Shedding light on both ends: An update on analytical approaches for N- and C-terminomics

The effects of leakage and blockage on the acoustic performance of particle filters have been examined by using one-dimensional acoustic analysis and experimental methods. First, the transfer matrix of a filter system connected to inlet and outlet pipes with conical sections is measured using a two-load method. Then, the transfer matrix of a particle filter only is extracted from the experiments by applying inverse matrices of the conical sections. In the analytical approaches, the one-dimensional acoustic model for the leakage between the filter and the housing is developed. The predicted transmission loss shows a good agreement with the experimental results. Compared to the baseline, the leakage between the filter and housing increases transmission loss at a certain frequency and its harmonics. In addition, the transmission loss for the system with a partially blocked filter is measured. The blockage of the filter also increases the transmission loss at higher frequencies. For the simplicity of experiments to identify the leakage and blockage, the reflection coefficients at the inlet of the filter system have been measured using two different downstream conditions: open pipe and highly absorptive terminations. The experiments show that with highly absorptive terminations, it is easier to see the difference between the baseline and the defects.

Download Full-text

Monitoring of Petroleum-Related Environmental Contamination Using Fluorescence Fingerprinting

Water Practice & Technology ◽

10.2166/wpt.2006.029 ◽

2006 ◽

Vol 1 (2) ◽

Cited By ~ 1

Author(s):

P. Literathy ◽

M. Quinn

Keyword(s):

Environmental Contamination ◽

Statistical Evaluation ◽

Oil Pollution ◽

Emission Spectra ◽

Cost Effective ◽

Petroleum Products ◽

Danube River ◽

Aromatic Components ◽

Analytical Approaches

Petroleum and its refined products are considered the most complex contaminants frequently impacting the environment in significant quantities. They have heterogeneous chemical composition and alterations occur during environmental weathering. No single analytical method exists to characterize the petroleum-related environmental contamination. For monitoring, the analytical approaches include gravimetric, spectrometric and chromatographic methods having significant differences in their selectivity, sensitivity and cost-effectiveness. Recording fluorescence fingerprints of the cyclohexane extracts of the water, suspended solids, sediment or soil samples and applying appropriate statistical evaluation (e.g. by correlating the concatenated emission spectra of the fingerprints of the samples with arbitrary standards (e.g. petroleum products)), provides a powerful, cost-effective analytical tool for characterization of the type of oil pollution and detecting the most harmful aromatic components of the petroleum contaminated matrix. For monitoring purposes, the level of the contamination can be expressed as the equivalent concentration of an appropriate characteristic standard, based on the fluorescence intensities at the relevant characteristic wavelengths. These procedures are demonstrated in the monitoring of petroleum-related pollution in the water and suspended sediment in the Danube river basin

Download Full-text

Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data

Current Medicinal Chemistry ◽

10.2174/0929867327666200210144847 ◽

2020 ◽

Vol 28 (2) ◽

pp. 213-237 ◽

Cited By ~ 5

Author(s):

Andrea Mastinu ◽

Giovanni Ribaudo ◽

Alberto Ongaro ◽

Sara Anna Bonini ◽

Maurizio Memo ◽

...

Keyword(s):

In Silico ◽

Cannabis Sativa ◽

Therapeutic Potential ◽

The Novel ◽

In Silico Studies ◽

Computational Data ◽

Synthetic Approaches ◽

Analytical Approaches ◽

Yield Sensitivity ◽

Therapeutic Profile

: Cannabidiol (CBD) is a non-psychotropic phytocannabinoid which represents one of the constituents of the “phytocomplex” of Cannabis sativa. This natural compound is attracting growing interest since when CBD-based remedies and commercial products were marketed. This review aims to exhaustively address the extractive and analytical approaches that have been developed for the isolation and quantification of CBD. Recent updates on cutting-edge technologies were critically examined in terms of yield, sensitivity, flexibility and performances in general, and are reviewed alongside original representative results. As an add-on to currently available contributions in the literature, the evolution of the novel, efficient synthetic approaches for the preparation of CBD, a procedure which is appealing for the pharmaceutical industry, is also discussed. Moreover, with the increasing interest on the therapeutic potential of CBD and the limited understanding of the undergoing biochemical pathways, the reader will be updated about recent in silico studies on the molecular interactions of CBD towards several different targets attempting to fill this gap. Computational data retrieved from the literature have been integrated with novel in silico experiments, critically discussed to provide a comprehensive and updated overview on the undebatable potential of CBD and its therapeutic profile.

Download Full-text

Advances in the Chromatographic Separation and Determination of Bioactive Compounds for Assessing the Nutrient Profile of Nuts

Current Analytical Chemistry ◽

10.2174/1573411016999200729111951 ◽

2020 ◽

Vol 16 ◽

Author(s):

Natasa P. Kalogiouri ◽

Natalia Manousi ◽

Erwin Rosenberg ◽

George A. Zachariadis ◽

Victoria F. Samanidou

Keyword(s):

Fatty Acids ◽

Phenolic Compounds ◽

Bioactive Compounds ◽

High Performance ◽

Unsaturated Fatty Acids ◽

Nutritional Deficiencies ◽

Analytical Technique ◽

High Volatility ◽

Analytical Approaches

Background:: Nuts have been incorporated into guidelines for healthy eating since they contain considerable amounts of antioxidants and their effects are related to health benefits since they contribute to the prevention of nutritional deficiencies. The micronutrient characterization is based mainly on the determination of phenolics which is the most abundant class of bioactive compounds in nuts. Terpenes constitute another class of bioactive compounds that are present in nuts and show high volatility. The analysis of phenolic compounds and terpenes are very demanding tasks that require optimization of the chromatographic conditions to improve the separation of the components. Moreover, nuts are rich in unsaturated fatty acids and they are therefore considered as cardioprotective. Gas chromatography is the predominant instrumental analytical technique for the determination of derivatized fatty acids and terpenes in food matrices, while high performance liquid chromatography is currently the most popular technique for the determination of phenolic compounds Objective:: This review summarizes all the recent advances in the optimization of the chromatographic conditions for the determination of phenolic compounds, fatty acids and terpenes in nuts Conclusion:: The state-of-the art in the technology available is critically discussed, exploring new analytical approaches to reduce the time of analysis and improve the performance of the chromatographic systems in terms of precision, reproducibility, limits of detection and quantification and overall quality of the results

Download Full-text

Comparative Area Studies

10.1093/oso/9780190846374.003.0002 ◽

2018 ◽

Author(s):

Dirk Berg-Schlosser

Keyword(s):

Cold War ◽

Ivory Coast ◽

Qualitative Comparative Analysis ◽

The Other ◽

Area Studies ◽

International Context ◽

Recent Developments ◽

Cross Area Studies ◽

The Cold War ◽

Analytical Approaches

Area studies have undergone significant changes over the last two decades. They have been transformed from mostly descriptive accounts in the international context of the Cold War to theory-oriented and methodological analytical approaches. More recent comparative methods such as “Qualitative Comparative Analysis” (QCA) and related approaches, which are particularly suitable for medium N studies, have significantly contributed to this development. This essay discusses the epistemological background of this approach as well as recent developments. It provides two examples of current “cross area studies,” one concerned with successful democratic transformations across four regions (Africa, Eastern Europe, Latin America, and East Asia), the other with political participation in marginalized settlements in four countries (Brazil, Chile, Ivory Coast, Kenya) in a multilevel analysis. The conclusion points to the theoretical promises of this approach and its practical-political relevance.

Download Full-text

Design and Analysis for Quantitative Research in Music Education

10.1093/oso/9780199391905.001.0001 ◽

2018 ◽

Cited By ~ 2

Author(s):

Peter Miksza ◽

Kenneth Elpus

Keyword(s):

Education Research ◽

Data Analysis ◽

Music Education ◽

General Education ◽

Research Design ◽

Quantitative Research ◽

Traditional Design ◽

Design Type ◽

To Come ◽

Analytical Approaches

This book is an introduction to quantitative research design and data analysis presented in the context of music education scholarship. The book aims for readers to come away with a familiarity of prototypical research design possibilities as well as a fundamental understanding of data analysis techniques necessary for carrying out scientific inquiry. The book includes examples that demonstrate how the methodological and statistical concepts presented throughout can be applied to pertinent issues in music education. For the majority of Part I, the strategy is to present traditional design categories side by side with explanations of general analytical approaches for dealing with data yielded from each respective design type. Part II consists of chapters devoted to methodological and analytical approaches that have become common in related fields (e.g., psychology, sociology, general education research, educational policy) but are as yet not frequently exploited by music education researchers. Ultimately, this work is motivated by a desire to help scholars acquire the means to actualize their research curiosities and to contribute to the advancement of rigor in music education research throughout the profession at large.

Download Full-text