scholarly journals Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression

2015 ◽  
Vol 1852 (9) ◽  
pp. 1989-1999 ◽  
Author(s):  
Suman Dutta ◽  
Onrapak Reamtong ◽  
Wittaya Panvongsa ◽  
Sarunya Kitdumrongthum ◽  
Keatdamrong Janpipatkul ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Potential Role ◽  
Oncogenic Protein

Acid ceramidase, a double-edged sword in cancer aggression: A minireview

2020 ◽  
Vol 20 ◽  
Author(s):  
Helen Shiphrah Vethakanraj ◽  
Niveditha Chandrasekaran ◽  
Ashok Kumar Sekar
Keyword(s):  
Cell Fate ◽  
Cancer Progression ◽  
Potential Role ◽  
Tumour Progression ◽  
Acid Ceramidase ◽  
The Core ◽  
The Past ◽  
Sphingosine 1 Phosphate ◽  
Key Enzyme

: Acid ceramidase (AC), the key enzyme of the ceramide metabolic pathway hydrolyzes pro-apoptotic ceramide to sphingosine, which by the action of sphingosine-1-kinase is metabolized to mitogenic sphingosine-1-phosphate. The intracellular level of AC determines ceramide/sphingosine-1-phosphate rheostat which in turn decides the cell fate. The upregulated AC expression during cancerous condition acts as a “double-edged sword” by converting pro-apoptotic ceramide to anti-apoptotic sphingosine-1-phosphate, wherein on one end, the level of ceramide is decreased and on the other end, the level of sphingosine-1-phosphate is increased, thus altogether aggravating the cancer progression. In addition, cancer cells with upregulated AC expression exhibited increased cell proliferation, metastasis, chemoresistance, radioresistance and numerous strategies were developed in the past to effectively target the enzyme. Gene silencing and pharmacological inhibition of AC sensitized the resistant cells to chemo/radiotherapy thereby promoting cell death. The core objective of this review is to explore AC mediated tumour progression and the potential role of AC inhibitors in various cancer cell lines/models.

scholarly journals The potential role of RNA N6-methyladenosine in Cancer progression

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Tianyi Wang ◽  
Shan Kong ◽  
Mei Tao ◽  
Shaoqing Ju
Keyword(s):  
Cancer Progression ◽  
Potential Role

scholarly journals The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention

2016 ◽  
Vol 21 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Huzefa Vahora ◽  
Munawwar Ali Khan ◽  
Usama Alalami ◽  
Arif Hussain
Keyword(s):  
Nitric Oxide ◽  
Cancer Progression ◽  
Potential Role

scholarly journals m6A Demethylase FTO Promotes Tumor Progression via Regulation of Lipid Metabolism in Esophageal Cancer

2021 ◽  
Author(s):  
Xiaoran Duan ◽  
Li Yang ◽  
Liuya Wang ◽  
Qinghua Liu ◽  
Kai Zhang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Lipid Droplets ◽  
Target Gene ◽  
Potential Role ◽  
Theoretical Foundation ◽  
Rna Modification ◽  
Ec Cells

Abstract BackgroundEpitranscriptomics studies have contributed greatly to the development of research on human cancers. In recent years, N6-methyladenosine (m6A), an RNA modification on the N-6 position of adenosine, has been found to play a potential role in epigenetic regulation. Therefore, we aimed to evaluate the regulation of cancer progression properties by m6A. ResultsWe found that m6A demethylase fat mass and obesity-associated protein (FTO) was highly expressed in esophageal cancer (EC) stem-like cells, and that its level was also substantially increased in EC tissues, which was closely correlated with a poor prognosis in EC patients. FTO knockdown significantly inhibited the proliferation, invasion, stemness, and tumorigenicity of EC cells, whereas FTO overexpression promoted these characteristics. Furthermore, integrated transcriptome and meRIP-seq analyses revealed that HSD17B11 may be a target gene regulated by FTO. Moreover, FTO promoted the formation of lipid droplets in EC cells by enhancing HSD17B11 expression. Furthermore, depleting YTHDF1 increased the protein level of HSD17B11. ConclusionsThese data indicate that FTO may rely on the reading protein YTHDF1 to affect the translation pathway of the HSD17B11 gene to regulate the formation of lipid droplets in EC cells, thereby promoting the development of EC. The understanding of the role of epitranscriptomics in the development of EC will lay a theoretical foundation for seeking new anticancer therapies.

EP569 Potential role of PAI-1 in endometrial cancer progression and its regulation by epigenetic mechanisms

2019 ◽  
Author(s):  
J Marí-Alexandre ◽  
C Agababyan ◽  
P Pascual-Utiel ◽  
M Cubertorer-Navarro ◽  
J García-Oms ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Progression ◽  
Potential Role ◽  
Epigenetic Mechanisms ◽  
Pai 1

scholarly journals A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer

Membranes ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 312
Author(s):  
Mimmo Turano ◽  
Francesca Cammarota ◽  
Francesca Duraturo ◽  
Paola Izzo ◽  
Marina De Rosa
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Progression ◽  
Interleukin 6 ◽  
Potential Role ◽  
Target Cells ◽  
Sporadic Colorectal Cancer ◽  
Colon Cancer Progression ◽  
Interleukin 6 Receptor

Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise following somatic mutations, while about 10% are hereditary cancers caused by germline mutations in specific genes. Several factors, such as growth factors, cytokines, and genetic or epigenetic alterations in specific oncogenes or tumor-suppressor genes, play a role during the adenoma–carcinoma sequence. Recent studies have reported an increase in interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R) levels in the sera of patients affected by colon cancer that correlate with the tumor size, suggesting a potential role for IL-6 in colon cancer progression. IL-6 is a pleiotropic cytokine showing both pro- and anti-inflammatory roles. Two different types of IL-6 signaling are known. Classic IL-6 signaling involves the binding of IL-6 to its membrane receptor on the surfaces of target cells; alternatively, IL-6 binds to sIL-6R in a process called IL-6 trans-signaling. The activation of IL-6 trans-signaling by metalloproteinases has been described during colon cancer progression and metastasis, involving a shift from membrane-bound interleukin-6 receptor (IL-6R) expression on the tumor cell surface toward the release of soluble IL-6R. In this review, we aim to shed light on the role of IL-6 signaling pathway alterations in sporadic colorectal cancer and the development of familial polyposis syndrome. Furthermore, we evaluate the possible roles of IL-6 and IL-6R as biomarkers useful in disease follow-up and as potential targets for therapy, such as monoclonal antibodies against IL-6 or IL-6R, or a food-based approach against IL-6.

The microRNA-200 family: still much to discover

2016 ◽  
Vol 7 (5-6) ◽  
pp. 311-319 ◽  
Author(s):  
Daniel Senfter ◽  
Sibylle Madlener ◽  
Georg Krupitza ◽  
Robert M. Mader
Keyword(s):  
Cancer Progression ◽  
Epithelial To Mesenchymal Transition ◽  
Potential Role ◽  
Predictive Biomarker ◽  
Mesenchymal Transition ◽  
Cellular Processes ◽  
Active Regulation ◽  
The Individual ◽  
Open Issues

AbstractIn the last decade, microRNAs (miRs or miRNAs) became of great interest in cancer research due to their multifunctional and active regulation in a variety of vital cellular processes. In this review, we discuss the miR-200 family, which is composed of five members (miR-141, miR-200a/200b/200c and miR-429). Although being among the best investigated miRNAs in the field, there are still many open issues. Here, we describe the potential role of miR-200 as prognostic and/or predictive biomarker, its influence on motility and cell migration as well as its role in epithelial to mesenchymal transition (EMT) and metastasis formation in different tumour types. Recent studies also demonstrated the influence of miR-200 on drug resistance and described a correlation between miR-200 expression levels and overall survival of patients. Despite intense research in this field, the full role of the miR-200 family in cancer progression and metastasis is not completely understood and seems to differ between different tumour types and different cellular backgrounds. To elucidate these differences further, a finer characterisation of the role of the individual miRNA-200 family members is currently under investigation.

scholarly journals Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Enli Yang ◽  
Xuan Wang ◽  
Zhiyuan Gong ◽  
Miao Yu ◽  
Haiwei Wu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Potential Role ◽  
Tumor Development ◽  
Underlying Mechanism ◽  
Metabolic Reprogramming ◽  
Diagnosis And Prognosis ◽  
Energy Demands

Abstract Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands. Recently, extracellular vesicles (EVs) known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment (TME). Meanwhile, the TME is a highly heterogeneous ecosystem incorporating cancer cells, fibroblasts, adipocytes, endothelial cells, mesenchymal stem cells, and extracellular matrix. Accumulated evidence indicates that exosomes may transfer biologically functional molecules to the recipient cells, which facilitate cancer progression, angiogenesis, metastasis, drug resistance, and immunosuppression by reprogramming the metabolism of cancer cells and their surrounding stromal cells. In this review, we present the role of exosomes in the TME and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming. In addition, we will also discuss the potential role of exosomes targeting metabolic process as biomarkers for tumor diagnosis and prognosis, and exosomes-mediated metabolic reprogramming as potential targets for cancer therapy. Furthermore, a better understanding of the link between exosomes and metabolic reprogramming, and their impact on cancer progression, would provide novel insights for cancer prevention and treatment in the future.

scholarly journals The Role of Interleukin 17 in Tumour Proliferation, Angiogenesis, and Metastasis

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Bob Yang ◽  
Heechan Kang ◽  
Anthony Fung ◽  
Hailin Zhao ◽  
Tianlong Wang ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Potential Role ◽  
Chemotherapy Resistance ◽  
Cell Subset ◽  
World Health Organisation ◽  
World Health ◽  
Interleukin 17 ◽  
T Helper ◽  
Defence Reactions

With 7.6 million deaths globally, cancer according to the World Health Organisation is still one of the leading causes of death worldwide. Interleukin 17 (IL-17) is a cytokine produced by Th17 cells, a T helper cell subset developed from an activated CD4+ T-cell. Whilst the importance of IL-17 in human autoimmune disease, inflammation, and pathogen defence reactions has already been established, its potential role in cancer progression still needs to be updated. Interestingly studies have demonstrated that IL-17 plays an intricate role in the pathophysiology of cancer, from tumorigenesis, proliferation, angiogenesis, and metastasis, to adapting the tumour in its ability to confer upon itself both immune, and chemotherapy resistance. This review will look into IL-17 and summarise the current information and data on its role in the pathophysiology of cancer as well as its potential application in the overall management of the disease.

Sign in / Sign up

Export Citation Format

Share Document