Carbonic anhydrase regulation and CO2 sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog

2013 ◽  
Vol 21 (6) ◽  
pp. 1549-1554 ◽  
Author(s):  
Fabien Cottier ◽  
Worraanong Leewattanapasuk ◽  
Laura R. Kemp ◽  
Mariana Murphy ◽  
Claudiu T. Supuran ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Fungal Pathogen ◽  
Candida Glabrata

scholarly journals Jjj1 Is a Negative Regulator of Pdr1-Mediated Fluconazole Resistance in Candida glabrata

mSphere ◽  
2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Sarah G. Whaley ◽  
Kelly E. Caudle ◽  
Lucia Simonicova ◽  
Qing Zhang ◽  
W. Scott Moye-Rowley ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Antifungal Agents ◽  
Common Species ◽  
Negative Regulator ◽  
Gene Encoding ◽  
Fluconazole Resistance ◽  
Mechanism Of Resistance ◽  
Primary Mechanism ◽  
Activating Mutation

Candida glabrata is the second most common species of Candida recovered from patients with invasive candidiasis. The increasing number of infections due to C. glabrata, combined with its high rates of resistance to the commonly used, well-tolerated azole class of antifungal agents, has limited the use of this antifungal class. This has led to the preferential use of echinocandins as empirical treatment for serious Candida infections. The primary mechanism of resistance found in clinical isolates is the presence of an activating mutation in the gene encoding the transcription factor Pdr1 that results in upregulation of one or more of the efflux pumps Cdr1, Pdh1, and Snq2. By developing a better understanding of this mechanism of resistance to the azoles, it will be possible to develop strategies for reclaiming the utility of the azole antifungals against this important fungal pathogen.

Carbonic anhydrase inhibitors: Inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides

2013 ◽  
Vol 23 (9) ◽  
pp. 2647-2652 ◽  
Author(s):  
Daniela Vullo ◽  
Worraanong Leewattanapasuk ◽  
Fritz A. Mühlschlegel ◽  
Antonio Mastrolorenzo ◽  
Clemente Capasso ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Candida Glabrata ◽  
Pathogenic Yeast ◽  
Carbonic Anhydrase Inhibitors

scholarly journals Opportunistic fungal pathogen Candida glabrata circulates between humans and yellow-legged gulls

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohammed Hashim Al-Yasiri ◽  
Anne-Cécile Normand ◽  
Coralie L’Ollivier ◽  
Laurence Lachaud ◽  
Nathalie Bourgeois ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Opportunistic Fungal Pathogen

scholarly journals Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells

mBio ◽  
2021 ◽  
Author(s):  
Rocio Garcia-Rubio ◽  
Cristina Jimenez-Ortigosa ◽  
Lucius DeGregorio ◽  
Christopher Quinteros ◽  
Erika Shor ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Clinical Failure ◽  
First Line ◽  
Content Type ◽  
First Line Therapy ◽  
Line Therapy ◽  
Resistant Strains ◽  
Opportunistic Fungal Pathogen

Echinocandin drugs are a first-line therapy to treat invasive candidiasis, which is a major source of morbidity and mortality worldwide. The opportunistic fungal pathogen Candida glabrata is a prominent bloodstream fungal pathogen, and it is notable for rapidly developing echinocandin-resistant strains associated with clinical failure.

Understand the genomic diversity and evolution of fungal pathogen Candida glabrata by genome-wide analysis of genetic variations

Methods ◽  
2020 ◽  
Vol 176 ◽  
pp. 82-90 ◽  
Author(s):  
Xiaoxian Guo ◽  
Ruoyu Zhang ◽  
Yudong Li ◽  
Zhe Wang ◽  
Olena P. Ishchuk ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Genetic Variations ◽  
Genomic Diversity ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata

2011 ◽  
Vol 4 (1) ◽  
pp. 169-186 ◽  
Author(s):  
Michael Tscherner ◽  
Tobias Schwarzmüller ◽  
Karl Kuchler
Keyword(s):  
Drug Resistance ◽  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Antifungal Drug ◽  
Antifungal Drug Resistance ◽  
Human Fungal Pathogen

Candida glabrata: Multidrug Resistance and Increased Virulence in a Major Opportunistic Fungal Pathogen

2012 ◽  
Vol 6 (3) ◽  
pp. 154-164 ◽  
Author(s):  
Michael A. Pfaller ◽  
Mariana Castanheira ◽  
Shawn R. Lockhart ◽  
Ronald N. Jones
Keyword(s):  
Multidrug Resistance ◽  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Opportunistic Fungal Pathogen

scholarly journals High Resistance to Oxidative Stress in the Fungal Pathogen Candida glabrata Is Mediated by a Single Catalase, Cta1p, and Is Controlled by the Transcription Factors Yap1p, Skn7p, Msn2p, and Msn4p

2008 ◽  
Vol 7 (5) ◽  
pp. 814-825 ◽  
Author(s):  
Mayra Cuéllar-Cruz ◽  
Marcela Briones-Martin-del-Campo ◽  
Israel Cañas-Villamar ◽  
Javier Montalvo-Arredondo ◽  
Lina Riego-Ruiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Candida Albicans ◽  
Transcription Factors ◽  
Adaptive Response ◽  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Systemic Infection ◽  
Oxidative Stress Response

ABSTRACT We characterized the oxidative stress response of Candida glabrata to better understand the virulence of this fungal pathogen. C. glabrata could withstand higher concentrations of H2O2 than Saccharomyces cerevisiae and even Candida albicans. Stationary-phase cells were extremely resistant to oxidative stress, and this resistance was dependent on the concerted roles of stress-related transcription factors Yap1p, Skn7p, and Msn4p. We showed that growing cells of C. glabrata were able to adapt to high levels of H2O2 and that this adaptive response was dependent on Yap1p and Skn7p and partially on the general stress transcription factors Msn2p and Msn4p. C. glabrata has a single catalase gene, CTA1, which was absolutely required for resistance to H2O2 in vitro. However, in a mouse model of systemic infection, a strain lacking CTA1 showed no effect on virulence.

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