Renal-protective effects of n -hexane layer from morning glory seeds ethanol extract

2017 ◽  
Vol 95 ◽  
pp. 1661-1668 ◽  
Author(s):  
Yanli Shao ◽  
Bongkyun Park ◽  
Yoon-Jae Song ◽  
Dae Won Park ◽  
Eun-Hwa Sohn ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Morning Glory ◽  
Protective Effects ◽  
Hexane Layer

Protective effects of ethanol extract of a Mexican propolis on indomethacin-induced gastric mucosal damage in mice.

2019 ◽  
Author(s):  
DV Pilar ◽  
VVS Ibran ◽  
RC Mario ◽  
CA Octavio ◽  
MM Canales-Martinez ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Protective Effects

Anti-Apoptotic and Anti-Inflammatory Activities of Edible Fresh Water Algae Prasiola japonica in UVB-Irradiated Skin Keratinocytes

2019 ◽  
Vol 47 (08) ◽  
pp. 1853-1868
Author(s):  
Eunju Choi ◽  
Young-Su Yi ◽  
Jongsung Lee ◽  
Sang Hee Park ◽  
Sunggyu Kim ◽  
...  
Keyword(s):  
Fresh Water ◽  
Ethanol Extract ◽  
The Body ◽  
Hacat Cells ◽  
Protective Effects ◽  
Proteolytic Activation ◽  
Skin Keratinocytes ◽  
External Stresses ◽  
Anti Oxidant ◽  
Anti Inflammatory

Skin is the outer tissue layer and is a barrier protecting the body from various external stresses. The fresh water green edible algae Prasiola japonica has antiviral, antimicrobial, and anti-inflammatory properties; however, few studies of its effects on skin-protection have been reported. In this study, Prasiola japonica ethanol extract (Pj-EE) was prepared, and its skin-protective properties were investigated in skin keratinocytes. Pj-EE inhibited ROS production in UVB-irradiated HaCaT cells without cytotoxicity. Pj-EE also suppressed the apoptotic death of UVB-irradiated HaCaT cells by decreasing the generation of apoptotic bodies and the proteolytic activation of apoptosis caspase-3, -8, and -9. Moreover, Pj-EE downregulated the mRNA expression of the inflammatory gene cyclooxygenase-2 (COX-2), the pro-inflammatory cytokine genes interleukin (IL)-1[Formula: see text], IL-8, IL-6, tumor necrosis factor (TNF)-[Formula: see text], and interferon (IFN)-[Formula: see text], and the tissue remodeling genes matrix metalloproteinase (MMP)-1, -2, -3, and -9. The Pj-EE-induced anti-inflammatory effect was mediated by suppressing the activation of nuclear factor-kappa B (NF-[Formula: see text]B) signaling pathway in the UVB-irradiated HaCaT cells. Taken together, these results suggest that Pj-EE exerts skin-protective effects through anti-oxidant, anti-apoptotic, and anti-inflammatory activities in skin keratinocytes.

Erratum to “Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats”

Phytomedicine ◽  
2009 ◽  
Vol 16 (11) ◽  
pp. 1076
Author(s):  
M. Galisteo ◽  
A. Suárez ◽  
M.P. Montilla ◽  
M.I. Torres ◽  
A. Gil ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Ethanol Extract ◽  
Protective Effects

scholarly journals Protective effects of ethanolic extract of Alhagi maurorum roots on renal failure induced by acetaminophen in mice

2021 ◽  
Vol 8 (1) ◽  
pp. 16-22
Author(s):  
Seham I AL-Nafea ◽  
Mohammed O Aljahdali
Keyword(s):  
Oxidative Stress ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Serum Levels ◽  
High Dose ◽  
Root Extract ◽  
Protective Effects ◽  
Oxidative Stress Biomarkers ◽  
Protective Actions ◽  
And Oxidative Stress

The protective actions of ethanol Alhagi maurorum (AM) root ethanol extract on acetaminophen-induced oxidative stress and renal toxicity in mice was evaluated. Forty male SWR strain albino mice aged 8 weeks were grouped into five groups. G1 (n=5): as control. G2 (n=5): administered orally a single dose of acetaminophen (2000mg/kg). G3 (n=10) administrated orally 200 mg/kg of roots ethanol extract for one week then acetaminophen as G2 at 8th day and; G4 (n=10) administrated orally 400 mg/kg of roots ethanol extract for one week then acetaminophen as G2 at 8th day; G5 (n=10) administrated orally 600 mg/kg of roots ethanol extract for one week then acetaminophen as G2 at 8th day. At end of experiments, the mice were killed under anesthesia and blood samples were gathered to preform complete blood test (CBC), serum levels of urea and creatinine and oxidative stress biomarkers as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) using available Elisa mice kits. Kidneys were removed and histologically examined. Acetaminophen intake significantly elevated WBCs, neutrophils, monocytes, urea and creatinine levels and significantly decreased RBCs, hemoglobin, hematocrit, GSH, SOD and CAT (P <0.05). Treatment with Alhagi maurorum roots extract especially high dose (600 mg/kg) resulted in decreased in WBCs, neutrophils, monocytes, urea and creatinine levels and significantly increased RBCs, hemoglobin, hematocrit, GSH, SOD and CATversusacetaminophen group. Alhagi maurorum root extract treatment similarly decreased renal histological alteration induced by acetaminophen. This study can be utilized as prove of reading that Alhagi maurorum ethanol root extract especially high dose might be administered to prevent renal destruction induced by acetaminophen due to its antioxidant activity

scholarly journals Protective Effects of Xylopia aethiopica Fruit Ethanol Extract on Cadmium-Induced Inflammation and Dyslipidemia in Male Albino Rats

2021 ◽  
Author(s):  
Peter Folorunsho Ayodele ◽  
Dorcas Ibukun Akinloye ◽  
Adio Jaimiu Akamo ◽  
David Adejare Agboola ◽  
Oluseyi Adeboye Akinloye
Keyword(s):  
Tumor Necrosis ◽  
Ethanol Extract ◽  
Interleukin 10 ◽  
Protective Role ◽  
Albino Rats ◽  
Protective Effects ◽  
Inflammatory Changes ◽  
Cd Exposure ◽  
Xylopia Aethiopica ◽  
Necrosis Factor

The wide use of cadmium (Cd) in industry causes great environmental health problems to humans and animals. The aim of this study was to investigate the protective effects of Xylopia aethiopica fruit ethanol extract (XAFEE) on cadmium-induced inflammation and dyslipidemia in male albino rats. Thirty albino rats weighing 120&ndash;180 g were randomly selected into six groups (n = 5): control rats (administered distilled water only), Cd alone group (10 mg/ kg bw), Cd + 150 mg/kgbw XAFEE, Cd + 300 mg/kgbw XAFEE, 150 mg/kgbw XAFEE and 300 mg /kgbw XAFEE groups after 2-week acclimatization. The experiment lasted for 21 days, after which blood sample was collected by cardiac puncture. Changes in tumor necrosis factor (TNF-&alpha;), interleukin 10 (IL-10), total cholesterol (TC), triacylglycerol (TAG), phospholipids and free fatty acids (FFAs) concentrations in serum were determined. The results of the present study indicated that Cd exposure remarkably increased (p &lt; 0.05) the TC, TAG, phospholipids, FFAs and TNF-&alpha; concentrations, and significantly decreased IL-10 concentration (p &lt; 0.05). These findings suggest that inflammatory changes and alterations in lipid metabolism might be one of the mechanisms underlying the subtle effects of Cd toxicity, &ldquo;dyslipidemia.&rdquo; XAFEE expressed protective role against toxic influence of Cd on affected parameters in rats. The results raised the possibility of Xylopia aethiopica fruit being considered as a condiment in soup, local drinks, supplements or herbs preparations in areas where there are chances of Cd exposure, occupationally or environmentally.

scholarly journals Protective Effects of a Lycium chinense Ethanol Extract through Anti-oxidative Stress on Acute gastric lesion mice

2015 ◽  
Vol 30 (6) ◽  
pp. 63-68 ◽  
Author(s):  
AhReum Lee ◽  
JooYoung Lee ◽  
MinYeong Kim ◽  
Mi-Rae Shin ◽  
SungHo Shin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Lesion ◽  
Ethanol Extract ◽  
Protective Effects ◽  
Lycium Chinense

scholarly journals Protective Effect of Cicer arietinum L. (Chickpea) Ethanol Extract in the Dextran Sulfate Sodium-Induced Mouse Model of Ulcerative Colitis

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 456 ◽  
Author(s):  
Mia Kim ◽  
Kyung-Sook Chung ◽  
Se-Jung Hwang ◽  
Ye Seul Yoon ◽  
Young Pyo Jang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Mrna Expression ◽  
Cicer Arietinum ◽  
Inflammatory Mediators ◽  
Clinical Symptoms ◽  
Activity Index ◽  
Disease Activity Index ◽  
Ethanol Extract ◽  
Spleen Weight ◽  
Protective Effects

Inflammatory bowel disease (IBD) is a major risk factor of colorectal cancer. Drugs currently used for IBD exhibit adverse effects including vomiting, nausea, and diarrhea. Naturally derived novel alternative therapies are required to overcome these limitations. In this study, we investigated the protective effects of ethanol extract of Cicer arietinum (CEE) in a dextran sodium sulfate (DSS)-induced mouse model of colitis. CEE markedly improved DSS-induced clinical symptoms and histological status, such as the disease activity index, spleen weight, and colon length. Moreover, CEE-treated mice showed significant recovery of DSS-induced crypt damage and cell death. CEE suppressed myeloperoxidase (MPO) activity and macrophage marker F4/80 mRNA expression in colonic tissue of mice with DSS-induced colitis, indicating neutrophil infiltration and macrophage accumulation, respectively. Although DSS upregulated pro-inflammatory mediators and activated transcription factors, CEE downregulated the mRNA expression of cytokines including interleukin-6, interleukin-1β, and tumor necrosis factor-α, protein expression of cyclooxygenase-2 and inducible nitric oxide synthase, as well as activation of nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3). Hence, our findings reveal that the anti-inflammatory properties of CEE, involving the downregulation of the expression of pro-inflammatory mediators by inactivating NF-κB and STAT3 in DSS-induced colitis mice.

N-(3-Methozybenzyl)-(9Z,12Z,15Z)-octadecatrienamide from maca (Lepidium meyenii Walp.) ameliorates corticosterone-induced testicular toxicity in rats

2020 ◽  
Vol 11 (9) ◽  
pp. 7762-7774
Author(s):  
Zejun Yu ◽  
Hao Liu ◽  
Dong Li ◽  
Xuemin Chen ◽  
Mingzhang Ao ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Testicular Toxicity ◽  
Protective Effects ◽  
Lepidium Meyenii

This study investigated the protective effects of maca ethanol extract (EEM) and N-(3-methozybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (M 18:3) on corticosterone (CORT)-induced testicular toxicity.

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