Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception

The avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regulate nutritional balance. Until recently, research on the central regulation of food intake primarily focused on neuronal signaling, with little attention paid to the role of glial cells. Over the last few decades, our understanding of glial cells has changed dramatically. These cells are increasingly regarded as important neuronal partners, contributing not just to cerebral homeostasis, but also to cerebral signaling. Our understanding of the central regulation of energy balance is part of this (r)evolution. Evidence is accumulating that glial cells play a dynamic role in the modulation of energy balance. In the present review, we summarize recent data indicating that the multifaceted glial compartment of the brainstem dorsal vagal complex (DVC) should be considered in research aimed at identifying feeding-related processes operating at this level.

Potential of dietary supplementation with berries to enhance immunity in humans

One of the most prominent concerns that has arisen from global events such as the Coronavirus Disease 2019 (COVID-19) pandemic is how the immune system might be enhanced to provide greater protection against malignant conditions and diseases. Dietary modification is one of the major fields of research, with special focus on how diet interacts with immunity through impacts on factors such as the gut microbiome, inflammation, and nutritional imbalance. This review focuses on current research regarding the use of bioactives derived from berries as a dietary supplement to improve immunity, with discussions of relevant clinical studies. Major bioactive, metabolic compounds of focus- flavonoids, anthocyanins, alkaloids, dietary fiber, and stilbenes- have demonstrated biochemical merits in modulating immunity. In addition, blueberries, goji berries, black raspberries, and cranberries, which have been extensively researched and recently gained interest for their effects on the immune system in animal and cell models, may also hold promise in providing similar benefits to humans, though the precise immunological effects have yet to be clearly determined. Overall, the field of berry research as it relates to diet and immunity shows potential, but more clinical studies will be necessary for a full understanding of the mechanisms of berry immunomodulation.

SPECIALIZED BAKERY PRODUCTS FOR THE CORRECTION OF NUTRITIONAL IMBALANCE IN SCHOOL-AGE CHILDREN

The article considers aspects of the development of technology for the production of bakery products for the nutrition of school-age children with a low content of salt (sodium) and sugar, contributing to the correction of nutritional imbalance, prevention and reduction of risk factors for non-communicable diseases. The analysis of retrospective data on the actual nutrition and nutrient deficiency of school-age children of the Republic of Belarus is carried out, the ingredient compositions and individual indicators of the nutritional value of the developed specialized bakery products for the nutrition of school-age children are substantiated. The raw materials, the use of which is possible in the production of specialized bakery products for the nutrition of school-age children, have been studied. The influence of various ingredients (salt, sugar, mineral complexes, inulin) in different dosages on the rheological characteristics, gas-forming and gas-retaining properties of the dough was studied. Based on the analysis of scientific, technical and regulatory literature, the ingredient composition and individual indicators of the nutritional value of the developed specialized bakery products with a low content of salt and sugar are justified. Technologies for the production of bakery products specialized for the nutrition of school-age children (drying, straws) have been developed. The parameters of conducting the technological process in production conditions that provide the appropriate organoleptic indicators of bakery products are established.

Salinity tolerance of tomato fertigated with different K+/Ca2+ proportions in protected environment

ABSTRACT Adequate potassium and calcium nutrition is a strategy to reduce salt stress on tomatoes, as it reduces nutritional imbalance in plants. With the objective of evaluating tomato production using irrigation with saline waters and fertigation with different potassium-calcium proportions, an experiment was carried out in a protected environment in Mossoró, RN, Brazil. The experimental design used was randomized blocks, in a 5 x 4 factorial scheme, with four replicates. The treatments consisted of the combination of four electrical conductivity of nutrient solution (ECns) (1.75; 3.25; 4.75; and 6.25 dS m-1) combined with five ionic proportions (m/m) of potassium and calcium (F1 = 2.43:1; F2 = 2.03:1; F3 = 1.62:1; F4 = 1.30:1 and F5 = 1.08:1). The response variables were: number of fruits, mean fruit weight, fruit production per plant and relative yield. It was possible to identify satisfactory results of production when higher salinity was used. Fertigation with low K+/Ca2+ proportions intensifies the effect of salinity on tomato crop.

Taxonomical, Phytochemical, Traditional Explanation, Nutritional Values, and Biological Activities of Certain Edible Medicinal Plants of Tripura, India

Edible plants are used as valuable sources of food and medicine to prevent nutritional imbalance, illness, and maintenance of human health. This review covers botanical descriptions, phytochemicals studies, traditional comprehensions, dietary values, and biological activities of ten vegetable plants and eight fruit plants of Tripura, India. The book “The Flora of Tripura State” helps to choose the plant species of Tripura, India and PubMed, NCBI, Google scholar databases have been used to describe the plant species briefly. Literature reveals that all the selected edible plants contain bio-active constituents (alkaloids, phenols, flavonoids, tannins, terpenoids, glycosides, etc.) and give dynamic biological activities. All the plants have a high nutritional value. This review believes it will provide significant advances in the prevention of malnutrition and chronic diseases.

Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice

Chronic dietary protein-restriction can create essential amino acid deficiencies and induce metabolic adaptation through the hepatic FGF21 pathway which serves to maintain host fitness during prolonged states of nutritional imbalance. Similarly, the gut microbiome undergoes metabolic adaptations when dietary nutrients are added or withdrawn. Here we confirm previous reports that dietary protein-restriction triggers the hepatic FGF21 adaptive metabolic pathway and further demonstrate that this response is mediated by the gut microbiome and can be tuned through dietary supplementation of fibers that alter the gut microbiome. In the absence of a gut microbiome, we discover that FGF21 is de-sensitized to the effect of protein-restriction. These data suggest that host-intrinsic adaptive pathways to chronic dietary protein-restriction, such as the hepatic FGF21 pathway, may in-fact be responding first to adaptive metabolic changes in the gut microbiome.

LODO DE CURTUME EM SUBSTRATO COMERCIAL PARA PRODUÇÃO DE MUDAS DE MAMÃO CV. GOLDEN THB

LODO DE CURTUME EM SUBSTRATO COMERCIAL PARA PRODUÇÃO DE MUDAS DE MAMÃO CV. GOLDEN THB OTTO HERBERT SCHUHMACHER DIETRICH1, MÁRCIA ADRIANA CARVALHO DOS SANTOS2, VINICIUS RODRIGUES FERREIRA3, SÁVIO DA SILVA BERILLI4, ANA PAULA CANDIDO GABRIEL BERILLI5 1 Instituto Federal do Espírito Santo, Campus Barra de São Francisco, Av. Herculano Fernandes de Jesus, 111, Irmãos Fernandes, CEP: 29800-000, Barra de São Francisco-ES, Brasil. [email protected] 2Embrapa Semiárido, Rodovia BR-428, Km 152, Zona Rural, CEP: 56302-970, Petrolina-PE, Brasil. [email protected] 3Programa de Pós-graduação em Agroecologia, Instituto Federal do Espírito Santo, Campus de Alegre, Rodovia BR-482, Km 40, Rive, CEP: 29500-000, Alegre-ES, Brasil. [email protected] 4Programa de Pós-graduação em Agroecologia, Instituto Federal do Espírito Santo, Campus de Alegre, Rodovia BR-482, Km 40, Rive, CEP: 29500-000, Alegre-ES, Brasil. [email protected] 5Programa de Pós-graduação em Agroecologia, Instituto Federal do Espírito Santo, Campus de Alegre, Rodovia BR-482, Km 40, Rive, CEP: 29500-000, Alegre-ES, Brasil. [email protected] RESUMO: O aproveitamento de resíduos para produção de mudas pode ser uma solução acessível em áreas produtoras de mamão, como alternativa ao uso de substratos comerciais. Assim, este estudo avaliou o efeito do lodo de curtume na produção de mudas de mamão cv. Golden THB. Foram testadas as proporções 0, 15, 30, 45 e 60% de lodo de curtume em mistura com substrato comercial, avaliando as características de emergência, biométricas, gravimétricas e de qualidade de mudas. Os resultados foram submetidos ao teste F e Dunnett (p< 0,05). Os substratos com lodo tiveram desempenho similar ao comercial em todas as características de emergência, mas inferiores para altura da muda, área foliar, matéria fresca e seca da parte aérea e raiz e IQD. Para o número de folhas e diâmetro do caule, apenas a proporção de 15% foi semelhante ao substrato comercial. A análise de regressão apontou que o aumento das proporções de lodo de curtume reduziu gradualmente as médias das variáveis analisadas, exceto para percentagem de emergência. Isso pode estar relacionado a salinidade do lodo, além de desequilíbrios nutricionais. Portanto, a mistura de lodo de curtume ao substrato comercial limitou o desenvolvimento e a qualidade das mudas de mamoeiro cv. Golden THB. Palavras-chaves: propagação, resíduo alternativo, sustentabilidade, redução de custos, Carica papaya. TANNERY SLUDGE IN COMMERCIAL SUBSTRATE FOR THE PRODUCTION OF PAPAYA SEEDLINGS CV. GOLDEN THB ABSTRACT: The use of residues for the production of papaya seedlings can mention an accessible solution to the producing areas. Therefore, the objective was to evaluate the influence of portions of 0 to 60% of tannery sludge in a mixture with a commercial substrate, traditionally used in papaya propagation, to evaluate the emergence, biometric, gravimetric and quality characteristics of papaya seedlings. cv. Golden THB. The emergence characteristics had a similar performance between the proposed and commercial substrates. Overall, there were significant differences between treatments with more than 15% tannery sludge and the commercial substrate. Except for the percentage of emergence, significant results were found for regression, with the answer being the indication that gradually with the increase in the portion of the tannery sludge to the commercial substrate, there was a reduction in the characteristics analyzed. Possibly, the effects of high salinity provided this response pattern, in addition to the nutritional imbalance as a result. Despite the good results of the emergence characteristics, in general, the mixture of tannery sludge to the commercial substrate limited the development and quality of papaya seedlings cv. Golden THB, for use only in proportions up to 15% of sludge. Keywords: propagation, alternative waste, sustainability, cost reduction, Carica papaya.

Clinical and Nutritional Implications of Kidney Disease and COVID-19

By the end of 2019, emerged a cluster of pneumonia caused by a novel SARS-CoV-2 virus. The disease, subsequently named COVID-19, has a wide range of signs and symptoms, including fever, respiratory and gastrointestinal manifestations, and kidney disease that can evolve to a nutritional imbalance through direct and indirect mechanisms. Moreover, the prognosis of COVID-19 could worsen in high-risk populations like kidney disease patients, given their depressed immunity and impaired nutritional state. Therefore, previous reports suggest prioritizing a nutritional approach in these patients, adjusting for individual dietary needs. Thus, we aim to explore the current knowledge about the clinical and nutritional implications of patients with COVID-19 who develop acute or chronic kidney disease, highlighting proposed dietary recommendations in this group of patients.

The role of nutrtion in children with celiac disease

Celiac disease, a permanent, irreversible but treatable disease is an autoimmune disease triggered by gluten ingestion in genetically predisposed individuals, also known as celiac sprue and gluten sensitive enteropathy. Recent findingsIntestinal inflammation and villous atrophy in small intestines by permanent intolerance to gluten in celiac disesea leads to seveare malabsorption. About 20%-38% patients were basically nutritionally imbalance secondary malabsorption due to mucosal damage. Nutrition plays a very important role in the management of celiac disease. Gluten free diet must be balanced to cover nutrient requirements to prevent deficiencies and ensure children’s health, growth and development.Conclusion Gluten-free diet is the only accepted and available treatment in CD. It was a life-long treatment, if not carried out with attention, it may lead to nutritional imbalance which can affect children’s growth and development