Neuropeptide Y (NPY) prevents depressive-like behavior, spatial memory deficits and oxidative stress following amyloid-β (Aβ1–40) administration in mice

2013 ◽  
Vol 244 ◽  
pp. 107-115 ◽  
Author(s):  
Vanessa V. dos Santos ◽  
Danúbia B. Santos ◽  
Gilliard Lach ◽  
Ana Lúcia S. Rodrigues ◽  
Marcelo Farina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spatial Memory ◽  
Neuropeptide Y ◽  
Amyloid Β ◽  
Memory Deficits ◽  
And Oxidative Stress

Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease

2011 ◽  
Vol 71 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Lucian Hritcu ◽  
Alin Ciobica ◽  
Marius Stefan ◽  
Marius Mihasan ◽  
Lavinia Palamiuc ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spatial Memory ◽  
Memory Deficits ◽  
Rodent Model ◽  
Stress Damage ◽  
And Oxidative Stress

scholarly journals Protective effects of Huang-Lian-Jie-Du-Tang against Aβ25–35-induced memory deficits and oxidative stress in rats

2020 ◽  
Vol 48 (3) ◽  
pp. 030006051989385
Author(s):  
Wenbin Wu ◽  
Xiaojing He ◽  
Shuling Xie ◽  
Bin Li ◽  
Jinxin Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Memory Deficits ◽  
Protective Effects ◽  
And Oxidative Stress

Amentoflavone Ameliorates Aβ1–42-Induced Memory Deficits and Oxidative Stress in Cellular and Rat Model

2018 ◽  
Vol 43 (4) ◽  
pp. 857-868 ◽  
Author(s):  
Chao Chen ◽  
Bin Li ◽  
Guangqing Cheng ◽  
Xiaoni Yang ◽  
Ningning Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Memory Deficits ◽  
And Oxidative Stress

scholarly journals The Effects of Sesquiterpenes-Rich Extract ofAlpinia oxyphyllaMiq. on Amyloid-β-Induced Cognitive Impairment and Neuronal Abnormalities in the Cortex and Hippocampus of Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Shao-Huai Shi ◽  
Xu Zhao ◽  
Bing Liu ◽  
Huan Li ◽  
Ai-Jing Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amyloid Β ◽  
Clinical History ◽  
Memory Deficits ◽  
Term Treatment ◽  
Neuroprotective Activity ◽  
Nuclear Condensation ◽  
Alpinia Oxyphylla ◽  
Long Term Treatment

As a kind of medicine which can also be used as food,Alpinia oxyphyllaMiq. has a long clinical history in China. A variety of studies demonstrated the significant neuroprotective activity effects of chloroform (CF) extract from the fruits ofAlpinia oxyphylla.In order to further elucidate the possible mechanisms of CF extract which mainly contains sesquiterpenes with neuroprotection on the cognitive ability, mice were injected with Aβ1−42and later with CF in this study. The results showed that the long-term treatment of CF enhanced the cognitive performances in behavior tests, increased activities of glutathione peroxidase (GSH-px) and decreased the level of malondialdehyde (MDA), acetylcholinesterase (AChE), and amyloid-β(Aβ), and reversed the activation of microglia, degeneration of neuronal acidophilia, and nuclear condensation in the cortex and hippocampus. These results demonstrate that CF ameliorates learning and memory deficits by attenuating oxidative stress and regulating the activation of microglia and degeneration of neuronal acidophilia to reinforce cholinergic functions.

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