Induction of chondrogenesis and expression of superficial zone protein (SZP)/lubricin by mesenchymal progenitors in the infrapatellar fat pad of the knee joint treated with TGF-β1 and BMP-7

2008 ◽  
Vol 376 (1) ◽  
pp. 148-153 ◽  
Author(s):  
Sang Yang Lee ◽  
Toshiyuki Nakagawa ◽  
A. Hari Reddi
Keyword(s):  
Knee Joint ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Superficial Zone ◽  
Mesenchymal Progenitors ◽  
Superficial Zone Protein ◽  
Tgf Β1

scholarly journals Phosphorus Concentration in Knee Joint Structures of Patients Following Replacement Surgery

2019 ◽  
Vol 16 (4) ◽  
pp. 525 ◽  
Author(s):  
Ciosek Żaneta ◽  
Kosik-Bogacka Danuta ◽  
Łanocha-Arendarczyk Natalia ◽  
Kot Karolina ◽  
Karaczun Maciej ◽  
...  
Keyword(s):  
Knee Joint ◽  
Cruciate Ligament ◽  
The Body ◽  
Infrapatellar Fat Pad ◽  
Emission Spectrometry ◽  
Phosphorus Concentration ◽  
Spongy Bone ◽  
Fat Pad ◽  
Hoffa’S Fat Pad ◽  
P Concentration

The aim of the study was to assess phosphorus (P) concentration in structures of the knee joint—including the tibial spongy bone, articular cartilage, meniscus, anterior cruciate ligament, and infrapatellar fat pad (Hoffa’s fat pad)—of patients following knee joint replacement. The study also aimed to assess the influence of selected biological and environmental factors on P concentration in studied parts of the knee joint. Phosphorus concentration was determined using inductively coupled plasma-atomic emission spectrometry (ICP-AES). Statistically significant differences in P concentration were found between different elements of the knee joint. The highest P concentration was measured in the spongy bone (72,746.68 mg kg−1 dw) and the lowest in the Hoffa’s fat pad (1203.19 mg kg−1 dw). P levels were unaffected by gender, age, BMI, place of residence, smoking, or alcohol consumption. Data on P concentration in the osteoarticular elements of the knee may be useful in the interpretation and evaluation of biochemical, morphological, and mechanical changes occurring in the body.

scholarly journals Factors Affecting the Aluminum, Arsenic, Cadmium and Lead Concentrations in the Knee Joint Structures

2021 ◽  
Vol 9 ◽  
Author(s):  
Guoyong Li ◽  
Chunfeng Xiong ◽  
Wenhua Xu ◽  
Runhong Mei ◽  
Tao Cheng ◽  
...  
Keyword(s):  
Knee Joint ◽  
Cancellous Bone ◽  
Toxic Elements ◽  
Cruciate Ligament ◽  
Toxic Element ◽  
Infrapatellar Fat Pad ◽  
Diabetic Patients ◽  
Fat Pad ◽  
Femoral Cartilage ◽  
Anterior Cruciate

Background: Toxic elements, such as aluminum (Al), arsenic (As), cadmium (Cd), and lead (Pb), are persistent environmental pollutants that can cause adverse effects on the health of exposed individuals. Bone is one of the primary target organs of accumulation and potential damage from toxic elements.Objectives: This study was performed to determine the Al, As, Cd, and Pb concentrations in the femoral cancellous bone, femoral cartilage, anterior cruciate ligament, meniscus, tibial cartilage, tibial cancellous bone and infrapatellar fat pad. Furthermore, the aim of this study was to explore the relationships between toxic element concentrations and related factors such as gender, age, place of residence, hypertension and diabetes, and to determine the correlations among these toxic elements in knee joint structures.Methods: The samples used this study were collected from 51 patients following total knee arthroplasty. The Al, As, Cd, and Pb concentrations were determined using inductively coupled plasma optic emission spectrometry.Results: Significant differences were found in the Al, As, Cd, and Pb concentrations among the knee joint structures. Cd concentration in the tibial cancellous bone in women was significantly higher than in men. Pb concentration in the infrapatellar fat pad of urban patients was significantly higher as compared to rural patients. Al concentrations in the femoral cancellous bone, femoral cartilage, anterior cruciate ligament, meniscus and tibial cartilage were significantly higher in patients living in urban areas than in rural areas. As concentration in the tibial cancellous bone of diabetic patients was significantly higher compared to non-diabetic patients. In addition, significant Spearman's positive correlations were found between Al and Pb in the knee joint structures.Conclusion: The obtained results of the investigated toxic elements may serve as a basis for establishing the reference values of Al, As, Cd, and Pb in the knee joint structures. The results reported in the study provides novel data regarding the relationships between the toxic element concentrations and gender, age, place of residence, hypertension and diabetes in the studied structures of knee joint. Furthermore, new interactions among these toxic elements were noted.

scholarly journals Degenerative joint disease induced by repeated intra-articular injections of monosodium urate crystals in rats as investigated by translational imaging

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Nathalie Accart ◽  
Janet Dawson ◽  
Michael Obrecht ◽  
Christian Lambert ◽  
Manuela Flueckiger ◽  
...  
Keyword(s):  
Knee Joint ◽  
Inflammatory Cells ◽  
Cyst Formation ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Infrapatellar Fat Pad ◽  
Monosodium Urate ◽  
Fat Pad ◽  
Crystal Deposition ◽  
Translational Imaging

AbstractThe objective of this work was to assess the consequences of repeated intra-articular injection of monosodium urate (MSU) crystals with inflammasome priming by lipopolysaccharide (LPS) in order to simulate recurrent bouts of gout in rats. Translational imaging was applied to simultaneously detect and quantify injury in different areas of the knee joint. MSU/LPS induced joint swelling, synovial membrane thickening, fibrosis of the infrapatellar fat pad, tidemark breaching, and cartilage invasion by inflammatory cells. A higher sensitivity to mechanical stimulus was detected in paws of limbs receiving MSU/LPS compared to saline-injected limbs. In MSU/LPS-challenged joints, magnetic resonance imaging (MRI) revealed increased synovial fluid volume in the posterior region of the joint, alterations in the infrapatellar fat pad reflecting a progressive decrease of fat volume and fibrosis formation, and a significant increase in the relaxation time T2 in femoral cartilage, consistent with a reduction of proteoglycan content. MRI also showed cyst formation in the tibia, femur remodeling, and T2 reductions in extensor muscles consistent with fibrosis development. Repeated intra-articular MSU/LPS injections in the rat knee joint induced pathology in multiple tissues and may be a useful means to investigate the relationship between urate crystal deposition and the development of degenerative joint disease.

Intraarticular fibroma of the tendon sheath arising from the infrapatellar fat pad in the knee joint

2007 ◽  
Vol 129 (3) ◽  
pp. 291-294 ◽  
Author(s):  
Osman Aynaci ◽  
Servet Kerimoglu ◽  
Cagatay Ozturk ◽  
Metehan Saracoglu ◽  
Kadriye Yildiz
Keyword(s):  
Knee Joint ◽  
Tendon Sheath ◽  
Infrapatellar Fat Pad ◽  
Fat Pad

Pathophysiology of obesity on knee joint homeostasis: contributions of the infrapatellar fat pad

2016 ◽  
Vol 26 (2) ◽  
Author(s):  
Kelly S. Santangelo ◽  
Lauren B. Radakovich ◽  
Josie Fouts ◽  
Michelle T. Foster
Keyword(s):  
Knee Joint ◽  
Weight Bearing ◽  
Epidemiological Studies ◽  
Metabolic Effects ◽  
Infrapatellar Fat Pad ◽  
Inflammatory Factors ◽  
Bone Homeostasis ◽  
Fat Pad ◽  
Local Factors ◽  
Adipose Depot

AbstractOsteoarthritis (OA) is a debilitating condition characterized by inflammation, breakdown, and consequent loss of cartilage of the joints. Epidemiological studies indicate obesity is an important risk factor involved in OA initiation and progression. Traditional views propose OA to be a biomechanical consequence of excess weight on weight-bearing joints; however, emerging data demonstrates that systemic and local factors released from white adipose depots play a role. Hence, current views characterize OA as a condition exacerbated by a metabolic link related to adipose tissue, and not solely related to redistributed/altered weight load. Factors demonstrated to influence cartilage and bone homeostasis include adipocyte-derived hormones (“adipokines”) and adipose depot released cytokines. Epidemiological studies demonstrate a positive relation between systemic circulating cytokines, leptin, and resistin with OA types, while the association with adiponectin is controversial. Local factors in joints have also been shown to play a role in OA. In particular, this includes the knee, a weight-bearing joint that encloses a relatively large adipose depot, the infrapatellar fat pad (IFP), which serves as a source of local inflammatory factors. This review summarizes the relation of obesity and OA as it specifically relates to the IFP and other integral supporting structures. Overall, studies support the concept that metabolic effects associated with systemic obesity also extend to the IFP, which promotes inflammation, pain, and cartilage destruction within the local knee joint environment, thus contributing to development and progression of OA.

scholarly journals High-fat feeding primes the mouse knee joint to develop osteoarthritis and pathologic infrapatellar fat pad changes after surgically induced injury

2020 ◽  
Vol 28 (5) ◽  
pp. 593-602 ◽  
Author(s):  
K. Warmink ◽  
A.E. Kozijn ◽  
I. Bobeldijk ◽  
R. Stoop ◽  
H. Weinans ◽  
...  
Keyword(s):  
Knee Joint ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
High Fat ◽  
Surgically Induced ◽  
Fat Feeding

scholarly journals Impact of Varied Factors on Iron, Nickel, Molybdenum and Vanadium Concentrations in the Knee Joint

2020 ◽  
Vol 17 (3) ◽  
pp. 813 ◽  
Author(s):  
Karolina Kot ◽  
Danuta Kosik-Bogacka ◽  
Paweł Ziętek ◽  
Maciej Karaczun ◽  
Żaneta Ciosek ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Knee Joint ◽  
Cruciate Ligament ◽  
Argon Plasma ◽  
Infrapatellar Fat Pad ◽  
Spongy Bone ◽  
Fat Pad ◽  
Diet Supplements ◽  
Significant Difference ◽  
Iron Nickel

The aim of this study was to determine the concentrations of iron, nickel, molybdenum, and vanadium in the knee joint. We also examined the relationships between the concentrations of these metals in the knee joint and the influence of varied factors on the concentration of Fe, Ni, Mo, and V. The study of these trace elements is important, because these elements are used alone and in combination in diet supplements, and they are components of biomaterials implanted in medicine. The study materials, consisting of the spongy bone, cartilage, meniscus, anterior cruciate ligament (ACL), and infrapatellar fat pad, were obtained from 34 women and 12 men from northwestern Poland. The concentrations of Ni, Fe, Mo, and V were determined using spectrophotometric atomic absorption in inductively coupled argon plasma (ICP-AES). We found significantly higher Mo concentrations in the ACL of women than men. There was a significant difference in the Mo concentration in the spongy bone between patients from cities with fewer than 100,000 inhabitants and patients from cities with more than 100,000 residents. Iron concentrations in the spongy bone were higher in non-smoking patients and those who did not consume alcohol. Vanadium concentrations were higher in the infrapatellar fat pads in abstainers. In patients who had not undergone arthroscopy surgery, V concentration was lower in cartilage. The concentrations of V in the cartilage and infrapatellar fat pad were higher in osteoporotic patients than in non-osteoporotic patients. There were significant differences in Fe concentrations in the meniscus, with the lowest in osteoporotic patients. We noted lower Mo concentrations in the spongy bone of patients with rheumatoid arthritis. Furthermore, we noted some new interactions among metals in the studied structures of the knee joint. The results reported in this study show the influence of gender, place of residence, smoking, consumption of alcohol, arthroscopy surgery, osteoporosis, and rheumatoid arthritis on the Fe, Ni, Mo, and V concentrations in the studied structures of the knee joint.

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