Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein

2017 ◽  
Vol 493 (4) ◽  
pp. 1384-1389
Author(s):  
Norimichi Itoh ◽  
Taku Nagai ◽  
Takashi Watanabe ◽  
Kentaro Taki ◽  
Toshitaka Nabeshima ◽  
...  
Keyword(s):  
Gtpase Activating Protein ◽  
Interacting Protein ◽  
Iq Motif

Proteomics analysis of liver pathological calcification suggests a role for the IQ motif containing GTPase activating protein 1 in myofibroblast function

2009 ◽  
Vol 3 (3) ◽  
pp. 307-321 ◽  
Author(s):  
Fariba Kalantari ◽  
Patrick Auguste ◽  
Tahereh Ziafazeli ◽  
George Tzimas ◽  
Lars Malmström ◽  
...  
Keyword(s):  
Gtpase Activating Protein ◽  
Proteomics Analysis ◽  
Iq Motif ◽  
Pathological Calcification

scholarly journals IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129314 ◽  
Author(s):  
Amr M. Ghaleb ◽  
Agnieszka B. Bialkowska ◽  
Ashley J. Snider ◽  
Dmitri V. Gnatenko ◽  
Yusuf A. Hannun ◽  
...  
Keyword(s):  
Gtpase Activating Protein ◽  
Colonic Inflammation ◽  
Iq Motif

scholarly journals Grit, a GTPase-Activating Protein for the Rho Family, Regulates Neurite Extension through Association with the TrkA Receptor and N-Shc and CrkL/Crk Adapter Molecules

2002 ◽  
Vol 22 (24) ◽  
pp. 8721-8734 ◽  
Author(s):  
Takeshi Nakamura ◽  
Misako Komiya ◽  
Kiyoaki Sone ◽  
Eiji Hirose ◽  
Noriko Gotoh ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Rho Gtpases ◽  
Rho Gtpase ◽  
Neuronal Cells ◽  
Small Gtpases ◽  
Actin Dynamics ◽  
Gtpase Activating Protein ◽  
Interacting Protein ◽  
High Affinity Receptor ◽  
Rho Family

ABSTRACT Neurotrophins are key regulators of the fate and shape of neuronal cells and act as guidance cues for growth cones by remodeling the actin cytoskeleton. Actin dynamics is controlled by Rho GTPases. We identified a novel Rho GTPase-activating protein (Grit) for Rho/Rac/Cdc42 small GTPases. Grit was abundant in neuronal cells and directly interacted with TrkA, a high-affinity receptor for nerve growth factor (NGF). Another pool of Grit was recruited to the activated receptor tyrosine kinase through its binding to N-Shc and CrkL/Crk, adapter molecules downstream of activated receptor tyrosine kinases. Overexpression of the TrkA-binding region of Grit inhibited NGF-induced neurite elongation. Further, we found some tendency for neurite promotion in full-length Grit-overexpressing PC12 cells upon NGF stimulation. These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases.

scholarly journals Identification of Rab GTPase-Activating Protein-Like Protein (RabGAPLP) as a Novel Alix/AIP1-Interacting Protein

2005 ◽  
Vol 69 (4) ◽  
pp. 861-865 ◽  
Author(s):  
Fumitaka ICHIOKA ◽  
Mio HORII ◽  
Keiichi KATOH ◽  
Yoshinori TERASAWA ◽  
Hideki SHIBATA ◽  
...  
Keyword(s):  
Rab Gtpase ◽  
Gtpase Activating Protein ◽  
Interacting Protein

scholarly journals Colocalization of IQGAP1 with DLC-1 and PLC-δ1; Its potential role in coronary spasm

2019 ◽  
Author(s):  
Makoto Tanaka ◽  
Tomohiro Osanai ◽  
Yoshimi Homma ◽  
Kenji Hanada ◽  
Ken Okumura ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Calcium Concentration ◽  
Potential Role ◽  
Coronary Spasm ◽  
Lipid Transfer ◽  
Gtpase Activating Protein ◽  
Linear Arrays ◽  
Iq Motif ◽  
Start Domain ◽  
Steroidogenic Acute Regulatory

AbstractPhospholipase C (PLC)-δ1, activated by p122RhoGTPase-activating protein (GAP)/deleted in liver cancer-1 (p122RhoGAP/DLC-1), contributes to the coronary spastic angina (CSA) pathogenesis. The present study aims to further investigate the p122RhoGAP/DLC-1 protein. We examined molecules assisting this protein and identified a scaffold protein—IQ motif-containing GTPase-activating protein 1 (IQGAP1). IQGAP1-C binds to the steroidogenic acute regulatory-related lipid transfer (START) domain of p122RhoGAP/DLC-1, and PLC-δ1 binds to IQGAP1-N, forming a complex. In fluorescence microscopy, small dots of PLC-δ1 created fine linear arrays like microtubules, and IQGAP1 and p122RhoGAP/DLC-1 were colocated in the cytoplasm with PLC-δ1. Ionomycin induced the raft recruitment of the PLC-δ1, IQGAP1, and p122RhoGAP/DLC-1 complex by translocation to the plasma membrane (PM), indicating the movement of this complex is along microtubules with the motor protein kinesin. Moreover, the IQGAP1 protein was elevated in skin fibroblasts obtained from patients with CSA, and it enhanced the PLC activity and peak intracellular calcium concentration in response to acetylcholine. IQGAP1, a novel stimulating protein, forms a complex with p122RhoGAP/DLC-1 and PLC-δ1 that moves along microtubules and enhances the PLC activity.

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