Regulating the surface poly(ethylene glycol) density of polymeric nanoparticles and evaluating its role in drug delivery in vivo

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

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In vitro and in vivo investigation of chitosan–polylysine polymeric nanoparticles for ovalbumin and CpG co-delivery

RSC Advances ◽

10.1039/c7ra06450k ◽

2017 ◽

Vol 7 (63) ◽

pp. 39962-39969 ◽

Cited By ~ 5

Author(s):

Yunfei Han ◽

Qian Duan ◽

Yanhui Li ◽

Jian Tian

Keyword(s):

Ethylene Glycol ◽

Delivery System ◽

Polymeric Nanoparticles ◽

Poly Ethylene Glycol ◽

Glycol Chitosan ◽

Vaccine Delivery System ◽

Electrostatic Binding ◽

Poly Ethylene

A simple and powerful vaccine delivery system was developed by electrostatic binding of chitosan-based polycation methoxy poly(ethylene glycol)–chitosan–poly(l-lysine) (mPEG–CS–PLL) with ovalbumin (OVA) and cytosine–phosphate–guanine (CpG).

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Synthesis and in vitro and in vivo evaluations of poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) magnetic nanoparticles containing doxorubicin as a potential targeted drug delivery system

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2014.03.025 ◽

2014 ◽

Vol 118 ◽

pp. 140-147 ◽

Cited By ~ 29

Author(s):

Magdalena Hałupka-Bryl ◽

Kei Asai ◽

Sindhu Thangavel ◽

Magdalena Bednarowicz ◽

Ryszard Krzyminiewski ◽

...

Keyword(s):

Drug Delivery ◽

Magnetic Nanoparticles ◽

Ethylene Glycol ◽

Targeted Drug Delivery ◽

Poly Ethylene Glycol ◽

Targeted Drug ◽

Poly Ethylene ◽

Targeted Drug Delivery System

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Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)–Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo

Molecular Pharmaceutics ◽

10.1021/mp500399j ◽

2014 ◽

Vol 11 (10) ◽

pp. 3656-3670 ◽

Cited By ~ 56

Author(s):

Xingxing Chuan ◽

Qin Song ◽

Jialiang Lin ◽

Xianhui Chen ◽

Hua Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Antitumor Activity ◽

Ethylene Glycol ◽

Poly Ethylene Glycol ◽

Drug Conjugate ◽

Intracellular Drug Delivery ◽

Redox Responsive ◽

Poly Ethylene

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Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽

10.3390/molecules26051438 ◽

2021 ◽

Vol 26 (5) ◽

pp. 1438

Author(s):

Silvio Curia ◽

Feifei Ng ◽

Marie-Emérentienne Cagnon ◽

Victor Nicoulin ◽

Adolfo Lopez-Noriega

Keyword(s):

Ethylene Glycol ◽

Ring Opening ◽

Gel Chromatography ◽

Amphiphilic Copolymers ◽

Trimethylene Carbonate ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

Long Acting ◽

In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

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Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽

10.1039/c6ra03718f ◽

2016 ◽

Vol 6 (29) ◽

pp. 24142-24153

Author(s):

Andreea S. Voda ◽

Kevin Magniez ◽

Nisa V. Salim ◽

Cynthia Wong ◽

Qipeng Guo

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Self Assembly ◽

Triblock Copolymers ◽

Potential Drug ◽

Poly Ethylene Glycol ◽

Drug Delivery Applications ◽

Poly Ethylene ◽

First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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