F111. Multiple Pathways to Suicidal Behavior: Genetic and Neurocognitive Differences Between Suicide Attempters With High and Low Aggression-Impulsivity and Non-Attempters

2018 ◽  
Vol 83 (9) ◽  
pp. S280-S281
Author(s):  
Hanga Galfalvy ◽  
Jia Guo ◽  
John Keilp ◽  
Barbara Stanley ◽  
Maria Oquendo ◽  
...  
Keyword(s):  
Suicidal Behavior ◽  
Behavior Genetic ◽  
Suicide Attempters

Self-Report vs. Computerized Measures of Impulsivity as a Correlate of Suicidal Behavior

Crisis ◽  
2001 ◽  
Vol 22 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Netta Horesh
Keyword(s):  
Suicidal Behavior ◽  
Attention Deficit Disorder ◽  
Impulse Control ◽  
Performance Test ◽  
Adolescent Suicide ◽  
Continuous Performance Test ◽  
Self Report ◽  
Suicide Attempters ◽  
Computerized Measures ◽  
Adolescent Suicide Attempters

Objectives: To compare the use of a self-report form of impulsivity versus a computerized test of impulsivity in the assessment of suicidal adolescent psychiatric inpatients. Methods: Sixty consecutive admissions to an adolescent in patient unit were examined. The severity of suicidal behavior was measured with the Childhood Suicide Potential Scale (CSPS), and impulse control was measured with the self report Plutchik Impulse Control Scale (ICS) and with the Test of Variables of Attention (TOVA), a continuous performance test (CPT). The TOVA is used to diagnose adolescents with attention deficit disorder. Results: There was a significant but low correlation between the two measures of impulsivity. Only the TOVA commission and omission errors differentiated between adolescent suicide attempters and nonattempters. Conclusions: Computerized measures of impulsivity may be a useful way to measure impulsivity in adolescent suicide attempters. Impulsivity appears to play a small role only in nondepressed suicidal adolescents, especially boys.

Validity of Proxy-Based Reports of Impulsivity and Aggression in Chinese Research on Suicidal Behavior

Crisis ◽  
2010 ◽  
Vol 31 (3) ◽  
pp. 137-142 ◽  
Author(s):  
Jing An ◽  
Michael R. Phillips ◽  
Kenneth R. Conner
Keyword(s):  
Risk Factors ◽  
Suicidal Behavior ◽  
Rural China ◽  
Suicide Attempters ◽  
Barratt Impulsiveness Scale ◽  
Single Location ◽  
Aggression Questionnaire ◽  
Community Controls

Background: In studies about the risk factors for suicidal behavior, the assessment of impulsiveness and aggression often depend on information from proxy informants. Aims: To assess the validity of proxy informants’ reports on impulsiveness and aggression in China. Methods: Modified Chinese versions of the Barratt Impulsiveness Scale (BIS-CV) and the Buss-Perry Aggression Questionnaire (AQ-CV) were administered to 131 suicide attempters treated at a hospital in rural China, to coresident relatives about the attempters, to 131 matched community controls, and to coresident relatives about the controls. Results: BIS-CV and AQ-CV total scores and subscale scores were all significantly higher for suicide attempters than for matched controls. Proxy informants considered subjects slightly more impulsive and aggressive than the subjects reported themselves. Subject-proxy concordance for total BIS-CV and AQ-CV scores were excellent for both attempters and controls (ICCs = 0.76–0.83). Concordance for the three BIS-CV subscales was 0.74–0.81 for attempters and 0.74–0.83 for controls. Concordance for the five AQ-CV subscales was 0.66–0.85 for attempters and 0.56–0.82 for controls. Limitations: Results are based on respondents from a single location in rural China. Conclusions: The results support the validity of the BIS-CV and AQ-CV and of research on suicidal behavior in China that uses proxy-based reports of impulsiveness and aggression.

scholarly journals Chromosome 22 Deletions and Suicidal Behavior in Schizophrenia

2021 ◽  
pp. 1-8
Author(s):  
Ali Bani-Fatemi ◽  
Christopher Adanty ◽  
Nasia Dai ◽  
Ariel Graff ◽  
Philip Gerretsen ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Suicidal Behavior ◽  
Copy Number ◽  
Rating Scale ◽  
Copy Number Variant ◽  
Chromosome 22 ◽  
Suicide Attempters ◽  
Severity Rating ◽  
Neuropsychiatric Diseases ◽  
Significant Difference

Background: Studies have shown that the overall copy number variant (CNV) load is associated with schizophrenia. Schizophrenia is a mental disorder that is frequently associated with suicidal behavior. Methods: We recruited 263 patients with schizophrenia from the Centre for Addiction and Mental Health. The Columbia Suicide Severity Rating Scale was used to assess the presence of lifetime suicide attempt. Genotyping was completed using the Illumina Omni 2.5 chip. We tested the association between deletion events on chromosome 22 with suicide attempt in our schizophrenia sample. Results: There was no significant difference between suicide attempters and non-attempters considering the presence/absence of deletion events on chromosome 22. Conclusion: Although our results did not show a significant association between deletions on chromosome 22 and suicide attempt in schizophrenia, CNV studies may reveal important, novel insights and open further investigation for the treatment of neuropsychiatric diseases.

Aggressiveness, not impulsiveness or hostility, distinguishes suicide attempters with major depression

2006 ◽  
Vol 36 (12) ◽  
pp. 1779-1788 ◽  
Author(s):  
JOHN G. KEILP ◽  
MARIANNE GORLYN ◽  
MARIA A. OQUENDO ◽  
BETH BRODSKY ◽  
STEVEN P. ELLIS ◽  
...  
Keyword(s):  
Major Depression ◽  
Suicidal Behavior ◽  
Borderline Personality ◽  
Biological Research ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Large Numbers ◽  
History Of ◽  
Patient Subgroups ◽  
The Ideal

Background. Impulsiveness, hostility and aggressiveness are traits associated with suicidal behavior, but also with borderline personality disorder (BPD). The presence of large numbers of BPD subjects in past attempter samples may distort the relative importance of each of these traits to predicting suicidal behavior, and lead to prospective, biological and genetic models that systematically misclassify certain subpopulations of suicidal individuals.Method. Two hundred and seventy-five subjects with major depressive disorder (MDD), including 87 with co-morbid BPD (69 past suicide attempters, 18 non-attempters) and 188 without BPD (76 attempters, 112 non-attempters) completed standard impulsiveness, hostility and aggressiveness ratings. Differences between past suicide attempters and non-attempters were examined with the sample stratified by BPD status.Results. As expected, BPD subjects scored significantly higher than non-BPD subjects on all three trait measures. Stratifying by BPD status, however, eliminated attempter/non-attempter differences in impulsiveness and hostility in both patient subgroups. Past suicide attempters in each of the two subgroups of patients were only distinguished by higher levels of aggressiveness.Conclusions. Once BPD is accounted for, a history of aggressive behavior appears to be the distinguishing trait characteristic of suicide attempters with major depression, rather than global personality dimensions such as impulsiveness or hostility. Aggressiveness, and not these related traits, may be the ideal target for behavioral, genetic and biological research on suicidal behavior, as well as for the clinical assessment of suicide risk.

Relationships between attempted suicide, temperamental vulnerability, and violent criminality in a Swedish forensic psychiatric population

2001 ◽  
Vol 16 (7) ◽  
pp. 386-394 ◽  
Author(s):  
E. Gunilla Stålenheim
Keyword(s):  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Personality Profiles ◽  
Suicide Attempters ◽  
Criminal Violence ◽  
Platelet Mao ◽  
Significant Difference ◽  
Clinical Diagnoses ◽  
Mao Activity ◽  
Forensic Psychiatric

SummaryThe relationship between suicide attempts and different vulnerability factors was investigated in 61 male subjects during forensic psychiatric examination. Personality traits and psychopathy were determined by means of the Karolinska Scales of Personality (KSP) and the Psychopathy Checklist-Revised (PCL-R). Clinical diagnoses were determined by the use of Structured Clinical Interview for DSM-III-R (SCID). Platelet monoamine oxidase (MAO) activity was investigated in 58 subjects.Suicide attempters had extremely low socialization and high impulsive aggression. This was independent of a history of repeatedly criminal violence or not. They had higher PCL-R scores and lower levels of platelet MAO activity than non-attempters. No relationship was found between suicide attempts and repeated violent criminality. However, among the subjects with repeated criminal violence there was a highly significant difference between suicide attempters and non-attempters, indicating different personality profiles in violent offenders with and without suicidal behavior. Suicidal behavior was significantly associated with borderline personality disorder, but not with any other single DSM-III-R disorder. The results show a far more severe personality disturbance in suicide attempters than in other violent patients in this type of population. Suicidal behavior should therefore be evaluated and treated per se.

scholarly journals Interaction of Psychological and Neurobiological Risk Factors in the Background of Suicidal Behavior

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
A. Szkaliczki ◽  
P.Z. Álmos ◽  
B. Andó ◽  
E. Krivek ◽  
J. Kálmán ◽  
...  
Keyword(s):  
Risk Factors ◽  
Suicidal Behavior ◽  
Iowa Gambling Task ◽  
Study Data ◽  
Health State ◽  
Novelty Seeking ◽  
Social Deviance ◽  
Suicide Attempters ◽  
Current Medication ◽  
Character Inventory

Aims:Many studies investigated social, psychological, existential and environmental risk factors in the background of suicidal behavior, while recent researches put emphasis on the neurobiological basis by revealing impairments in decision-making related to the ventromedial prefrontal cortex. In this ongoing study we aimed to integrate these approaches with examining the correlating factors of personality character traits, impulsivity and the function of ventromedial cortex.Methods:30 suicide attempters and 28 controls participated in our study. Data regarding the act of suicide, previous attempts, personal and family history, current medication and general health state were recorded. All participants received Temperament and Character Inventory (TCI) and Barratt Impulsivity Scale (BIS) and they were asked to perform the computerized version of Iowa Gambling Task (IGT).Results:Suicide attempters scored significantly higher on BIS. They achieved significantly higher harm avoidance and transcendence scores and lower self-directedness, social deviance and cooperation scores on TCI (p< 0.05). Suicide attempters selected less advantageous desks on both reward and punishment sensitive tasks of IGT (p< 0.05). Significant correlation was found between novelty-seeking personality trait and punishment sensitivity (p< 0.05).Conclusion:Our study supports the previous findings regarding the impairment of ventromedial cortex in the background of suicidal behavior. Furthermore, we demonstrated relation between this alteration and specific personality traits of suicide patients. This approach may shed light on the interaction of psychological and neurobiological risk factors.

scholarly journals Bipolar disorder first episode and suicidal behavior: are there differences according to type of suicide attempt?

2009 ◽  
Vol 31 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Fernando Silva Neves ◽  
Leandro Fernandes Malloy-Diniz ◽  
Izabela Guimarães Barbosa ◽  
Paulo Marcos Brasil ◽  
Humberto Corrêa
Keyword(s):  
Bipolar Disorder ◽  
Logistic Regression ◽  
Suicidal Behavior ◽  
Suicide Attempts ◽  
First Episode ◽  
Mean Square ◽  
Suicide Attempters ◽  
Lifetime History ◽  
Bipolar Ii ◽  
History Of

OBJECTIVE: The objective of this study was to test the hypothesis that the polarity of the first mood episode may be a marker for suicidal behavior, particularly the violent subtype. METHOD: One hundred and sixty-eight patients diagnosed with bipolar disorder (DSM-IV) were grouped according to type of first episode: depression or manic/hypomanic. Groups were compared for demographic and clinical variables. We performed logistic regression in order to test the association between first episode polarity and suicidal behavior. RESULTS: We found that depressed patients have a lifetime history of more suicide attempts. However, univariate analysis of number of suicide attempts showed that the best model fits the bipolar II subtype (mean square = 15.022; p = 0.010) and lifetime history of psychotic episodes (mean square = 17.359; p = 0.021). Subgrouping the suicide attempts by subtype (violent or non-violent) revealed that manic/hypomanic patients had a greater tendency toward attempting violent suicide (21.2 vs. 14.7%, X² = 7.028, p = 0.03). Multiple logistic regression analysis confirmed this result. CONCLUSION: Depressed patients had more suicide attempts over time, which could be explained by the higher prevalence of bipolar II subtype in this group, whereas manic/hypomanic patients had a lifelong history of more frequent violent suicide attempts, not explained by any of the variables studied. Our results support the evidence that non-violent suicide attempters and violent suicide attempters tend to belong to different phenotypic groups.

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