Sumoylation regulates nuclear localization and function of zinc finger transcription factor ZIC3

The pannier (pnr) gene of Drosophila encodes a zinc-finger transcription factor of the GATA family and is involved in several developmental processes during embryonic and imaginal development. We report some novel aspects of the regulation and function of pnr during embryogenesis. Previous work has shown that pnr is activated by decapentaplegic (dpp) in early development, but we find that after stage 10, the roles are reversed and pnr becomes an upstream regulator of dpp. This function of pnr is necessary for the activation of the Dpp pathway in the epidermal cells implicated in dorsal closure and is not mediated by the JNK pathway, which is also necessary for Dpp activity in these cells. In addition, we show that pnr behaves as a selector-like gene in generating morphological diversity in the dorsoventral body axis. It is responsible for maintaining a subdivision of the dorsal half of the embryo into two distinct, dorsomedial and dorsolateral, regions, and also specifies the identity of the dorsomedial region. These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila.

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Identification of a Functional Nuclear Localization Signal Mediating Nuclear Import of the Zinc Finger Transcription Factor ZNF24

PLoS ONE ◽

10.1371/journal.pone.0079910 ◽

2013 ◽

Vol 8 (11) ◽

pp. e79910 ◽

Cited By ~ 6

Author(s):

Jian-Zhong Li ◽

Xia Chen ◽

Xue-Lian Gong ◽

Hong-Yuan Hu ◽

Duo Shi ◽

...

Keyword(s):

Transcription Factor ◽

Zinc Finger ◽

Nuclear Localization ◽

Nuclear Import ◽

Nuclear Localization Signal ◽

Zinc Finger Transcription Factor ◽

Localization Signal ◽

Functional Nuclear Localization Signal

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Expression and function of the zinc finger transcription factor Sp6–9 in the spider Parasteatoda tepidariorum

Development Genes and Evolution ◽

10.1007/s00427-017-0595-2 ◽

2017 ◽

Vol 227 (6) ◽

pp. 389-400 ◽

Cited By ~ 6

Author(s):

Tatiana Königsmann ◽

Natascha Turetzek ◽

Matthias Pechmann ◽

Nikola-Michael Prpic

Keyword(s):

Transcription Factor ◽

Zinc Finger ◽

Zinc Finger Transcription Factor ◽

Parasteatoda Tepidariorum ◽

And Function

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Characterization of the transactivation and nuclear localization functions of Pichia pastoris zinc finger transcription factor Mxr1p

Journal of Biological Chemistry ◽

10.1016/j.jbc.2021.101247 ◽

2021 ◽

Vol 297 (4) ◽

pp. 101247

Author(s):

Aditi Gupta ◽

Kamisetty Krishna Rao ◽

Umakant Sahu ◽

Pundi N. Rangarajan

Keyword(s):

Transcription Factor ◽

Pichia Pastoris ◽

Zinc Finger ◽

Nuclear Localization ◽

Zinc Finger Transcription Factor

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Faculty Opinions recommendation of The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1024248.290751 ◽

2005 ◽

Author(s):

Kyoko Hayakawa

Keyword(s):

Transcription Factor ◽

T Cell ◽

Zinc Finger ◽

Cell Lineage ◽

Cd8 T Cell ◽

Lineage Commitment ◽

Zinc Finger Transcription Factor

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Faculty Opinions recommendation of Phosphatidic acid interacts with a MYB transcription factor and regulates its nuclear localization and function in Arabidopsis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718218075.793491023 ◽

2014 ◽

Author(s):

Vitaly Citovsky ◽

Benoît Lacroix

Keyword(s):

Transcription Factor ◽

Phosphatidic Acid ◽

Nuclear Localization ◽

Myb Transcription Factor ◽

And Function

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Faculty Opinions recommendation of Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718215429.793489962 ◽

2014 ◽

Author(s):

Robert K Herman

Keyword(s):

Transcription Factor ◽

Caenorhabditis Elegans ◽

Zinc Finger ◽

Zinc Finger Transcription Factor

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Faculty Opinions recommendation of Regulation of Aluminum Resistance in Arabidopsis Involves the SUMOylation of the Zinc Finger Transcription Factor STOP1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738884406.793579957 ◽

2020 ◽

Author(s):

Ramón Serrano

Keyword(s):

Transcription Factor ◽

Zinc Finger ◽

Zinc Finger Transcription Factor ◽

Aluminum Resistance

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The apple C2H2-type zinc finger transcription factor MdZAT10 positively regulates JA-induced leaf senescence by interacting with MdBT2

Horticulture Research ◽

10.1038/s41438-021-00593-0 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Kuo Yang ◽

Jian-Ping An ◽

Chong-Yang Li ◽

Xue-Na Shen ◽

Ya-Jing Liu ◽

...

Keyword(s):

Mass Spectrometry ◽

Transcription Factor ◽

Liquid Chromatography ◽

Zinc Finger ◽

Leaf Senescence ◽

Transcriptional Activity ◽

Molecular Mechanisms ◽

Liquid Chromatography Mass Spectrometry ◽

Zinc Finger Transcription Factor ◽

Insight Into

AbstractJasmonic acid (JA) plays an important role in regulating leaf senescence. However, the molecular mechanisms of leaf senescence in apple (Malus domestica) remain elusive. In this study, we found that MdZAT10, a C2H2-type zinc finger transcription factor (TF) in apple, markedly accelerates leaf senescence and increases the expression of senescence-related genes. To explore how MdZAT10 promotes leaf senescence, we carried out liquid chromatography/mass spectrometry screening. We found that MdABI5 physically interacts with MdZAT10. MdABI5, an important positive regulator of leaf senescence, significantly accelerated leaf senescence in apple. MdZAT10 was found to enhance the transcriptional activity of MdABI5 for MdNYC1 and MdNYE1, thus accelerating leaf senescence. In addition, we found that MdZAT10 expression was induced by methyl jasmonate (MeJA), which accelerated JA-induced leaf senescence. We also found that the JA-responsive protein MdBT2 directly interacts with MdZAT10 and reduces its protein stability through ubiquitination and degradation, thereby delaying MdZAT10-mediated leaf senescence. Taken together, our results provide new insight into the mechanisms by which MdZAT10 positively regulates JA-induced leaf senescence in apple.

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