scholarly journals Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model

2020 ◽  
Vol 128 ◽  
pp. 110120 ◽  
Author(s):  
Mohammad Reza Farahpour ◽  
Ehsan Pirkhezr ◽  
Ali Ashrafian ◽  
Ali Sonboli
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Essential Oil ◽  
Topical Administration ◽  
Salvia Officinalis ◽  
Infected Wound ◽  
Wound Model ◽  
And Staphylococcus Aureus

Chemical Composition and Antibacterial Activity of Essential Oils of Three Medicinal Plants from Algerian Semi-Arid Climatic Zone

2018 ◽  
Vol 16 (S1) ◽  
pp. S155-S163 ◽  
Author(s):  
S. Mehalaine ◽  
O. Belfadel ◽  
T. Menasria ◽  
A. Messaili
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Rosmarinus Officinalis ◽  
Salvia Officinalis ◽  
Thymus Algeriensis

The present study was carried out to determine, for the first time, the chemical composition and antibacterial activity of essential oils derived from the aerial parts of three aromatic plants Thymus algeriensis Boiss & Reut, Rosmarinus officinalis L., and Salvia officinalis L. growing under semiarid conditions. The essential oils were chemically analyzed and identified by gas chromatography (GC) and GC/ mass spectrometry (GC/MS) and their antimicrobial activity was individually evaluated against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using both agar disk diffusion and agar dilution methods. The major constituents of Thymus algeriensis essential oil were identified as camphor (13.62%), 1,8-cineol (6.00%), borneol (5.74%), viridiflorol (4.00%), and linalool (3.93%). For Rosmarinus officinalis essential oil, 48 compounds were characterized, of which the main constituents were camphor (17.09%), Z-β-ocimene (10.88%), isoborneol (9.68%), α-bisabolol (7.89%), and borneol (5.11%). While, Salvia officinalis essential oil was characterized by β-thujone (16.44%), followed by viridiflorol (10.93%), camphor (8.99%), 1,8-cineol (8.11%), trans-caryophyllene (5.85%), and α-humulene (4.69%) as the major components. Notably, results from antibacterial screening indicated that Thymus algeriensis and Salvia officinalis essential oils exhibited a strong inhibitory effect against both Escherichia coli and Staphylococcus aureus compared to Rosmarinus officinalis essential oil. Further, less activity was recorded against Pseudomonas aeruginosa for the three tested essential oils.

scholarly journals Antibacterial activity of lavender essential oil and linalool combined with gentamicin on selected bacterial strains

2019 ◽  
Vol 75 (05) ◽  
pp. 6279-2019
Author(s):  
MICHALINA ADASZYŃSKA-SKWIRZYŃSKA ◽  
DANUTA SZCZERBIŃSKA ◽  
SŁAWOMIR ZYCH
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Essential Oil ◽  
Inhibitory Concentration ◽  
Synergistic Interaction ◽  
Antibacterial Drug ◽  
Bacterial Strains ◽  
Staphyloccocus Aureus ◽  
And Staphylococcus Aureus

The aim of this study was to verify the existence of the synergistic antibacterial effect of lavender essential oil and linalool individually combined with the antibacterial drug gentamicin. We investigated in vitro the effectiveness of the combinations of gentamicin and lavender essential oil and of gentamicin and linalool against the following strains: Staphylococus aureus ATCC 25923, Staphylococus aureus MRSA and Pseudomonas aeruginosa ATCC 9027. In order to determine the sensitivity of these microorganisms, we determined the minimum inhibitory concentration (MIC – Minimal Inhibitory Concentration). The study of the interaction of gentamicin with lavender oil and linalool was evaluated by the checkerboard method. Synergistic interaction between lavender essential oil and gentamicin and between linalool and gentamicin was observed against Staphylococcus aureus ATCC 25923 and Staphylococcus aureus MRSA. In particular, a very strong synergistic interaction was observed against Staphyloccocus aureus MRSA (lavender essential oil FIC index = 0.14; linalool FIC index = 0.13). In contrast, combinations of gentamicin and lavender essential oil and of gentamicin and linalool were less effective against Pseudomonas aeruginosa growth.

scholarly journals Synergistic Interactions of Pseudomonas aeruginosa and Staphylococcus aureus in anIn VitroWound Model

2014 ◽  
Vol 82 (11) ◽  
pp. 4718-4728 ◽  
Author(s):  
Stephanie DeLeon ◽  
Allie Clinton ◽  
Haley Fowler ◽  
Jake Everett ◽  
Alexander R. Horswill ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Chronic Wounds ◽  
Wound Infections ◽  
Content Type ◽  
Synergistic Interactions ◽  
Wound Model ◽  
Common Causes ◽  
And Staphylococcus Aureus

ABSTRACTIn individuals with polymicrobial infections, microbes often display synergistic interactions that can enhance their colonization, virulence, or persistence. One of the most prevalent types of polymicrobial infection occurs in chronic wounds, wherePseudomonas aeruginosaandStaphylococcus aureusare the two most common causes. Although they are the most commonly associated microbial species in wound infections, very little is known about their interspecies relationship. Evidence suggests thatP. aeruginosa–S. aureuscoinfections are more virulent than monoculture infection with either species; however, difficulties in growing these two pathogens togetherin vitrohave hampered attempts to uncover the mechanisms involved. Here we describe a simple and clinically relevantin vitrowound model that supported concomitant growth ofP. aeruginosaandS. aureus. We observed that the ability ofP. aeruginosaandS. aureusto survive antibiotic treatment increased when they were grown together in planktonic cocultures and that antibiotic tolerance was further enhanced when they were grown together in the wound model. We attributed this enhanced tolerance to both the “host-derived” and “bacterium-derived” matrix components. Taken together, our data indicate thatP. aeruginosaandS. aureusmay benefit each other by coinfecting wounds and that the host-derived matrix may serve as important a role as the bacterium-derived matrix in protecting bacteria from some antibiotics.

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