen consumption (V˙o 2 max), and physical activity energy expenditure (2H2 18O kinetics) as possible correlates of glucose disposal.V˙o 2 max was the strongest correlate of glucose disposal ( r = 0.63, P < 0.01), whereas whole body and abdominal adiposity showed modest associations (range of r values from −0.32 to −0.46, P< 0.05 to P < 0.01). A similar pattern of correlations was observed for nonoxidative glucose disposal. None of the variables measured correlated with oxidative glucose disposal. The relationship of V˙o 2 max to glucose disposal persisted after statistical control for FFM, percent body fat, and intra-abdominal fat ( r = 0.40, P < 0.01). In contrast, correlations of total and regional adiposity measures to insulin sensitivity were no longer significant after statistical adjustment for V˙o 2 max.V˙o 2 max was the only variable to enter stepwise regression models as a significant predictor of total and nonoxidative glucose disposal. Our results highlight the importance ofV˙o 2 max as a determinant of glucose disposal and suggest that it may be a stronger determinant of variation in glucose disposal than total and regional adiposity in nonobese, nondiabetic, premenopausal women.

scholarly journals Oxidative stress in relation to diet and physical activity among premenopausal women

2016 ◽  
Vol 116 (8) ◽  
pp. 1416-1424 ◽  
Author(s):  
Chelsea Anderson ◽  
Ginger L. Milne ◽  
Dale P. Sandler ◽  
Hazel B. Nichols
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Fatty Acids ◽  
Alcohol Consumption ◽  
Dietary Fat ◽  
Premenopausal Women ◽  
Dietary Intakes ◽  
Linear Regression Models ◽  
Diet And Physical Activity ◽  
Long Chain

AbstractHigher levels of oxidative stress, as measured by F2-isoprostanes, have been associated with chronic diseases such as CVD and some cancers. Improvements in diet and physical activity may help reduce oxidative stress; however, previous studies regarding associations between lifestyle factors and F2-isoprostane concentrations have been inconsistent. The aim of this cross-sectional study was to investigate whether physical activity and intakes of fruits/vegetables, antioxidant nutrients, dietary fat subgroups and alcohol are associated with concentrations of F2-isoprostane and the major F2-isoprostane metabolite. Urinary F2-isoprostane and its metabolite were measured in urine samples collected at enrolment from 912 premenopausal women (aged 35–54 years) participating in the Sister Study. Physical activity, alcohol consumption and dietary intakes were self-reported via questionnaires. With adjustment for potential confounders, the geometric means of F2-isoprostane and its metabolite were calculated according to quartiles of dietary intakes, alcohol consumption and physical activity, and linear regression models were used to evaluate trends. Significant inverse associations were found between F2-isoprostane and/or its metabolite and physical activity, vegetables, fruits, vitamin C, α-carotene, vitamin E, β-carotene, vitamin A, Se, lutein+zeaxanthin and long-chain n-3 fatty acids. Although trans fats were positively associated with both F2-isoprostane and its metabolite, other dietary fat subgroups including SFA, n-6 fatty acids, n-3 fatty acids, MUFA, PUFA, short-chain n-3 fatty acids, long-chain n-3 fatty acids and total fat were not associated with either F2-isoprostane or its metabolite. Our findings suggest that lower intake of antioxidant nutrients and higher intake of trans fats may be associated with greater oxidative stress among premenopausal women.

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