Semliki Forest virus vectors expressing transforming growth factor beta inhibit experimental autoimmune encephalomyelitis in Balb/c mice

2007 ◽  
Vol 355 (3) ◽  
pp. 776-781 ◽  
Author(s):  
Markus J.V. Vähä-Koskela ◽  
Tiina I. Kuusinen ◽  
Jeanette C. Holmlund-Hampf ◽  
Petra T. Furu ◽  
Jari E. Heikkilä ◽  
...  
Keyword(s):  
Growth Factor ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Semliki Forest Virus ◽  
Autoimmune Encephalomyelitis ◽  
Virus Vectors ◽  
Growth Factor Beta ◽  
Experimental Autoimmune

scholarly journals Erythropoietin Ameliorates Rat Experimental Autoimmune Neuritis by Inducing Transforming Growth Factor-Beta in Macrophages

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e26280 ◽  
Author(s):  
Anne K. Mausberg ◽  
Gerd Meyer zu Hörste ◽  
Thomas Dehmel ◽  
Mark Stettner ◽  
Helmar C. Lehmann ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Experimental Autoimmune Neuritis ◽  
Growth Factor Beta ◽  
Experimental Autoimmune

The Regulatory Effect of Liuwei Dihuang Pills on Cytokines in Mice with Experimental Autoimmune Encephalomyelitis

2012 ◽  
Vol 40 (02) ◽  
pp. 295-308 ◽  
Author(s):  
Yan Liu ◽  
Hui Zhao ◽  
Jie Zhang ◽  
Ping Zhang ◽  
Ming Li ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Mrna Expression ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Demyelinating Diseases ◽  
Regulatory Effect ◽  
Autoimmune Encephalomyelitis ◽  
Tnf Α ◽  
Liuwei Dihuang Pills ◽  
Experimental Autoimmune

The regulatory effect of Liuwei Dihuang Pills (LDP) was studied on cytokines in mice with experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis (MS), induced by immunization with MOG35-55 and complete Freund's adjuvant (CFA) supplemented with pertussis toxin (PTX). LDP was administrated orally for 40 days, and prednisone acetate (PA) was used as a control. The pathological changes in the spinal cords of mice were observed by light microscope with hematoxylin-eosin (HE) staining and transmission electron microscope (TEM). The protein and mRNA expression of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in the spinal cords were assessed by immunohistochemistry and RT-PCR assay, and the cyclic adenosine monophosphate (cAMP) in mice plasma was measured by radioimmunoassay (RIA) on days 12, 25 and 40 post-immunization (PI). The results showed that inflammatory cells, demyelination and axonal loss were reduced, and that the protein and mRNA expression of TNF-α and the ratio of TNF-α/TGF-β were obviously decreased, to different extents. However, the levels of cAMP were enhanced in LDP-treated groups. These findings suggested that LDP regulates the cytokine balance in favor of T helper 1 (Th1)/regulatory T (Treg) cells, which depend on enhancement of cAMP levels. LDP has a potential role in the treatment of MS and other demyelinating diseases of the central nervous system.

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