Toll-like receptor 4 signaling is associated with upregulated NADPH oxidase expression in peripheral T cells of children with autism

2017 ◽  
Vol 61 ◽  
pp. 146-154 ◽  
Author(s):  
Ahmed Nadeem ◽  
Sheikh F. Ahmad ◽  
Saleh A. Bakheet ◽  
Naif O. Al-Harbi ◽  
Laila Y. AL-Ayadhi ◽  
...  
Keyword(s):  
T Cells ◽  
Nadph Oxidase ◽  
Children With Autism ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Peripheral T Cells

Elevated expression of toll-like receptor 4 is associated with NADPH oxidase-induced oxidative stress in B cells of children with autism

2020 ◽  
Vol 84 ◽  
pp. 106555
Author(s):  
Naif O. Al-Harbi ◽  
Ahmed Nadeem ◽  
Sheikh F. Ahmad ◽  
Laila Y. AL-Ayadhi ◽  
Mohammad M. Al-Harbi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
B Cells ◽  
Nadph Oxidase ◽  
Children With Autism ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Elevated Expression

scholarly journals CD4+CD25+Foxp3+ regulatory T cells regulate immune balance in unexplained recurrent spontaneous abortion via the Toll-like receptor 4/nuclear factor-κB pathway

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052098094
Author(s):  
Shuang Qin ◽  
Li Li ◽  
Jia Liu ◽  
Jinrui Zhang ◽  
Qing Xiao ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Response ◽  
Mouse Model ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Unexplained Recurrent Spontaneous Abortion ◽  
Tlr4 Antagonist

Objective The present study aimed to evaluate the effects of cluster of differentiation (CD)4+CD25+ forkhead box p3 (Foxp3)+ regulatory T cells (Tregs) on unexplained recurrent spontaneous abortion (URSA) and the associated mechanisms. Methods The proportion of CD4+CD25+Foxp3+ Tregs and inflammatory cytokine concentrations in the peripheral blood of women with URSA were measured by flow cytometry and enzyme-linked immunosorbent assay, respectively. CBA/JxDBA/2J mating was used to establish an abortion-prone mouse model and the model mice were treated with the Toll-like receptor 4 (TLR4) antagonist E5564 and the TLR4 agonist lipopolysaccharide. Results The proportion of CD4+CD25+Foxp3+ Tregs was decreased and the inflammatory response was increased in women with URSA. In the abortion-prone mouse model, E5564 significantly increased the proportion of CD4+CD25+Foxp3+ Tregs, decreased the inflammatory response, and increased Foxp3 mRNA and protein expression. Lipopolysaccharide had adverse effects on the abortion-prone model. Conclusions These data suggest that CD4+CD25+Foxp3+ Tregs regulate immune homeostasis in URSA via the TLR4/nuclear factor-κB pathway, and that the TLR4 antagonist E5564 may be a novel and potential drug for treating URSA.

scholarly journals Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

2012 ◽  
Vol 109 (32) ◽  
pp. 13064-13069 ◽  
Author(s):  
J. M. Reynolds ◽  
G. J. Martinez ◽  
Y. Chung ◽  
C. Dong
Keyword(s):  
T Cells ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Autoimmune Inflammation

Th2 Inflammation reduces Toll-Like Receptor 4 Expression and Regulatory Functions of T Cells

2007 ◽  
Vol 119 (1) ◽  
pp. S308-S309 ◽  
Author(s):  
D. Préfontaine ◽  
M. Mazer ◽  
A. Banville-Langelier ◽  
P. Fiset ◽  
B.D. Mazer ◽  
...  
Keyword(s):  
T Cells ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Th2 Inflammation ◽  
Regulatory Functions

scholarly journals Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells

2013 ◽  
Vol 45 (2) ◽  
pp. e8-e8 ◽  
Author(s):  
Sung Nam Park ◽  
Kyung Tae Noh ◽  
Young-Il Jeong ◽  
In Duk Jung ◽  
Hyun Kyu Kang ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Tumor Growth ◽  
Cd8 T Cells ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Rhamnogalacturonan Ii
Sign in / Sign up

Export Citation Format

Share Document