A critical perspective on the synaptic pruning hypothesis of schizophrenia pathogenesis

Author(s):  
Matthew B. Johnson ◽  
Steven E. Hyman
2012 ◽  
Vol 3 (1) ◽  
pp. 425-426
Author(s):  
Dr N. M. Sali Dr N. M. Sali ◽  

2019 ◽  
Vol 6 (1) ◽  
pp. 25-39
Author(s):  
Adriana Backx Noronha Viana ◽  
Luísa Cagica Carvalho ◽  
Inna Sousa Paiva

Background: Wine tourism is one of the tourism components adopted as part of Portugal’s strategy due to its eminence as a wine producer. Such strategy has received great prominence in recent years and aims to promote regional development from an economic, social, cultural and environmental perspective. The aim of this study was to understand the entrepreneur profile in this sector. Methods: The study uses a qualitative, case study methodology with data analysis and triangulation. In this study, a literature review of scientific studies was carried out on the scientific knowledge in the area of study from a critical perspective and an interview was conducted where qualitative data were collected. Results and Discussion: The entrepreneurs have shown the following characteristics: initiative, innovation capability, optimism, creativity, creative energy, tenacity, selfconfidence, capability for long term involvement with the project, and learning capacity. Conclusion: The study shows that most entrepreneurs state that they have established partnerships with other companies, particularly with restaurants, catering businesses, hotel units, tourism companies and companies that organize tours. This is one of the factors of economic importance recognized by another study which enables increased prominence of the company and widens the value of wine tourism.


Author(s):  
Nida Alahmad

This chapter argues that, while we can conceive of a ‘global’ or a ‘regional’ governance structure, a ‘critical regional perspective’ is not possible for three reasons. First, there is a problem of governance as a technology of ordering the world that requires the production of abstracted forms of knowledge; second, the problem of determining what a critical ‘regional’ perspective on global governance might be; and third, a critical perspective that would account for the daily lives of people cannot be produced by regional institutions, which are rarely representative of popular democratic movements. In the Middle East, the Arab League has historically been weak, reflecting turbulent regional power relations. As such, it is difficult to identify a regional perspective based on the League’s governance practices. If a regional political counter-perspective to global governance is not possible (as in the Middle East), one cannot speak of a cultural (counter) perspective on governance.


2021 ◽  
Vol 7 (2) ◽  
pp. 205630512110101
Author(s):  
Zoe Hurley

Social media intersects across physical spaces, digital infrastructures, and social subjectivities in terms of what is being called the “postdigital,” in an increasingly merging offline/online world. But what precisely does it mean to be “postdigital” if you are an Arab woman or social actor in the Global South? How does access to social networking sites, while increasing visibilities, also provide potential for increased agency? This study is concerned with the extent to which Arab women’s self-presentation practices on Instagram could be considered as empowering, or otherwise, within the postdigital condition. First, the study takes Instagram as a case to develop a theoretical framework for considering social media as a tertiary artifact, involving material, routine-symbolic, and conceptual affordances. Second, it applies the artifact framework to explore a corpus of self-presentations by five Arab women influencers. Feminist postdigital theorizing offers unique contributions to problematizing normative, ethnocentric, and neoliberal conceptions of Arab women’s empowerment. The application of the novel framework leads to an interpretative discussion of Arab women’s influencing practices across merging offline/online and transnational boundaries. Overall, the critical perspective begins to reimagine Arab women’s empowerment, not simply as individualized or material processes, but as agencies that are interwoven within the commercialized and conceptual dynamics of visual social media.


2021 ◽  
pp. 204382062110174
Author(s):  
Elena Burgos Martinez

This commentary begins by outlining current debates on the notion of the Anthropocene from a critical perspective. Subsequently, it will discuss how Pugh and Chandler (2021) directly address such a problematic and how their work contributes to pluralising contemporary academic debates on the Anthropocene. Their previous academic engagements are no stranger to questions of epistemic discrimination in the broad fields of geography, geopolitics, island studies, and social research, and, more concretely, mainstreamed anthropological thinking. This commentary will therefore focus on their call for storiation and its relevance for contemporary debates seeking more ethical, localised, fluid, and coherent approaches to environmental degradation, environmental history, island identity, geopolitics of climate change, and indigeneity. From all the shapes storiation can take, this commentary focuses on indigenous storiation as embodiment.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xin Ding ◽  
Jin Wang ◽  
Miaoxin Huang ◽  
Zhangpeng Chen ◽  
Jing Liu ◽  
...  

AbstractMicroglia play a key role in regulating synaptic remodeling in the central nervous system. Activation of classical complement pathway promotes microglia-mediated synaptic pruning during development and disease. CD47 protects synapses from excessive pruning during development, implicating microglial SIRPα, a CD47 receptor, in synaptic remodeling. However, the role of microglial SIRPα in synaptic pruning in disease remains unclear. Here, using conditional knock-out mice, we show that microglia-specific deletion of SIRPα results in decreased synaptic density. In human tissue, we observe that microglial SIRPα expression declines alongside the progression of Alzheimer’s disease. To investigate the role of SIRPα in neurodegeneration, we modulate the expression of microglial SIRPα in mouse models of Alzheimer’s disease. Loss of microglial SIRPα results in increased synaptic loss mediated by microglia engulfment and enhanced cognitive impairment. Together, these results suggest that microglial SIRPα regulates synaptic pruning in neurodegeneration.


2021 ◽  
pp. 1-7
Author(s):  
Luana da Silva Chagas ◽  
Poliana Capucho Sandre ◽  
Patricia Coelho de Velasco ◽  
Henrique Marcondes ◽  
Natalia Cristina Aparecida Ribeiro e Ribeiro ◽  
...  

COVID-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) betacoronavirus, affects children in a different way than it does in adults, with milder symptoms. However, several cases of neurological symptoms with neuroinflammatory syndromes, such as the multisystem inflammatory syndrome (MIS-C), following mild cases, have been reported. As with other viral infections, such as rubella, influenza, and cytomegalovirus, SARS-CoV-2 induces a surge of proinflammatory cytokines that affect microglial function, which can be harmful to brain development. Along with the viral induction of neuroinflammation, other noninfectious conditions may interact to produce additional inflammation, such as the nutritional imbalance of fatty acids and polyunsaturated fatty acids and alcohol consumption during pregnancy. Additionally, transient thyrotoxicosis induced by SARS-CoV-2 with secondary autoimmune hypothyroidism has been reported, which could go undetected during pregnancy. Together, those factors may pose additional risk factors for SARS-CoV-2 infection impacting mechanisms of neural development such as synaptic pruning and neural circuitry formation. The present review discusses those conditions in the perspective of the understanding of risk factors that should be considered and the possible emergence of neurodevelopmental disorders in COVID-19-infected children.


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