Can oxysterols work in anti-glioblastoma therapy? Model studies complemented with biological experiments

2021 ◽  
Vol 1863 (12) ◽  
pp. 183773
Author(s):  
Anita Wnętrzak ◽  
Agata Kubisiak ◽  
Anna Filiczkowska ◽  
Agnieszka Gonet-Surówka ◽  
Anna Chachaj-Brekiesz ◽  
...  
Keyword(s):  
2019 ◽  
Vol 28 (2) ◽  
pp. 69-78
Author(s):  
Diane M. Stutey ◽  
Darci E. Klein ◽  
Robert E. Wubbolding ◽  
Nikkie Dunnigan
Keyword(s):  

1995 ◽  
Vol 74 (03) ◽  
pp. 868-873 ◽  
Author(s):  
Silvana Arrighi ◽  
Roberta Rossi ◽  
Maria Giuseppina Borri ◽  
Vladimir Lesnikov ◽  
Marina Lesnikov ◽  
...  

SummaryTo improve the safety of plasma derived factor VIII (FVIII) concentrate, we introduced a final super heat treatment (100° C for 30 min) as additional virus inactivation step applied to a lyophilized, highly purified FVIII concentrate (100 IU/mg of proteins) already virus inactivated using the solvent/detergent (SID) method during the manufacturing process.The efficiency of the super heat treatment was demonstrated in inactivating two non-lipid enveloped viruses (Hepatitis A virus and Poliovirus 1). The loss of FVIII procoagulant activity during the super heat treatment was of about 15%, estimated both by clotting and chromogenic assays. No substantial changes were observed in physical, biochemical and immunological characteristics of the heat treated FVIII concentrate in comparison with those of the FVIII before heat treatment.


2014 ◽  
Vol 59 (4) ◽  
pp. 971-986 ◽  
Author(s):  
Krzysztof Tajduś

Abstract The paper presents the analysis of the phenomenon of horizontal displacement of surface induced by underground mining exploitation. In the initial part, the basic theories describing horizontal displacement are discussed, followed by three illustrative examples of underground exploitation in varied mining conditions. It is argued that center of gravity (COG) method presented in the paper, hypothesis of Awierszyn and model studies carried out in Strata Mechanics Research Institute of the Polish Academy of Sciences indicate the proportionality between vectors of horizontal displacement and the vector of surface slope. The differences practically relate to the value of proportionality coefficient B, whose estimated values in currently realized design projects for mining industry range between 0.23r to 0.42r for deep exploitations, whereas in the present article the values of 0.33r and 0.47r were obtained for two instances of shallow exploitation. Furthermore, observations on changes of horizontal displacement vectors with face advancement indicated the possibility of existence of COG zones above the mined-out field, which proved the conclusions of hitherto carried out research studies (Tajduś 2013).


1995 ◽  
Vol 32 (2) ◽  
pp. 141-148 ◽  
Author(s):  
I. S. Hansen ◽  
H. J. Vested ◽  
M. A. Latif

A modelling study of the hydrodynamics and spreading of wastewater from existing and future outfalls in the Bosphorus region has been conducted applying a 3-Dimensional model. The modelling is based on SYSTEM 3, which is a general modelling system for baroclinic flow simulating unsteady currents, waterlevels, salinity and temperature within the model area. The model set-up covers the Black Sea-Bosphorus-Marmara Sea junction area. The set-up is calibrated by data from a dedicated field program and previous field experience. The model is designed to describe the characteristic features of the flow in the junction area such as the effects of variations in waterlevel differences between the Sea of Marmara and the Black Sea on the important two-layer structure in the strait and the flow fields generated by the upper layer jet in the Bosphorus-Marmara junction. This model has been applied for evaluation of disposal of wastewater and for the subsequent water quality studies. The general use of a baroclinic 3-D hydrodynamic model to simulate disposal of wastewater is discussed. Examples of the application of the model of the junction area to evaluate the different strategies for disposal of wastewater are presented.


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