Improved breast cancer cell-specific intracellular drug delivery and therapeutic efficacy by coupling decoration with cell penetrating peptide and SP90 peptide

2016 ◽  
Vol 84 ◽  
pp. 1783-1791 ◽  
Author(s):  
Li-Qiang Fan ◽  
Guo-Xiu Du ◽  
Peng-Fei Li ◽  
Ming-Wei Li ◽  
Yao Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Therapeutic Efficacy ◽  
Cell Penetrating Peptide ◽  
Intracellular Drug Delivery ◽  
Cell Penetrating

scholarly journals Formulation of Piperine–Chitosan-Coated Liposomes: Characterization and In Vitro Cytotoxic Evaluation

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3281
Author(s):  
Syed Sarim Imam ◽  
Sultan Alshehri ◽  
Mohammad A. Altamimi ◽  
Afzal Hussain ◽  
Wajhul Qamar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Therapeutic Efficacy ◽  
Cancer Cell Line ◽  
Permeation Study ◽  
Study Results

The present research work is designed to prepare and evaluate piperine liposomes and piperine–chitosan-coated liposomes for oral delivery. Piperine (PPN) is a water-insoluble bioactive compound used for different diseases. The prepared formulations were evaluated for physicochemical study, mucoadhesive study, permeation study and in vitro cytotoxic study using the MCF7 breast cancer cell line. Piperine-loaded liposomes (PLF) were prepared by the thin-film evaporation method. The selected liposomes were coated with chitosan (PLFC) by electrostatic deposition to enhance the mucoadhesive property and in vitro therapeutic efficacy. Based on the findings of the study, the prepared PPN liposomes (PLF3) and chitosan coated PPN liposomes (PLF3C1) showed a nanometric size range of 165.7 ± 7.4 to 243.4 ± 7.5, a narrow polydispersity index (>0.3) and zeta potential (−7.1 to 29.8 mV). The average encapsulation efficiency was found to be between 60 and 80% for all prepared formulations. The drug release and permeation study profile showed biphasic release behavior and enhanced PPN permeation. The in vitro antioxidant study results showed a comparable antioxidant activity with pure PPN. The anticancer study depicted that the cell viability assay of tested PLF3C2 has significantly (p < 0.001)) reduced the IC50 when compared with pure PPN. The study revealed that oral chitosan-coated liposomes are a promising delivery system for the PPN and can increase the therapeutic efficacy against the breast cancer cell line.

In vitro Evaluation of Carbon‐Based Nanospheres as Drug Delivery Vesicles in Breast Cancer Cell

2019 ◽  
Vol 41 (2) ◽  
pp. 112-116
Author(s):  
Daehyun Kim ◽  
Hyuna Kyung ◽  
Seung Soo Lee ◽  
So Yeon Park ◽  
Won Cheol Yoo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
In Vitro Evaluation ◽  
Carbon Based

gH625 Cell-Penetrating Peptide Promotes the Endosomal Escape of Nanovectorized siRNA in a Triple-Negative Breast Cancer Cell Line

2019 ◽  
Vol 20 (8) ◽  
pp. 3076-3086 ◽  
Author(s):  
Sanaa Ben Djemaa ◽  
Katel Hervé-Aubert ◽  
Laurie Lajoie ◽  
Annarita Falanga ◽  
Stefania Galdiero ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cell Line ◽  
Triple Negative ◽  
Cancer Cell Line ◽  
Endosomal Escape ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals Novel pH-sensitive and biodegradable micelles for the combined delivery of doxorubicin and conferone to induce apoptosis in MDA-MB-231 breast cancer cell line

RSC Advances ◽  
2020 ◽  
Vol 10 (49) ◽  
pp. 29228-29246 ◽  
Author(s):  
Akram Rahmani ◽  
Hassan Zavvar Mousavi ◽  
Roya Salehi ◽  
Ahmad Bagheri
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Chemotherapy ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Ph Sensitive ◽  
Line P

pH-sensitive micelles are desirable for co-drug delivery in cancer chemotherapy.

Co-biomembrane coated Fe3O4/MnO2 multifunctional nanoparticles for targeted delivery and enhanced hemodynamic/photothermal/chemo therapy

2021 ◽  
Author(s):  
Yingshu Guo ◽  
Xiaofei Zheng ◽  
Tingting Gai ◽  
Zhiyong Wei ◽  
Shu-Sheng Zhang
Keyword(s):  
Breast Cancer ◽  
Escherichia Coli ◽  
Drug Delivery ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Targeted Delivery ◽  
Membrane System ◽  
Multifunctional Nanoparticles ◽  
Mcf 7

Here, the co-membrane system of MCF-7 breast cancer cell membrane (MM) and Escherichia coli membrane (EM)-coated Fe3O4/MnO2 multifunctional composite nanoparticles loaded with DOX (Fe3O4/MnO2/MM/EM/D) was used for targeting drug delivery...

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