A reaction of 2-(bromomethyl)thioxanthone with sodium methanethiolate with sodium methanethiolate gave 2-(methylthiomethyl)thioxanthone (II) which was transformed by treatment with 3-dimethylaminopropylmagnesium chloride to the tertiary alcohol IV. Its dehydration by heating with dilute sulfuric acid afforded the title compound I. An attempt at preparing the analogous 2-(methoxymethyl) derivative proceeded similarly but failed in the stage of the acid-catalyzed dehydration of the tertiary alcohol V. Acids VIII-XII and the nitrile XIII were prepared as potential intermediates. Compound I has properties of a tranquilizer with a weak cataleptic activity.
The acid catalyzed condensation of levulinic acid with paraformaldehyde at 80 °C gives 2,9,11,14-tetraoxadispiro[4.1.5.3]pentadecane-3,6-dione, in which the structure was confirmed by X-ray crystallography.
Enhanced Succinic Acid Production from Sake Lees Hydrolysate by Dilute Sulfuric Acid Pretreatment and Biotin Supplementation